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The α-smooth muscle actin (α-SMA) and collagen type III expression of Platelet Rich Fibrin (PRF) membrane in conjunctival wound healing: a literature review

  • Agung Bhakti Wiratama ,
  • Reni Prastyani ,
  • Indri Wahyuni ,
  • Thomas Valentinus ,
  • Hari Basuki Notobroto ,


Link of Video Abstract:


The platelet-rich fibrin (PRF) membrane represents a new reconstructive material employed in ocular surface procedures. Platelet-rich fibrin (PRF) offers several notable benefits, including its potential to mitigate inflammation, its abundance of growth factors, and its capacity to serve as a transient framework for fibroblast migration. Nevertheless, despite the numerous benefits it offers, PRF is not extensively utilized in comparison to alternative methods like conjunctival autograft. The utilization of conjunctival autograft has been a longstanding approach in ocular surface reconstruction methodologies; however, it is not without its inherent limitations. Therefore, the utilization of the PRF membrane technique presents a viable solution for addressing this particular scenario. This literature review aims to present a comprehensive analysis of the role of PRF in the regulation of inflammation and its potential to facilitate the healing of conjunctival wounds. This review is expected to stimulate further experimental investigations into the influence of α-SMA and collagen type III expression on the efficacy of PRF membranes in promoting conjunctival wound healing.


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How to Cite

Wiratama, A. B., Prastyani, R., Wahyuni, I., Valentinus, T., & Notobroto, H. B. (2023). The α-smooth muscle actin (α-SMA) and collagen type III expression of Platelet Rich Fibrin (PRF) membrane in conjunctival wound healing: a literature review. Bali Medical Journal, 12(3), 2538–2547.




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Agung Bhakti Wiratama
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Reni Prastyani
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Indri Wahyuni
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Thomas Valentinus
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Hari Basuki Notobroto
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