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Leucocytes, thrombocytes and immature platelets in patients with dengue hemorrhagic fever


Diagnosis of Dengue Hemorrhagic Fever (DHF) is based on clinical and supporting examinations, including leukocytes and platelets examinations and antigen and antibody tests for the dengue virus. Examining leucocytes, thrombocytes, and immature platelets is a routine protocol in DHF patients. Leucocytes, thrombocytes, and immature platelets in dengue hemorrhagic fever have their characteristics and roles in relation to the disease severity. Prompt and early diagnosis will reduce the risk of disease severity. This review described the characteristics and role of leucocytes, thrombocytes, and immature platelets in dengue hemorrhagic fever.


  1. Rapp C. Dengue fever: an emerging infectious disease. Rev Prat, 2020; 70(3):318-25.
  2. Ministry of Health RI. Indonesia Health Profile 2020. Available from:
  3. Muller DA, Alexandra CID, and Paul RY. Clinical and Laboratory Diagnosis of Dengue Virus Infection. Journal of Infectious Diseases, 2017; 215 (2): 89–95.
  4. Narasimhan D, Katragadda S, and Sathish M. Retrospective study of white blood cell count and hematocrit in dengue fever. International Journal of Advances in Medicine, 2018; 5(1): 1-3.
  5. Gandini M, Fabienne P, Cíntia FM, Gladys C, Luzia MO, Luiz JS, Rivaldo VC, Claire FK, and Elzinandes LA. Dengue Virus Induces NK Cell Activation through TRAIL Expression during Infection. Journal of Mediators of Inflammation, 2017; (5649214): 1-10.
  6. Alzate JFA, Izabela A, Rodenhuis Z, Juan CH, Jolanda MS, and Silvio UI. Human macrophages differentiated in the presence of vitamin D 3 restrict dengue virus infection and innate responses by downregulating mannose receptor expression. Journal of PLOS Neglected Tropical Diseases, 2017; (11): 1–18.
  7. Krishnamurthy V and Doreswamy SM. Original Article Thrombocytopenia in Dengue Illness : Destruction , Suppression and Composite Platelet Index : A Retrospective Study. Pacific E Journal, 2016; (1): 1-7.
  8. Azeredo DEL, Monteiro RQ, and Pinto LM. Thrombocytopenia in Dengue : Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators. Journal of Mediators of Inflammation, 2015; (313842): 1-16.
  9. Chanthick C, Aroonroong S, Nantapon R, and Pattanakitsakul S. Transcytosis involvement in transport system and endothelial permeability of vascular leakage during dengue virus infection. Journal of Viruses, 2018; (2): 1-12.
  10. Ojha A, Dipika N, Harish B, Rashi S, Gowtham KA, Sankar B, Tulika S, Lalit D, Guruprasad RM, Sudhanshu V, Naval K, Vikram, and Prasenjit G. Platelet activation determines the severity of thrombocytopenia in dengue infection. Journal of Scientific Reports, 2017; (7): 1–10.
  11. Kumar N, Mayuri S, Shrijeet C, Jyothi K, Tanwi S, Bhawana S, and Sharvani S. Correlation of Mean Platelet Volume and Platelet Distribution Width in Risk Categories of Dengue Fever- a Pilot Study. Journal of Evolution of Medical and Dental Sciences, 2018; 7(02): 142–5.
  12. Elmy Saniathi NK, Djoko Rianto BU, Juffrie M, Soetjiningsih S. Dengue hemorrhagic fever: The role of Soluble E-Selektin, Soluble Intra Cellular Adhesion Molecule-1 (Sicam-1) and Soluble Vascular Cellular Adhesion Molecule -1 (Svcam-1) in overweight children. Bali Med J. [Internet]. 2018 Dec. 20 [cited 2023 Jun. 30];8(1):183-7. Available from:
  13. Triningrat AAMP, Agus Somia IK, Dwi Lingga Utama IM, Sri Yuliastini NPN, Wijayati MP, Handayani AT. Dengue hemorrhagic fever with severe ocular complication: case series. Bali Med J. [Internet]. 2020 Dec. 1 [cited 2023 Jun. 30];9(3):907-11. Available from:
  14. Pinontoan OR, Sumampouw OJ, Ticoalu J, Nelwan JE, Musa EC, Sekeeon J. The variability of temperature, rainfall, humidity and prevalance of dengue fever in Manado City. Bali Med J. [Internet]. 2022 Feb. 21 [cited 2023 Jun. 30];11(1):81-6. Available from:

How to Cite

Setiawan, A. F., Yuyun Yueniwati Prabowowati Wajib, Kusworini Handono, & Setyawan Purnomo Sakti. (2023). Leucocytes, thrombocytes and immature platelets in patients with dengue hemorrhagic fever. Bali Medical Journal, 12(2), 2067–2069.




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Ahmad Fahrudi Setiawan
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BMJ Journal

Yuyun Yueniwati Prabowowati Wajib
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Kusworini Handono
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Setyawan Purnomo Sakti
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