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Clinical improvement of gastroesophageal reflux disease (GERD) patients with warm ear stimulation, initial exploratory study on the anterior branch of the vagal nerve (Jacobson's nerve)

Abstract

Link of Video Abstract: https://youtu.be/mVByi-Qg-xo

 

Introduction: Jacobson's nerve, also known as the auricular branch of the vagus nerve, is situated on the medial part of the earlobe. Research has demonstrated that electrical stimulation of this nerve can influence various aspects of gastrointestinal motility and function. This study investigated how warm stimulation affects Jacobson's nerves as an adjuvant therapy in patients with gastroesophageal reflux disease (GERD).

Methods: The investigation was carried out using a single-blind design, wherein the participants were unaware of their assigned group and the nature of the ear-warming therapy they were getting, whether genuine or placebo. The present study involved a sample of 15 individuals who were diagnosed with gastroesophageal reflux and had undergone medical treatment. The participants were allocated into three distinct groups for the study. Group 1 was administered anti-gastritis medication and instructed to utilize ear warmers. Group 2 was given a placebo medication and required a device resembling an ear warmer. Lastly, Group 3 was solely administered anti-gastritis medication without additional ear warmers instructions.

Results: This study showed a significant difference between the three groups after the intervention (p = 0.03). Post-intervention comparison between groups 1 and 3 revealed a significant difference [9 (3-11) vs 15 (14-16), p = 0.008].

Conclusions: Warm stimulation can serve as a viable and secure supplementary therapeutic approach for individuals diagnosed with gastroesophageal reflux disease (GERD).

References

  1. Wang Y, Li SY, Wang D, Wu MZ, He JK, Zhang JL,et al. Transcutaneous auricular vagus nerve stimulation: From concept to application. Neurosci Bull. 2021;37(6):853-62.
  2. Butt MF, Albusoda A, Farmer AD, Aziz Q. The anatomical basis for transcutaneous auricular vagus nerve stimulation. J Anat. 2020;236(4):588–611.
  3. Cirillo G, Negrete-Diaz F, Yucuma D, Virtuoso A, Korai SA, De Luca C, et al. Vagus nerve stimulation: a personalized therapeutic approach for crohn’s and other inflammatory bowel diseases. Cells. 2022;11(24):4103.
  4. Elamin ABA, Forsat K, Senok SS, Goswami N. Vagus nerve stimulation and its cardioprotective abilities: A systematic review. J Clin Med. 2023;12(5):1717.
  5. Gagliardi V, Gagliardi G, Ceccherelli F, Lovato A. Effect of low- and high-frequency auricular stimulation with electro-acupuncture on cutaneous microcirculation: A cross-over study in healthy subjects. Med (Basel, Switzerland). 2023;10(2):17.
  6. Go YY, Ju WM, Lee CM, Chae SW, Song JJ. Different transcutaneous auricular vagus nerve stimulation parameters modulate the anti-inflammatory effects on lipopolysaccharide-induced acute inflammation in mice. Biomedicines. 2022;10(2):247.
  7. Miri S, Yeo J, Abubaker S, Hammami R. Neuromicrobiology, an emerging neurometabolic facet of the gut microbiome? Front Microbiol. 2023;14:1098412.
  8. Venborg J, Wegeberg AM, Kristensen S, Brock B, Brock C, Pfeiffer-Jensen M. The effect of transcutaneous vagus nerve stimulation in patients with polymyalgia rheumatica. Pharmaceuticals (Basel). 2021;14(11):1166.
  9. Yetis O, Guner O, Akkaya I, Guneli E, Bagriyanik A, Tozburun S. Vagus nerve bundle stimulation using 1505-nm laser irradiation in an in-vivo rat model. J Biophotonics. 2022;15(1):e202100197.
  10. Ylikoski J, Markkanen M, Pirvola U, Lehtimäki JA, Ylikoski M, Jing Z, et al. Stress and tinnitus; Transcutaneous auricular vagal nerve stimulation attenuates tinnitus-triggered stress reaction. Front Psychol. 2020;11:570196.
  11. Li R, Hu H, Luo N, Fang J. Bibliometric analysis of publication trends and research hotspots in vagus nerve stimulation: A 20-year panorama. Front Neurol. 2022;13:1045763.
  12. Shaw M, Dent J, Beebe T, Junghard O, Wiklund I, Lind T, et al. The Reflux Disease Questionnaire: a measure for assessment of treatment response in clinical trials. Health Qual Life Outcomes. 2008;6:31.
  13. Suherman LP, Ramdani R, Septiani V, Indrayani W, Islamiyah AN, Hasyim PR. Pola penggunaan obat pada pasien gastroesophageal reflux disease (GERD) di salah satu rumah sakit di Bandung. Pharmacoscript. 2021;4(2):208-19.
  14. Amazon. Aroma Season Heated Ear Warmer for Winter Women & Men Electric Warm Ear Muf Fleece Ear Covers Band Adjustable [Internet]. Available from: https://www.amazon.com/Heated-Warmer-Running-Electric-Weather/dp/B08FM8854J.
  15. Sandhu DS, Fass R. Current trends in the management of gastroesophageal reflux disease. Gut Liver. 2018;12(1):7–16.
  16. Gottfried-Blackmore A, Habtezion A, Nguyen L. Noninvasive vagal nerve stimulation for gastroenterology pain disorders. Pain Manag. 2021;11(1):89–96.
  17. Diedrich A, Urechie V, Shiffer D, Rigo S, Minonzio M, Cairo B, et al. Transdermal auricular vagus stimulation for the treatment of postural tachycardia syndrome. Auton Neurosci Basic Clin. 2021;236:1–24.
  18. Choi S, Jang DC, Chung G, Kim SK. Transcutaneous auricular vagus nerve stimulation enhances cerebrospinal fluid circulation and restores cognitive function in the rodent model of vascular cognitive impairment. Cells. 2022;11(19):3019.
  19. Corrêa FI, Souza PHL, Uehara L, Ritti-Dias RM, Oliveira da Silva G, Segheto W, et al. Transcutaneous auricular vagus nerve stimulation improves inflammation but does not interfere with cardiac modulation and clinical symptoms of individuals with COVID-19: A randomized clinical trial. Life (Basel, Switzerland). 2022;12(10):1644.
  20. Zhang S, He JK, Zhong GL, Wang Y, Zhao YN, Wang L, et al. Prolonged longitudinal transcutaneous auricular vagus nerve stimulation effect on striatal functional connectivity in patients with major depressive disorder. Brain Sci. 2022;12(12):1730.
  21. Wu Y, Song L, Wang X, Li N, Zhan S, Rong P, et al. Transcutaneous vagus nerve stimulation could improve the effective rate on the quality of sleep in the treatment of primary insomnia: A randomized control trial. Brain Sci. 2022;12(10):1296.
  22. Krusche-Mandl I, Kaider A, Starlinger J, Preschitz M, Schuster R, Kefurt R, et al. Implementation of electrical auricular acupuncture and low frequency modulated electric current therapy in pain management of patients with knee osteoarthritis: A randomized pilot trial. J Clin Med. 2019;8(8):1229.
  23. Karemaker JM. The multibranched nerve: vagal function beyond heart rate variability. Biol Psychol. 2022;172:108378.
  24. Hou L, Rong P, Yang Y, Fang J, Wang J, Wang Y, et al. Auricular vagus nerve stimulation improves visceral hypersensitivity and gastric motility and depression-like behaviors via vago-vagal pathway in a rat model of functional dyspepsia. Brain Sci. 2023;13(2):253.
  25. Yakunina N, Nam EC. Direct and transcutaneous vagus nerve stimulation for treatment of tinnitus: A scoping review. Front Neurosci. 2021;15:680590.
  26. Kong J, Fang J, Park J, Li S, Rong P. Treating depression with transcutaneous auricular vagus nerve stimulation: State of the art and future perspectives. Front psychiatry. 2018;9:20.
  27. Evensen K, Jørgensen MB, Sabers A, Martiny K. Transcutaneous vagal nerve stimulation in treatment-resistant depression: A feasibility study. Neuromodulation. 2022;25(3):443–9.
  28. Fedak KM, Bernal A, Capshaw ZA, Gross S. Applying the Bradford Hill criteria in the 21st century: how data integration has changed causal inference in molecular epidemiology. Emerg Themes Epidemiol. 2015;12:14.
  29. Kim AY, Marduy A, de Melo PS, Gianlorenco AC, Kim CK, Choi H, et al. Safety of transcutaneous auricular vagus nerve stimulation (taVNS): A systematic review and meta-analysis. Sci Rep. 2022;12(1):22055.

How to Cite

Saleh, A. Y. ., Zakaria, H. ., Allya Paramita Koesoema, Retno Yulianti, Prabowo, I. ., & Taufiq Fredrik Pasiak. (2023). Clinical improvement of gastroesophageal reflux disease (GERD) patients with warm ear stimulation, initial exploratory study on the anterior branch of the vagal nerve (Jacobson’s nerve). Bali Medical Journal, 13(1), 311–316. https://doi.org/10.15562/bmj.v13i1.4947

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Arman Yurisaldi Saleh
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Hasballah Zakaria
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Allya Paramita Koesoema
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Retno Yulianti
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Imam Prabowo
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Taufiq Fredrik Pasiak
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