Introduction: Many studies have found the effect of Mozart’s music on the spatial memory of humans, but there are still very few studies that examine the effect of the Murotal Alquran approach on spatial memory improvement. This study aimed to evaluate the effect of Mozart's classical music and the Murotal approach on improving spatial memory in mice. This is an experimental study with 24 adult BALB/c male mice.
Method: The mice were divided into four groups: K (untreated control), P1 (Murotal approach with surah Al-Fatihah and Al-Baqarah by Qori' Al-Mathrud), P2 (Mozart’s classical music approach "Sonata in D for two pianos KV448-Allegro con spirito"), and P3 (combined approach). Each group was placed in a cage and treated for 2 hours/day for 20 days. The memory level was measured with an eight-arm radial maze instrument for ten days. The data were analyzed with non-parametric Kruskal Wallis and Mann-Whitney tests.
Result: This study found there were no significant differences between groups toward increasing spatial memory. The highest and fastest memory score was in the P3 group compared to the others.
Conclusion: There is no difference in the effect between classical music Mozart’s and Murotal approach on increasing the spatial memory of mice (Mus musculus), but mice given a combination of approaches have a better level of spatial memory with a higher level of aggressiveness.