Functional heartburn in Iranian patients with non-erosive gastroesophageal reflux disease
- PDF |
- DOI: https://doi.org/10.15562/bmj.v7i1.811 |
- Published: 2018-04-15
Open Access & Peer Reviewed Multidisciplinary
Journal of Medical Sciences
Journal of Medical Sciences
Abstract
Aim: Esophageal multi channel intraluminal impedance-PH (MII-PH) monitoring is a new technique used for detecting the flow of fluids and gas through the esophagus, using the differences in electrical impedance between the mucosal surface, fluids, and gas that surround the catheter. The aim of this study was to determine the frequency of functional heartburn in Iranian patients with non-erosive gastroesophageal reflux disease (NERD).
Methods: In this study, 940 patients aged 11-84 years, with the chief complaint of heartburn were selected. The MII-PH monitoring was done in 215 of the patients who did not have esophageal injuries (NERD).
Results: Of the participants who filled the questionnaire, 29.4% experienced heartburn at least once a week, 24.1% had it twice daily, and 21.3% had it after each meal. The mean age of the patients with heartburn was 36.97 ± 10.8 (Range: 21- 57) years. Of the patients, 51.2% were female. MII-PH monitoring was done in 215 participants, with non-erosive esophagitis.
Esophageal acid exposure of time (EAET) was negative in 42.8% and positive in 57.2% of the NERD patients. Of the patients, 39.1% and 18.1% had functional heartburn (FH) and hypersensitive esophagus (HE), respectively
Conclusion: Functional heartburn and non-erosive gastroesophageal reflux disease are prevalent in the Iranian population. Esophageal multi channel intraluminal impedance-PH (MII-PH) monitoring is essential for discriminating functional heartburn from other types of non-erosive gastroesophageal reflux diseases.
References
- Beer AM, Uebelhack R, Pohl U. Efficacy and tolerability of hydrogen carbonate-rich water for heartburn. World J Gastrointest Pathophysiol.2016; 7: 171–180.
- El-Serag HB, Petersen NJ, Carter J, Graham DY, Richardson P, Genta RM, Rabeneck L. Gastroesophageal reflux among different racial groups in the United States.Gastroenterology. 2004;126:1692–1699
- Alireza Delavari A, Moradi Gh, Birjandi F, Elahi E, Saberifiroozi M. The Prevalence of Gastroesophageal Reflux Disease (GERD) in the Islamic Republic of Iran: A Systematic Review Middle East.J Dig Dis.2012; 4: 5–15.
- Vakil N, Van Zanten SV, Kahrilas P, Dent J, Jones R. Global consensus Group. The Montreal definition and classification of gastroesophageal reflux disease .a global evidence –based cosensaus. Am J Gastroentrology 2006;101:1900-1920
- Chen CL, Hsu PI. Current advances in the diagnosis and treatment of nonerosive reflux disease. Gastroenterology research and practice, 2013.
- Tack J, Fass R. Approaches to endoscopicâ€negative reflux disease: part of the GERD spectrum or a unique acidâ€related disorder?. Alimentary pharmacology & therapeutics, 2004; 19:28-34.
- Bredenoord AJ. Impedance-pH monitoring: new standard for measuring gastro-oesophageal reflux.Neurogastroentrology and motility.2008; 20:434-439.
- Savarino E, Pohl D, Zentilin P, Dulbecoo P, Sammito G, Sconfienza L, Vigneri S, Camerini G, Tutuian R, Savarino V. Functional heartburn has more in common with functional dyspepsia than with non-erosive reflux disease.Gut.2009;58:1185-91.
- Patel A, Sayuk GS, Gyawali CP. Acid-Based Parameters on pH-Impedance Testing Predict Symptom Improvement With Medical Management Better Than Impedance Parameters. Am J Gastroenterol 2014;109:836–844.
- Yaseri HF, Yaseri AMF , Moghaddam AB, Arabshhi SKS. Relationship between Esophageal Clinical Symptoms and Manometry Findings in Patients with Esophageal Motility Disorders:A Cross-Sectional Study. Med J Islam Repub Iran 2015; 29:271-272.
- Knowles CH, Aziz Q. Visceral hypersensitivity in nonerosive reflux disease. Gut 2008; 57:674–83.
How to Cite
Fakhre Yaseri, H. (2018). Functional heartburn in Iranian patients with non-erosive gastroesophageal reflux disease. Bali Medical Journal, 7(1), 161–164. https://doi.org/10.15562/bmj.v7i1.811
