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Role of liver damage on glucose metabolism in a lipopolysaccharide-induced mouse model

Abstract

Introduction: The multi-organ damage brought on by sepsis' bacterial infection process makes it a significant cause of death in hospitals. The inflammatory process is triggered by LPS, which is produced by bacterial infection. LPS protects against liver damage, however its exact mechanism is still unknown. The purpose of this investigation is to quantify the extent of liver damage and insulin receptor expression in LPS-induced animal models.

Methods: Eight-week-old male mice were separated into three groups: control group (Group 1), LPS injection group (10 mg/Kg body weight for 4 hours), and LPS injection group (10mg/Kg body weight for 8 hours). Blood sugar and weight are measured as part of the examination of metabolism. To check for liver damage, histology was done.

Results: In comparison to the control group, long-term LPS injection significantly decreased body weight and blood sugar levels (P < 0.05). Based on the high liver damage score in groups 2 and 3 compared to the control group (P < 0.05), this LPS induction also caused harm to the liver's ability to operate.

Conclusion: As a consequence of our research, we may infer that LPS injection damages the liver and produces metabolic abnormalities that are characterized by weight loss and low blood glucose levels.

References

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How to Cite

Hotimah Masdan Salim, Evi Sylvia Awwalia, Sobihatus Syifak, Danny Irawan, & Ilham Putera Alam. (2021). Role of liver damage on glucose metabolism in a lipopolysaccharide-induced mouse model. Bali Medical Journal, 12(3), 3337–3339. https://doi.org/10.15562/bmj.v12i3.4416

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Hotimah Masdan Salim
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Evi Sylvia Awwalia
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Sobihatus Syifak
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Danny Irawan
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Ilham Putera Alam
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