Skip to main content Skip to main navigation menu Skip to site footer

Relationship between Vitamin D Levels and Platelet Function in the Elderly Patients with Coronary Heart Disease

  • Charles Limantoro ,
  • Catharina Suharti ,
  • Trilaksana Nugroho ,
  • Friska Wilda Wijaya ,

Abstract

Introduction: Coronary Heart Disease (CHD) is a degenerative disease caused by fat accumulation and chronic inflammation. The elderly have a significant CHD risk due to the prevalence of vitamin D insufficiency and decreased platelet function, influencing the inflammatory response in this population. Therefore, this study aims to assess the relationship between vitamin D levels and platelet function measured by the mean platelet volume (MPV) and P-Selectin serum levels of CHD patients.

Method: The cross-sectional design was carried out on stable CHD patients aged 60-75. Meanwhile, vitamin D, MPV, and P-Selectin were taken through venous blood, and an ELISA examination was performed to determine their levels in serum. A correlation test using the Pearson product-moment was also conducted between vitamin D and platelet function.

Result: The subjects involved were 45 male and 16 female at 73.8% and 23.2%, respectively. The highest risk factor was dyslipidemia found in 45 (73.8%) and all subjects (100%) received statins. This study showed no correlation between vitamin D levels and MPV levels (p= 0.094) and P-Selectin (p=0.362).

Conclusion: Vitamin D levels are not associated with platelet function levels (MPV and P-Selectin) in elderly patients with CHD.

References

  1. World Health Organization. World Population Ageing 2019 Highlights [Internet]. UN; 2019. Available from: http://dx.doi.org/10.18356/9df3caed-en
  2. Global Status Report on Noncommunicable Disease 2014 (Internet). Geneva: World Heal Organ. 2014;
  3. Saidi A, Welt FGP. Arterial Disease—Atherosclerosis. In: SCAI Interventional Cardiology Review. 3rd ed. Wolters Kluwer; 2018. p. 28–51.
  4. Malekmohammad K, Bezsonov EE, Rafieian-Kopaei M. Role of lipid accumulation and inflammation in atherosclerosis: Focus on molecular and cellular mechanisms. Front Cardiovasc Med. 2021;8.
  5. Vakhtangadze T, Tak RS, Singh U, Baig MS, Bezsonov E. Gender differences in atherosclerotic vascular disease: From lipids to clinical outcomes. Front Cardiovasc Med. 2021;8:637.
  6. Brown JC, Gerhardt TE, Kwon E. Risk Factors For Coronary Artery Disease. Risk Factors Coron Artery Dis. 2022 Jun;1–219.
  7. Fioranelli M, Bottaccioli AG, Bottaccioli F, Bianchi M, Rovesti M, Roccia MG. Stress and inflammation in coronary artery disease: A review psychoneuroendocrineimmunology-based. Front Immunol. 2018 Sep;9(SEP):2031.
  8. Tomaiuolo M, Brass LF, Stalker TJ. Regulation of Platelet Activation and Coagulation and Its Role in Vascular Injury and Arterial Thrombosis. Interv Cardiol Clin. 2017 Jan;6(1):1–12.
  9. Blann AD, Nadar SK, Lip GYH. The adhesion molecule P-selectin and cardiovascular disease. Eur Heart J. 2003;24(24):2166–79.
  10. Xu M, He XY, Huang P. The Relationship between the Mean Platelet Volume and Carotid Atherosclerosis and Prognosis in Patients with Acute Cerebral Infarction. Biomed Res Int. 2020;2020.
  11. Slavka G, Perkmann T, Haslacher H, Greisenegger S, Marsik C, Wagner OF, et al. Mean Platelet Volume May Represent a Predictive Parameter for Overall Vascular Mortality and Ischemic Heart Disease. Arterioscler Thromb Vasc Biol. 2011 May;31(5):1215–8.
  12. Di Rosa M, Malaguarnera G, De Gregorio C, Palumbo M, Nunnari G, Malaguarnera L. Immuno-modulatory effects of vitamin D3 in human monocyte and macrophages. Cell Immunol. 2012;280(1):36–43.
  13. Schleithoff SS, Zittermann A, Tenderich G, Berthold HK, Stehle P, Koerfer R. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr. 2006 Apr;83(4):754–9.
  14. Murat SN, Duran M, Kalay N, Gunebakmaz O, Akpek M, Doger C, et al. Relation between mean platelet volume and severity of atherosclerosis in patients with acute coronary syndromes. Angiology. 2013 Feb;64(2):131–6.
  15. Kucukay MB, Alanli R. Vitamin D Replacement Effect on Platelet Counts. J Coll Physicians Surg Pak. 2021 Sep;31(9):1064–8.
  16. Alharbi A.

    A Potential Role of Vitamin D on Platelet Leukocyte Aggregation and Pathological Events in Sepsis: An Updated Review

    . J Inflamm Res. 2021 Jul;14:3651–64.
  17. WHO. World Population Ageing 2019. 2019.
  18. Kupisz-Urbańska M, Łukaszkiewicz J, Marcinowska-Suchowierska E. Vitamin D in Elderly. Vitam D. 2021 May;
  19. Korniluk A, Koper-Lenkiewicz OM, Kamińska J, Kemona H, Dymicka-Piekarska V. Mean platelet volume (MPV): New perspectives for an old marker in the course and prognosis of inflammatory conditions. Mediators Inflamm. 2019;2019:1–15.
  20. Gawaz M, Langer H, May A. Platelets in inflamation and atherogenesis. J Clin Invest. 2005;115:12.
  21. Verdoia M, Schaffer A, Sartori C, Barbieri L, Cassetti E, Marino P, et al. Vitamin D deficiency is independently associated with the extent of coronary artery disease. Eur J Clin Invest. 2014 Jul;44(7):634–42.
  22. Cure E, Balik MS, Cumhur Cure M, Guvercin Y, Erkut A, Yuce S, et al. Is the mean platelet volume predictive of hip fractures in the elderly? Ann Lab Med. 2013/08/08. 2013 Sep;33(5):367–70.
  23. Cumhur Cure M, Cure E, Yuce S, Yazici T, Karakoyun I, Efe H. Mean platelet volume and vitamin D level. Ann Lab Med. 2014/02/13. 2014 Mar;34(2):98–103.
  24. Park YC, Kim J, Seo MS, Hong SW, Cho ES, Kim JK. Inverse relationship between vitamin D levels and platelet indices in Korean adults. Hematology. 2017 Dec;22(10):623–9.
  25. Lindqvist PG, Epstein E, Olsson H. Does an active sun exposure habit lower the risk of venous thrombotic events? A D-lightful hypothesis. J Thromb Haemost. 2009;7(4):605–10.
  26. Hejazi ME, Modarresi-Ghazani F, Hamishehkar H, Mesgari-Abbasi M, Dousti S, Entezari-Maleki T. The Effect of Treatment of Vitamin D Deficiency on the Level of P-Selectin and hs-CRP in Patients With Thromboembolism: A Pilot Randomized Clinical Trial. J Clin Pharmacol. 2017 Jan;57(1):40–7.

How to Cite

Limantoro, C., Catharina Suharti, Trilaksana Nugroho, & Friska Wilda Wijaya. (2022). Relationship between Vitamin D Levels and Platelet Function in the Elderly Patients with Coronary Heart Disease. Bali Medical Journal, 11(3), 1594–1597. https://doi.org/10.15562/bmj.v11i3.3911

HTML
0

Total
2

Share

Search Panel

Charles Limantoro
Google Scholar
Pubmed
BMJ Journal


Catharina Suharti
Google Scholar
Pubmed
BMJ Journal


Trilaksana Nugroho
Google Scholar
Pubmed
BMJ Journal


Friska Wilda Wijaya
Google Scholar
Pubmed
BMJ Journal