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Blighted Ovum: Roles of human leukocyte antigen-E and natural killer cells

  • Sri Sulistyowati ,
  • Febri Rahadian ,
  • Supriyadi Hari Respati ,
  • Soetrisno Soetrisno ,


Background: The failure of premature conception product is a specific problem for pregnant women. Blighted Ovum occurred in 37.5% of early pregnancy failure. About 15% of Blighted Ovum is caused by disorders of the immune system. Human Leukocyte Antigen-E  and Natural Killer Cell  are supposed to be the main factors of this pathomechanism.

Objective: To determine the expression of Human Leukocyte Antigen-E and  Natural Killer Cell cells in the Blighted Ovum and normal pregnancy.

Methods: Observational analytic with cross sectional approach. Thirty-two samples were divided into two groups: 16 samples of Blighted Ovum group and 16 samples of normal pregnancy group.  Human Leukocyte Antigen-E and Natural Killer Cell  cells in trophoblast of both groups were examined with immunohistochemical methods and statistical analysis that was done by t-test.

Results: The mean of expression of  Human Leukocyte Antigen-E in the group of Blighted Ovum are 75.15±6:30, normal pregnancy are 83.13±11:26, p-value=0:02 (P <0.05). The mean of expression of NK cells in the group of a normal pregnancy  is 79.72±6.63, while the mean of expression of NK cells in Blighted Ovum is 93.88±14.08, p-value=0.00 (P<0.05).

Conclusion: The expression of HLA-E was lower, and NK cells were higher in Blighted Ovum when compared with normal pregnancy.



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How to Cite

Sulistyowati, S., Rahadian, F., Respati, S. H., & Soetrisno, S. (2017). Blighted Ovum: Roles of human leukocyte antigen-E and natural killer cells. Bali Medical Journal, 6(2), 381–385.




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Febri Rahadian
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Supriyadi Hari Respati
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Soetrisno Soetrisno
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