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Myocardial pathological changes in overtraining exercise

  • Made Kurnia Widiastuti Giri ,
  • Ketut Indra Purnomo ,
  • Muchsin Doewes ,
  • Bambang Purwanto ,
  • Ambar Mudigdo ,


Background: An overtraining or a practice of an excessive intensity without a sufficient recovery period may induce myocardial injury. Objective: The aim of this study was to reveal myocardial changes in overtrained rats through a histo-pathobiological analysis. Methods: We enrolled 24 male Wistar rats for 6 weeks. As many as 8 rats or the control group swam 15 minute/day, 5 days/week. The overtrained group consisted of 24 rats swam for 90 minutes, twice a day, daily. After sacrificing, the hearts were excised for pathological preparation slides. Results: The overtrained group’s slides showed an increase in chromatin fragmentation in the myocardial structure. The left ventricle wall thickness was also greater in overtrained groups than the control. Necrotic bodies were found in the myocardium of overtrained groups, but none in the control group. Conclusion: We found the negative effects of an overtraining to the myocardium. Avoiding overtraining is necessary to avoid a myocardial injury.


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How to Cite

Giri, M. K. W., Purnomo, K. I., Doewes, M., Purwanto, B., & Mudigdo, A. (2017). Myocardial pathological changes in overtraining exercise. Bali Medical Journal, 6(3), 505–508.




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Made Kurnia Widiastuti Giri
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Ketut Indra Purnomo
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Muchsin Doewes
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Bambang Purwanto
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Ambar Mudigdo
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