CYP1A1 rs464903 increased the risk of undifferentiated type nasopharyngeal carcinoma among the Balinese population

I Gde Ardika Nuaba; I Wayan Weta; Wayan Suardana; Desak Made Wihandani; I Gede Putu Supadmanaba; Ni Nyoman Shinta Prasista Sari

doi:10.15562/bmj.v12i1.4120

CYP1A1 rs464903 increased the risk of undifferentiated type nasopharyngeal carcinoma among the Balinese population

I Gde Ardika Nuaba ,

I Wayan Weta ,

Wayan Suardana ,

Desak Made Wihandani ,

I Gede Putu Supadmanaba ,

Ni Nyoman Shinta Prasista Sari ,

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DOI: https://doi.org/10.15562/bmj.v12i1.4120 |
Published: 2023-02-03

Abstract

Introduction: Nasopharyngeal carcinoma is a tumor that arises from epithelial cells covering the surface of the nasopharynx. In terms of malignancy, NPC is number 1 in the OHNS and number 5 in Indonesia. Certain risk factors that can predispose an individual to NPC include an EBV infection, salted fish consumption, and smoking. Previous studies also show that the polymorphism of CYP1A1 rs4646903 affect the risk factor and mechanism of NPC incidence.

Methods: This is a case-control study conducted at Prof. dr. I.G.N.G. Ngoerah General Hospital, Denpasar. The study used 62 samples. The sample then underwent DNA isolation and amplification using PCR and afterward, visualization, DNA sequencing, and analysis.

Results: Bivariate analysis shows that CYP1A1 have a significant relationship with NPC incidence with a p-value of 0.007 (OR: 1.48 ; 95% CI 4.87 (1.5-15.9)).

Conclusions: The polymorphisms of CYP1A1 rs4646903 is proven to be the risk factors in the mechanism of undifferentiated NPC among the Balinese population.

References

Sung H, Ferlay J, Siegel RL, Laversanne, M Soerjomataram, I Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–249.
Adham M, Kurniawan A, Muhtadi A, Roezin A, Hermani B, Gondhowiardjo S, et al. Nasopharyngeal Carcinoma in Indonesia: Epidemiology, Incidence, Signs, and Symptoms at Presentation. Chin J Cancer. 2012;31(4):185–9.
Pratiwi da AC, Nuaba IGA. Characteristic of nasopharyngeal carcinoma patients in Sanglah General Hospital Denpasar period 2016-2020. GSC Adv Res Rev. 2022;10(3):131–5.
Djufri N, Pieter N. Epidemiologi. In: Karsinoma Nasofaring. 2020.
Shahriary GM, Galehdari H, Jalali A, Zanganeh F, Alavi SMR, Aghanoori MR. CYP2E1*5B, CYP2E1*6, CYP2E1*7B, CYP2E1*2, and CYP2E1*3 allele frequencies in iranian populations. Asian Pacific J Cancer Prev. 2012;13(12):6505–10.
Farhat F, Sari MI, Chrestella J, Syari RP. The genetic variant of GSTP1 and immune response of immunoglobulin A (IgA) on nasopharyngeal carcinoma patients. IOP Conf Ser Earth Environ Sci. 2021;713(1).
Türker G. Cytochrome P450 1A1. In: Handbook of Fertility: Nutrition, Diet, Lifestyle and Reproductive Health. Elsevier Inc.; 2015. p. 45–59.
Shinde S, Baghel VS, DIxit AK, Dixit V, Tiwari AK, Pandey SK, et al. CYP1A1 rs4646903 T> C and rs1048943 A> G polymorphisms and the risk of colorectal cancer: An updated meta-analysis. Polymorphism. 2021;7:1–12.
Hashibe M, Brennan P, Strange RC, Bhisey R, Cascorbi I, Lazarus P, Oude Ophuis MB, Benhamou S, Foulkes WD, Katoh T, Coutelle C, Romkes M, Gaspari L, Taioli E BP. Meta- and pooled analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes and risk of head and neck cancer. Cancer Epidemiol Biomarkers Prev. 2003;12(12):1509–17.
Moorthy B, Chu C, Carlin DJ. Polycyclic aromatic hydrocarbons: from metabolism to lung cancer. Toxicol Sci. 2015 May;145(1):5–15.
Zhou SF, Liu JP, Chowbay B. Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metab Rev. 2009;41(2):89–295.
Ghania D, Katia B, Dalila S. Cyp1a1 Gene Polymorphism and Nasopharyngeal Carcinoma in Algerian Population. Curr Trends Nat Sci. 2020;9(18):218–25.
Singh SA, Ghosh SK. Metabolic Phase I (CYPs) and Phase II (GSTs) Gene Polymorphisms and Their Interaction with Environmental Factors in Nasopharyngeal Cancer from the Ethnic Population of Northeast India. Pathol Oncol Res. 2019;25(1):33–44.
Khlifi R, Messaoud O, Rebai A, Hamza-Chaffai A. Polymorphisms in the human cytochrome P450 and arylamine N-acetyltransferase: Susceptibility to head and neck cancers. Biomed Res Int. 2013;2013(Table 1).
Y.F.Xu, Q.H.Pan, C.Cui. Association of nasopharyngeal carcinoma risk with cytochrome P450 CYP1A1 gene polymorphisms. Chinese J Prev Med. 2009;43(7):586–90.
Lourembam DS, Singh AR, Sharma TD, Singh TS, Singh TR, Singh LS. Evaluation of Risk Factors for Nasopharyngeal Carcinoma in a High-risk Area of India, the Northeastern Region. Asian Pacific J Cancer Prev. 2015;16(12):4927–35.

[1] Sung H, Ferlay J, Siegel RL, Laversanne, M Soerjomataram, I Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–249.

[2] Adham M, Kurniawan A, Muhtadi A, Roezin A, Hermani B, Gondhowiardjo S, et al. Nasopharyngeal Carcinoma in Indonesia: Epidemiology, Incidence, Signs, and Symptoms at Presentation. Chin J Cancer. 2012;31(4):185–9.

[3] Pratiwi da AC, Nuaba IGA. Characteristic of nasopharyngeal carcinoma patients in Sanglah General Hospital Denpasar period 2016-2020. GSC Adv Res Rev. 2022;10(3):131–5.

[4] Djufri N, Pieter N. Epidemiologi. In: Karsinoma Nasofaring. 2020.

[5] Shahriary GM, Galehdari H, Jalali A, Zanganeh F, Alavi SMR, Aghanoori MR. CYP2E1*5B, CYP2E1*6, CYP2E1*7B, CYP2E1*2, and CYP2E1*3 allele frequencies in iranian populations. Asian Pacific J Cancer Prev. 2012;13(12):6505–10.

[6] Farhat F, Sari MI, Chrestella J, Syari RP. The genetic variant of GSTP1 and immune response of immunoglobulin A (IgA) on nasopharyngeal carcinoma patients. IOP Conf Ser Earth Environ Sci. 2021;713(1).

[7] Türker G. Cytochrome P450 1A1. In: Handbook of Fertility: Nutrition, Diet, Lifestyle and Reproductive Health. Elsevier Inc.; 2015. p. 45–59.

[8] Shinde S, Baghel VS, DIxit AK, Dixit V, Tiwari AK, Pandey SK, et al. CYP1A1 rs4646903 T> C and rs1048943 A> G polymorphisms and the risk of colorectal cancer: An updated meta-analysis. Polymorphism. 2021;7:1–12.

[9] Hashibe M, Brennan P, Strange RC, Bhisey R, Cascorbi I, Lazarus P, Oude Ophuis MB, Benhamou S, Foulkes WD, Katoh T, Coutelle C, Romkes M, Gaspari L, Taioli E BP. Meta- and pooled analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes and risk of head and neck cancer. Cancer Epidemiol Biomarkers Prev. 2003;12(12):1509–17.

[10] Moorthy B, Chu C, Carlin DJ. Polycyclic aromatic hydrocarbons: from metabolism to lung cancer. Toxicol Sci. 2015 May;145(1):5–15.

[11] Zhou SF, Liu JP, Chowbay B. Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metab Rev. 2009;41(2):89–295.

[12] Ghania D, Katia B, Dalila S. Cyp1a1 Gene Polymorphism and Nasopharyngeal Carcinoma in Algerian Population. Curr Trends Nat Sci. 2020;9(18):218–25.

[13] Singh SA, Ghosh SK. Metabolic Phase I (CYPs) and Phase II (GSTs) Gene Polymorphisms and Their Interaction with Environmental Factors in Nasopharyngeal Cancer from the Ethnic Population of Northeast India. Pathol Oncol Res. 2019;25(1):33–44.

[14] Khlifi R, Messaoud O, Rebai A, Hamza-Chaffai A. Polymorphisms in the human cytochrome P450 and arylamine N-acetyltransferase: Susceptibility to head and neck cancers. Biomed Res Int. 2013;2013(Table 1).

[15] Y.F.Xu, Q.H.Pan, C.Cui. Association of nasopharyngeal carcinoma risk with cytochrome P450 CYP1A1 gene polymorphisms. Chinese J Prev Med. 2009;43(7):586–90.

[16] Lourembam DS, Singh AR, Sharma TD, Singh TS, Singh TR, Singh LS. Evaluation of Risk Factors for Nasopharyngeal Carcinoma in a High-risk Area of India, the Northeastern Region. Asian Pacific J Cancer Prev. 2015;16(12):4927–35.

CYP1A1 rs464903 increased the risk of undifferentiated type nasopharyngeal carcinoma among the Balinese population

Abstract

References

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