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Hypoalbuminemia in burn patients with COVID-19: a cross-sectional study

  • Heri Noviana ,
  • Iswinarno Doso Saputro ,
  • Ira Handriani ,

Abstract

Link of Video Abstract: https://youtu.be/onpoWqpxn5Q

 

Background: Burns contributes substantially to illness and death rates in underdeveloped nations. Hypoalbuminemia is a medical disorder that has been observed in both burn patients and individuals diagnosed with COVID-19. Hypoalbuminemia has been observed to exacerbate the severity of burn injuries and potentially COVID-19 infections. This retrospective study aimed to examine the disparity in hypoalbuminemia occurrence and its association with mortality among burn patients, specifically focusing on those infected with and without COVID-19.

Methods: The present investigation is a retrospective cross-sectional study examining the disparities in hypoalbuminemia occurrence and its association with mortality among burn patients with or without COVID-19. The study was conducted at Dr. Soetomo General Hospital in Surabaya, covering the time frame from March 2020 to December 2022.

Results: Among a cohort of 225 individuals who presented with acute phase burns, both with and without COVID-19, a total of 125 patients (57.1%) were seen to develop hypoalbuminemia during their treatment at Dr. Soetomo General Hospital between March 2020 and December 2022. This study found no statistically significant disparity in mean albumin levels and mortality outcomes between acute-phase burn patients with COVID-19 and those without COVID-19 who experienced hypoalbuminemia. Nevertheless, notable disparities (p<0.05) were seen in terms of age, length of stay (LOS), and severity of burns among hypoalbuminemia patients who were discharged from the hospital (KRS) for outpatient care and those who succumbed to their condition.

Conclusion: Our findings indicate no statistically significant disparity in albumin levels and mortality rates among burn patients, regardless of whether they are also diagnosed with COVID-19. Nevertheless, variables such as age, length of stay (LOS), and burn area exhibit notable variations in the outcome of death.

References

  1. Dewi PSR, Adnyana MS, Subawa IW. Studi Penggunaan Albumin Pada Pasien Luka Bakar Derajat Ii Sampai Iii Di Rsup Sanglah Denpasar Periode 2016-2017. Jurnal Medika Udayana. 2019;8(9):1-10.
  2. Dewi R, Kaltha K, Wardhana A, Yanuarso PB. Association Between Serum Albumin And The Success Of Fluid Resuscitation In Children Hospitalized In Cipto Mangunkusumo Hospital Burn Center. Jurnal Plastik Rekonstruksi. 2018;2(1):226-233.
  3. Lopez AB, Murillo GA, Neciosup AM, Rios EG. Hypoalbuminemia as a predictor of mortality of sepsis from COVID-19. Hospital II Chocope. Rev Fac Med Hum. 2021;21(1):12-18.
  4. Soetedjo NNM, Iryaningrum MR, Damara FA, Permadhi I, Sutanto LB, Hartono H, et al. Prognostic properties of hypoalbuminemia in COVID-19 patients: A systematic review and diagnostic meta-analysis. Clinical Nutrition ESPEN. 2021;45(1):120-126.
  5. Suharjono, Annura S, Saputro ID, Rusiani DR. Evaluasi Penggunaan Albumin Pada Pasien Luka Bakar di RSUD Dr. Soetomo. Prosiding Rakernas dan Pertemuan Ilmiah Tahunan Ikatan Apoteker Indonesia 2016;1(1):2541-0474
  6. Erstad BL. Albumin disposition in critically Ill patients. J Clin Pharm Ther. 2018;43(1):746–751
  7. Martini WZ, Wolf SE, Chinkes DL, Chung KK, Dubick MA, Blackbourne L, et al. Enhanced Albumin Synthesis In Severely Burned Adults. SHOCK. 2010;34(4):364-368.
  8. Pérez-Guisado J, de Haro-Padilla JM, Rioja LF, Derosier LC, de la Torre JI. Serum albumin levels in burn people are associated to the total body surface burned and the length of hospital stay but not to the initiation of the oral/enteral nutrition. International Journal of Burns and Trauma. 2013;3(3):159-163
  9. Odunayo A. Albumin and colloid osmotic pressure. In Monitoring and Intervention for the Critically Ill Small Animal. Wiley. 2016;1(1):43–53.
  10. Liu K, Chen Y, Lin R, Han K. Clinical features of COVID-19 in elderly patients: a comparison with young and middle-aged patients. J Infect. 2020;80(1):e14-8.
  11. Anam K, Dachlan I. Prognostic factors affecting the mortality of burn injuries patients in Dr. Sardjito General Hospital, Yogyakarta, Indonesia. J Med Sci. 2018;50(2):201-208.
  12. Hasibuan MIA, Moenadjat Y. Prognostic and Predictive Factors of Mortality in Burn Patients at dr. Cipto Mangunkusumo General Hospital, Indonesia. The New Ropanasuri Journal of Surgery. 2021;6(2):4.
  13. AbdelWahab ME, Sadaka MS, Elbana EA, Hendy AA. Evaluation of prognostic factors affecting length of stay in hospital and mortality rates in acute burn patients. Annals of Burns and Fire Disasters. 2018;31(2):83–88.
  14. Dharma BDA, Mulyantari NK, Prabawa IPY. Analisis korelasi kadar serum prokalsitonin dengan jumlah leukosit pada penderita dengan kecurigaan sepsis di RSUP Sanglah, Bali, Indonesia. Intisari Sains Medis. 2020;11(1):179-182.
  15. Muthiah U, Rostini T, Tristina N. The role of serum albumin level within the first 24-hours of hospitalization to the mortality risk in burn patients at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. Bali Medical Journal. 2019;8(2):499–504.
  16. Christie CD. Profil dan angka mortalitas pasien anak dengan luka bakar di Unit Luka Bakar Rumah Sakit Umum Pusat Nasional Ciptomangunkusumo [Thesis]. [Jakarta]: Universitas Indonesia. 2017.
  17. Lashgari MH, Rostami MHH, Etemad O. Assessment of outcome of using amniotic membrane enriched with stem cells in scar formation and wound healing in patients with burn wounds. Bali Medical Journal. 2019;8(1):41–46.
  18. Sudarsa PSS, Puspawati NMD, Purnama NKR, Sanjaya IGPH, Hamid ARRH. Toxic Epidermal Necrolysis (TEN) in an elderly with comorbidities: a case report. Bali Medical Journal. 2020;9(1):323–326.

How to Cite

Noviana, H., Saputro, I. D., & Handriani, I. (2023). Hypoalbuminemia in burn patients with COVID-19: a cross-sectional study. Bali Medical Journal, 12(3), 3201–3205. https://doi.org/10.15562/bmj.v12i3.4768

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