Background: Human Immunodeficiency Virus infection is a chronic disease with inflammatory conditions and experience progressive muscle wasting with increasing of tumor necrosis factor alpha. Physical exercise is a non-pharmacological therapy which stimulate the muscle regeneration. Moderate intensity of aerobic exercise is safe for human immunodeficiency virus Â patients. Whether tumor necrosis factor alpha plays a role in the process of muscle regeneration in human immunodeficiency virus Â infection who have had tumor necrosis factor alpha level higherObjective: To explain the role of tumor necrosis factor alpha, NF-kappaB, and Calcineurin expression in the regulation of muscle regeneration process.
Methods: Research subjects are population with clinical stage II human immunodeficiency virus infection. Subjects were grouped in to two: I (n = 9) as subjects who got aerobic exercise for 8 weeks and C (n = 9) as subjects who were observe for 8 weeks. Muscle samples were taken from the vastus lateralis muscle biopsies that were performed 24 hours after the last physical exercise. And the immunohistochemical examination was done with anti- tumor necrosis factor alpha monoclonal antibody, anti- NF-kappaB. and anti-calcineurin.Results: The relationship of muscle contraction to Tumor necrosis factor alpha and calcineurin expression, and to the other myogenic factors was significant, but not to NF-kappaB p65 expression. NF-kappaB p65 has another path.Conclusion: Muscle regeneration process need TNF-alpha, and NF-kB p65 expression as regulators with TNF-alpha_NF-kB p65_myogenic factors as path of exercise and calcineurin expression as regulator with calcineurin_myogenic factors as path of exercise.