Skip to main content Skip to main navigation menu Skip to site footer

Progesterone Serum Level on HCG Trigger Day among Frozen Embryo Transfer IVF Patients and Pregnancy Outcomes: A Systematic Review and Meta-Analysis



Abstract

Abstract: The association between progesterone serum levels on the day of hCG administration and IVF pregnancy outcomes has been the subject of numerous studies and clinical investigations. We aim to conduct a systematic review and meta-analysis to explore the influence of progesterone serum levels on hCG trigger day on pregnancy outcomes in vitro fertilization (IVF) cycles. Through a comprehensive search of the PubMed and Embase databases, eight studies were identified for inclusion. The analysis revealed a risk ratio for live birth rate of 0.91 (95% CI 0.79-1.06), clinical pregnancy rate of 1.01 (95% CI 0.89-1.15), miscarriage rate: 0.98 (95% CI 0.80-1.21), implantation rate 0.81 (95% CI 0.49-1.35), and mean difference for endometrial thickness -0.01 (95% CI -0.16, 0.14). This study showed insignificant progesterone serum levels on the day of hCG administration and IVF pregnancy outcomes. However, the heterogeneity across studies emphasizes the need for larger, standardized investigations to elucidate the nuanced associations between progesterone levels and IVF success. This study contributes to our understanding of the role of progesterone in IVF outcomes and provides a basis for future research to optimize fertility treatment protocols.

Keywords: HCG Day IVF Pregnancy Outcome Progesterone

References

  1. Eskew AM, Jungheim ES. A history of developments to improve in vitro fertilization. Mo Med. 2017;114:156-9.
  2. Amini P, Ramezanali F, Parchehbaf-Kashani M, Maroufizadeh S, Omani-Samani R, Ghaheri A. Factors associated with in vitro fertilization live birth outcome: A comparison of different classification methods. Int J Fertil Steril. 2021;15:128-34.
  3. Bulletti C, Bulletti FM, Sciorio R, Guido M. Progesterone: The key factor of the beginning of life. Int J Mol Sci. 2022;23.
  4. Li R, Qiao J, Wang L, Zhen X, Lu Y. Serum progesterone concentration on day of hcg administration and ivf outcome. Reprod Biomed Online. 2008;16:627-31.
  5. Kolatorova L, Vitku J, Suchopar J, Hill M, Parizek A. Progesterone: A steroid with wide range of effects in physiology as well as human medicine. Int J Mol Sci. 2022;23.
  6. Robati S, Saab W, Durán-Retamal M, Saab W, Theodorou E, Cawood S, et al. The association between elevated progesterone level on day of hcg trigger and live birth rates in art cycles: A single centre observational study. J Reprod Infertil. 2020;21:283-90.
  7. Kong N, Liu J, Jiang Y, Zhu Y, Zhang C, Yan G, et al. Adverse impact of elevated progesterone levels on human chorionic gonadotropin trigger day on blastocyst transfer outcomes in gonadotropin-releasing hormone agonist cycles. Eur J Obstet Gynecol Reprod Biol. 2022;276:107-12.
  8. Liang YX, Liu L, Jin ZY, Liang XH, Fu YS, Gu XW, et al. The high concentration of progesterone is harmful for endometrial receptivity and decidualization. Sci Rep. 2018;8:712.
  9. Kim YJ, Shin JH, Hur JY, Kim H, Ku SY, Suh CS. Predictive value of serum progesterone level on β-hcg check day in women with previous repeated miscarriages after in vitro fertilization. PLoS One. 2017;12:e0181229.
  10. Pouya K, Şükür YE, İsrafilova G, Özmen B, Sönmezer M, Berker B, et al. Hcg day progesterone level has no impact on the frozen thawed embryo transfer cycle outcome. J Gynecol Obstet Hum Reprod. 2021;50:102120.
  11. Li J, Cui Y, Shi H, Bu Z, Wang F, Sun B, et al. Effects of trigger-day progesterone in the preimplantation genetic testing cycle on the embryo quality and pregnancy outcomes of the subsequent first frozen-thawed blastocyst transfer. Front Endocrinol (Lausanne). 2023;14:990971.
  12. Baldini D, Savoia MV, Sciancalepore AG, Malvasi A, Vizziello D, Beck R, et al. High progesterone levels on the day of hcg administration do not affect the embryo quality and the reproductive outcomes of frozen embryo transfers. Clin Ter. 2018;169:e91-e5.
  13. Wu Z, Li R, Ma Y, Deng B, Zhang X, Meng Y, et al. Effect of hcg-day serum progesterone and oestradiol concentrations on pregnancy outcomes in gnrh agonist cycles. Reprod Biomed Online. 2012;24:511-20.
  14. Kofinas JD, Mehr H, Ganguly N, Biley Y, Bochkovsky S, McCulloh D, et al. Is it the egg or the endometrium? Elevated progesterone on day of trigger is not associated with embryo ploidy nor decreased success rates in subsequent embryo transfer cycles. J Assist Reprod Genet. 2016;33:1169-74.
  15. Urman B, Alatas C, Aksoy S, Mercan R, Isiklar A, Balaban B. Elevated serum progesterone level on the day of human chorionic gonadotropin administration does not adversely affect implantation rates after intracytoplasmic sperm injection and embryo transfer. Fertil Steril. 1999;72:975-9.
  16. Silverberg KM, Martin M, Olive DL, Burns WN, Schenken RS. Elevated serum progesterone levels on the day of human chorionic gonadotropin administration in in vitro fertilization cycles do not adversely affect embryo quality. Fertil Steril. 1994;61:508-13.
  17. Aimagambetova G, Issanov A, Terzic S, Bapayeva G, Ukybassova T, Baikoshkarova S, et al. The effect of psychological distress on ivf outcomes: Reality or speculations? PLoS One. 2020;15:e0242024.
  18. Mumusoglu S, Polat M, Ozbek IY, Bozdag G, Papanikolaou EG, Esteves SC, et al. Preparation of the endometrium for frozen embryo transfer: A systematic review. Front Endocrinol (Lausanne). 2021;12:688237.
  19. Beck-Fruchter R, Nothman S, Baram S, Geslevich Y, Weiss A. Progesterone and estrogen levels are associated with live birth rates following artificial cycle frozen embryo transfers. J Assist Reprod Genet. 2021;38:2925-31.
  20. Paulson RJ. Hormonal induction of endometrial receptivity. Fertil Steril. 2011;96:530-5.
  21. Greene AD, Patounakis G, Segars JH. Genetic associations with diminished ovarian reserve: A systematic review of the literature. J Assist Reprod Genet. 2014;31:935-46.
  22. Wu J, Liu Y, Song Y, Wang L, Ai J, Li K. Aging conundrum: A perspective for ovarian aging. Front Endocrinol (Lausanne). 2022;13:952471.
  23. Pokulniewicz M, Issat T, Jakimiuk A. In vitro fertilization and age. When old is too old? Prz Menopauzalny. 2015;14:71-3.
  24. Neamtiu IA, Surcel M, Begum TF, Gurzau ES, Berindan-Neagoe I, Braicu C, et al. Specific lifestyle factors and in vitro fertilization outcomes in romanian women: A pilot study. PeerJ. 2022;10:e14189.
  25. Martin CE, Lanham M, Almgren-Bell A, Marsh C, Omurtag K. A randomized controlled trial to evaluate the use of a web-based application to manage medications during in vitro fertilization. Fertil Steril. 2021;116:793-800.
  26. Zhao J, Hao J, Xu B, Wang Y, Li Y. Effect of slightly elevated progesterone on hcg trigger day on clinical pregnancy rate in gnrh-ant ivf/icsi cycles. Reproductive Health. 2022;19:66.

How to Cite

Herida, A. R., & Muhamad Faza Soelaeman. (2023). Progesterone Serum Level on HCG Trigger Day among Frozen Embryo Transfer IVF Patients and Pregnancy Outcomes: A Systematic Review and Meta-Analysis. Bali Medical Journal, 12(3), 2548–2554. https://doi.org/10.15562/bmj.v12i3.4726
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver
Download Citation
Endnote/Zotero/Mendeley (RIS) BibTeX

HTML
1

Total
1

Share

Search Panel

Alifia Ramadhani Herida
Google Scholar
Pubmed
BMJ Journal

Muhamad Faza Soelaeman
Google Scholar
Pubmed
BMJ Journal