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Association of appetite hormone levels with HbA1c in obese type-2 diabetes mellitus patients

  • Edward Kurnia Setiawan Limijadi ,
  • Nyoman Suci Widyastiti ,
  • Meita Hendrianingtyas ,
  • Banundari Rachmawati ,

Abstract

Background: Nesfatin-1 and leptin are hormones that control appetite and affect glycemic control. Nesfatin-1 and leptin levels are affected by body mass index (BMI). Hemoglobin A1c (HbA1c) is an objective parameter to assess long-term glycemic control. This present research aims to know the relationship between levels of nesfatin-1 and leptin with HbA1c values ​​as an indicator of long-term objective glycemic control in patients with T2DM with obesity.

Methods: Cross-sectional study on 54 obese T2DM subjects. Measurement of nesfatin-1 and leptin levels using the enzyme linked immunosorbent assay (ELISA) method. The value of HbA1c was measured by the fluorescent immunoassay (FIA) method. The correlation between nesfatin-1 and leptin with Hb1c was tested using the Spearman correlation analysis test (p <0.05 was considered significant).

Results: The median value of nesfatin-1 levels was 1,824.0 (134.0-5,255.0) pg/mL, the median value of leptin levels was 14.0 (0.4 - 66.4) ng/mL, and the median value of HbA1c was 7.70 (4.9-15.0)%. There is no correlation between nesfatin-1 levels and HbA1c values (p = 0.282 and r = 0.149). There is no correlation between leptin levels and HbA1c values (p value = 0.895 and r = 0.018).

Conclusion: HbA1c levels are not associated with an increased appetite, as evidenced by no association between appetite biomarkers and glycemic control.

References

  1. Kementerian Kesehatan RI. Data dan Informasi: Profil Kesehatan Indonesia 2019. 2020.
  2. World Health Organization. Diabetes [Internet]. Fact Sheet. 2020 [cited 2020 Nov 18]. Available from: https://www.who.int/news-room/factsheets/detail/diabetes.
  3. Al-Goblan AS, Al-Alfi MA, Khan MZ. Mechanism linking diabetes mellitus and obesity. Diabetes, Metab Syndr Obes Targets Ther. 2014;7:587–91.
  4. Ford ES, Mokdad AH. Epidemiology of Obesity in the Western Hemisphere. J Clin Endocrinol Metab. 2008;93(11):1–8.
  5. Bandaru P, Shankar A. Association between plasma leptin levels and diabetes mellitus. Metab Syndr Relat Disord. 2011;9(1):19–23. Woods SC, D’Alessio DA. Central control of body weight and appetite. J Clin Endocrinol Metab. 2008;93(11):37–50.
  6. Baratta M. Leptin-from a signal of adiposity to a hormonal mediator in peripheral tissues. Med Sci Moni. 2002;8:282–92.
  7. Kelesidis T, Kelesidis I, Chou S, Mantzoros CS. Narrative review: The role of leptin in human physiology: Emerging clinical applications. Ann Intern Med. 2010;152(2):93–100.
  8. Myers MG, Cowley MA, Münzberg H. Mechanisms of leptin action and leptin resistance. Annu Rev Physiol. 2008;70:537–56.
  9. Ayada C, Toru Ü, Korkut Y. Nesfatin-1 and its effects on different systems. Hippokratia. 2015;4–10.
  10. Oh-I S, Shimizu H, Satoh T, Okada S, Adachi S, Inoue K, et al. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature. 2006; 443(7112):709–12.
  11. Kim SH, Ahn MB, Cho WK, Cho KS, Jung MH, Suh BK. The relation of
  12. serum nesfatin-1 level with anthropometric and metabolic parameters in
  13. children and adolescents: A prospective observational study. Medicine
  14. (Baltimore). 2019;98(19):15460.
  15. Kelesidis T, Kelesidis I, Chou S, Mantzoros CS. Narrative review: The role of leptin in human physiology: Emerging clinical applications. Ann Intern Med. 2010;152(2):93–100.
  16. Najam SS, Awan FR, Islam M, Khurshid M, Khan AR, Siddique E, et al. Leptin Correlation with Obesity, Diabetes and Gender in a Population from Faisalabad, Pakistan. Arch Med. 2016;8(5):1–5.
  17. Higgins T. HbA1c - An analyte of increasing importance. Clin Biochem. 2012;45(13–14):1038–45.
  18. Sisodia RK, Chouhan M. The study of correlation between Body Mass Index and glycemic control-HbA1c in diabetes type 2 patients. Int J Adv Med. 2019;6(6):1788.
  19. Mellergård E, Johnsson P, Eek F. Sociodemographic factors associated with HbA1c variability in type 2 diabetes: a prospective exploratory cohort study. BMC Endocr Disord. 2020;20(1):1–8.
  20. Xu D, Yu Y, Xu Y, Ge J. Plasma nesfatin-1: Potential predictor and diagnostic biomarker for cognitive dysfunction in T2DM patient. Diabetes, Metab Syndr Obes Targets Ther. 2021;14(August):3555–66.
  21. Korani MA, Sonbol A. The relation between plasma levels of nesfatin-1 and different grades of diabetic kidney disease in patients with type 2 diabetes. Egypt J Intern Med. 2018;30(2):68–71.
  22. Wu R, Chen Z, Xu Y, Ge J, Lü X. Change in plasma nesfatin-1 concentration within high-fat diet induced nonalcoholic fatty liver disease rat models. Wei Sheng Yan Jiu. 2016 May;45(3):452–7
  23. Vinitha R, Ram J, Snehalatha C, Nanditha A, Shetty AS, Arun R, et al. Adiponectin, leptin, interleukin-6 and HbA1c in the prediction of incident type 2 diabetes: A nested case-control study in Asian Indian men with impaired glucose tolerance. Diabetes Res Clin Pract.
  24. ;109(2):340–6.
  25. Taghdir M, Djazayeri A, Djalali M, Eshraghian M, Rajab A, Yegane HS. Relationships of serum leptin concentration with insulin, glucose, hba1c levels and insulin resistance in overweight post-menopausal diabetic women. ARYA Atheroscler J. 2010;5(4):175–80.

How to Cite

Limijadi, E. K. S., Nyoman Suci Widyastiti, Meita Hendrianingtyas, & Banundari Rachmawati. (2023). Association of appetite hormone levels with HbA1c in obese type-2 diabetes mellitus patients. Bali Medical Journal, 12(1), 729–732. https://doi.org/10.15562/bmj.v12i1.4134

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Edward Kurnia Setiawan Limijadi
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Nyoman Suci Widyastiti
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Meita Hendrianingtyas
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Banundari Rachmawati
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