Introduction: Someone who is overweight has the potential to experience complications from various diseases which become a heavy economic burden for the community. Dietary modification is considered as one of the strategies to prevent and handling obesity. It can be done by adjust the type, amount, frequency, processing methods, and schedule. Maintenance of intestinal microflora can be done by regulating food intake by consuming foods or drinks that have physiological functions for health. Synbiotics can control the number of good micro-flora in the digestive tract, thus providing health and therapeutic benefits. The aim of this study was to see the effectiveness of milk kefir plus sorghum flour on maintain the cholesterol and blood glucose levels of mice that have been fed a high-fat diet or induced obesity.
Methods: This type of research design is true experimental in vivo using a randomized controlled pre-test-post-test control group design. Based on the test results using one way ANOVA statistical test which can be seen, it can be concluded that there are differences in blood glucose levels in the treatment group using the COD-PAP method with a p-value of 0,031.
Results: According to ANOVA test, there are differences in total cholesterol levels in the treatment group using the CHOD-PAP method with a p-value of 0,000.
Conclusion: There are differences in blood glucose and total cholesterol levels in mice fed kefir milk with the addition of sorghum flour.