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Association between polymorphism loci rs7041, rs4588 in vitamin D-binding protein receptor gene with comorbid with mortality sepsis patients in intensive care unit General Hospital M. Djamil Padang, West Sumatra

  • Liliriawati Ananta Kahar ,
  • Yusrawati ,
  • Jamsari ,
  • Tinni Maskoen ,
  • Delmi Sulastri ,
  • Yusticia Katar ,
  • Raveinal ,
  • Fika Tri Anggraini ,
  • Kornelis Aribowo ,
  • Wiwi Monika Sari ,


Abstract

Background: Many factors influence the disease, one of which is comorbidity. Comorbid is a condition in which a person simultaneously suffers from two or more diseases. The disease is generally chronic. Patients with comorbid diseases are more at risk of experiencing increased healthcare costs, experiencing obstacles in the healing process, and even death. Loci rs7041 and rs4588 polymorphism of VDBP receptor gene contributed to the pathogenesis of sepsis patients. According to several previous studies, Vitamin D levels and comorbidities affected the mortality of sepsis patients. Several previous studies had linked VDBP with mortality in sepsis. This study aimed to determine the relationship between the loci rs7041 and rs4588 polymorphism and comorbidities with the mortality of sepsis patients.

Method: This research was a descriptive observational study with a prospective cohort design. The total data for this study were 80 samples, consisting of 40 samples of Vitamin D deficiency and 40 samples of non- deficiency Vitamin D. Data were analyzed using the Chi-Square test or the fisher test.

Result: The average age of patients with vitamin D deficiency was 56 years, for females (77,5%), mean APACE II score (20), and mean SOFA score (7). Non-deficient vitamin D with an average age of 50 years, males (70,0%), mean APACE II score (18) and mean SOFA score (5). Diabetes mellitus was the highest comorbidities in rs7041 locus polymorphism (80,0%), underweight in rs4588 locus polymorphism (66,7%) and obesity for non-survival events (64,3%). There was no significant association between comorbidities and rs7041 locus polymorphism, rs4588 locus polymorphism and severity sepsis patients with pValue > 0,05.

Conclusion: Obesity is the highest comorbid for mortality in sepsis patients, but loci rs7041 and rs4588 polymorphisms have no relation to comorbidities.

Keywords: mortalitas obesitas polimorfisme rs7041 rs4588 sepsis

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How to Cite

Ananta Kahar, L., Yusrawati, Jamsari, Tinni Maskoen, Delmi Sulastri, Yusticia Katar, Raveinal, Fika Tri Anggraini, Kornelis Aribowo, & Wiwi Monika Sari. (2023). Association between polymorphism loci rs7041, rs4588 in vitamin D-binding protein receptor gene with comorbid with mortality sepsis patients in intensive care unit General Hospital M. Djamil Padang, West Sumatra. Bali Medical Journal, 12(1), 761–766. https://doi.org/10.15562/bmj.v12i1.4148
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