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Interleukin-17 expression is associated with survival in pediatric osteosarcoma

  • Muhammad Riza ,
  • Harsono Salimo ,
  • Brian Wasita ,
  • Vitri Widyaningsih ,
  • Bambang Purwanto ,
  • Pamudji Utomo ,
  • Soestrisno Soestrisno ,
  • Fikar Arsyad Hakim ,
  • Fairuz Zahidah ,
  • Janur Wayanshakty ,

Abstract

Link of Video Abstract: https://youtu.be/qXGE9z-UpDs

 

Background: Osteosarcoma is a cancerous tumor that develops from bone-forming mesenchymal cells. The cause of osteosarcoma appears to be multifaceted, and cytokine production is a potential causative factor. T helper 17 cells are responsible for producing the cytokine interleukin 17 (IL-17), and its association with cancer progression remains a subject of ongoing debate. This study aimed to analyze IL-17 expression before and after neoadjuvant chemotherapy and the relationships between prognostic factors and survival.

Methods: We investigated the expression of IL-17 in osteosarcoma tissues from 22 pediatric patients who underwent neoadjuvant chemotherapy. Histopathological and immunohistochemical methods were used to assess IL-17 expression prior to the patients undergoing neoadjuvant chemotherapy. IL-17 expression before chemotherapy was classified as low or high based on the median data. Survival was calculated using the Kaplan–Meier survival analysis with the log-rank test.

Result: The following characteristics were found to be associated with longer survival: male, age > 10 years old, distal location of tumor, low-grade tumor, and tumor with no metastasis; however, there were no statistically significant differences (p > 0.05). Binary logistic analysis showed that high expression of IL-17 based on the median data before neoadjuvant chemotherapy (>1.62%) were significantly associated with reduced survival (p = 0.010). The mean estimated overall duration of survival was 19.4 months (95% confidence interval (CI): 14.5-24.3) for low IL-17 expression and 14.0 months (95%CI: 8.3–19.7) for high IL-17 expression based on the median data. There was no statistically significant difference in the overall survival (p > 0.05).

Conclusion: High expression of IL-17 before neoadjuvant chemotherapy after neoadjuvant chemotherapy were associated with poor survival among pediatric osteosarcoma patients. These findings suggest that IL-17 is a potential prognostic biomarker for pediatric osteosarcoma.

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How to Cite

Riza, M. ., Salimo, H. ., Wasita, B. ., Widyaningsih, V. ., Purwanto, B. ., Utomo, P. ., Soestrisno, S., Hakim, F. A. ., Zahidah, F. ., & Wayanshakty, J. . (2023). Interleukin-17 expression is associated with survival in pediatric osteosarcoma. Bali Medical Journal, 13(1), 270–277. https://doi.org/10.15562/bmj.v13i1.4949

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