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Diagnostics of erythrocytes' microrheological features and early abnormalities of rats in the model of experimental hypertension development

  • Zavalishina Yuryevna ,
  • Yu. A Vatnikov ,
  • E. V Kulikov ,
  • S. A Yagnikov ,
  • A. S Karamyan ,
  • N. V Sturov ,
  • V. M Byakhova ,
  • M. V Kochneva ,
  • A.V Petryaeva ,


Abstract

Difficulties of the earliest stages' detection of erythrocytes' microrheological abnormalities' development at hypertension are connected with falling out of clinicians' field of view of persons with first signs of this pathology. It dictates the necessity of experimental investigations' fulfillment on laboratory animals with just developed hypertension in them. 87 of healthy male-rats of Vistar line at the age of 2,5-3 months were taken into investigation. 29 animals of them had experienced no impacts and composed the control group. 58 rats had hypertension developed by prescribing them cardioangionefopathogenic semisynthetic diet. There were used biochemical, hematological and statistical methods of investigation. As the result of hypertension development the rats turned out to have stable developing increase of systolic and diastolic pressure. At regular exercise on the treadmill the rats were noted to have gradual decrease of their values during 60 days of investigation to the level of norm. During hypertension development lipids' peroxidation activated in rats' erythrocytes because of activity weakening of their antioxidant protection. At hypertension development in rats there was found reliable decrease of erythrocytes-discocytes quantity in blood. It was accompanied by increase of reversibly and irreversibly changed erythrocytes' quantity in examined animals' blood. At hypertension development in rats there was found quick rise of erythrocytes' sum in aggregate and these aggregates' quantity at lowering of free erythrocytes' number. During experimental hypertension modelling we noticed very early in rats' blood decrease of erythrocytes-discocytes' quantity, level rise of their reversibly and irreversibly varieties with strengthening of their aggregative ability. It takes place on the background of weakening of erythrocytes' antioxidant protection and activation of lipids' peroxidation in them.
Keywords: rats erythrocytes microrheological features experiment hypertension.

How to Cite

Yuryevna, Z., Vatnikov, Y. A., Kulikov, E. V., Yagnikov, S. A., Karamyan, A. S., Sturov, N. V., Byakhova, V. M., Kochneva, M. V., & Petryaeva, A. (2017). Diagnostics of erythrocytes’ microrheological features and early abnormalities of rats in the model of experimental hypertension development. Bali Medical Journal, 6(3), 470–475. https://doi.org/10.15562/bmj.v6i3.589
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