Introduction: Coriandrum sativum L (ketumbar seeds) nano extract was prepared using chitosan as a nano extract framework and tripolyphosphate as a stabilizer by ionic gelatin method. This study aimed to reduce free radicals in streptozotocin-induced hyperglycaemic rats by administering Coriandrum sativum L nano extract as nano herbal
Methods: The surface topography of nano extract and characterization of zeta potential particle size was carried out using PSA (Particle Size Analyser). The ability of nano extract as anti-hyperglycaemic on streptozotocin-induced rats was tested using the randomized post-test only control group design.
Results: The result of the antihyperglycemic test on streptozotocin-induced rats showed that oral administration of the nano extract at a dose of 50 mg/Kg BW/day gave the best result for decreasing glucose blood, and MDA and increasing SOD levels in hyperglycaemic rats. The characterization of nano extract using PSA showed change here had been an encapsulation of bioactive substances from Coriandrum sativum L extract on the chitosan-tripolyphosphate absorption of NH, PO groups, and change histopathology pancreas of hyperglycaemic wistar rats. Characterization with PSA strongly supports nano extract as a delivery system for bioactive substances with a zeta potential of -25.80 mV and a particle size of 455.20 nm.
Conclusion: Coriandrum sativum L (ketumbar seeds) nano extract was prepared using chitosan had potential to reduce free radicals in streptozotocin-induced hyperglycaemic rats.