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The effect of free peritoneal patch on fibroblast count and density of collagen on primary colon anastomosis in intraperitoneal infection in New Zealand White Rabbit model

  • Adya Jati Nugrahadi ,
  • Fendy Matulatan ,
  • I Gusti Bagus Adria Hariastawa ,


Abstract

Background: In intraperitoneal infection or peritonitis, intestinal resection and anastomosis might result in severe morbidity and intestinal anastomosis leakage have been documented to be fatal. We aim to examined the effect of free peritoneal patch on fibroblast count and density of collagen on primary colon anastomosis in intraperitoneal infection.

Methods: This is an experimental study with randomized control trial design using New Zealand White Rabbit. We collected sample’s characteristic data (e.g., age, weight before and after intervention), fibroblast and collagen levels.

Results: The mean of fibroblast level in treatment group was higher than the mean of fibroblast level in control group but there was no significant difference between both group (P value=0.202). The medial collagen level in treatment group was 2, higher than the medial collagen level in control group that was 1 and there was significant difference between both group (P value = 0.010)

Conclusion: The free peritoneal patch on colon anastomosis in intraperitoneal infection can increase fibroblasts and collagen levels compared to those without free peritoneal patch.

Keywords: free peritoneal patch fibroblast count collagen density primary colon anastomosis intraperitoneal infection

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How to Cite

Nugrahadi, A. J., Matulatan, F. ., & Hariastawa, I. G. B. A. (2022). The effect of free peritoneal patch on fibroblast count and density of collagen on primary colon anastomosis in intraperitoneal infection in New Zealand White Rabbit model. Bali Medical Journal, 11(3), 2066–2070. https://doi.org/10.15562/bmj.v11i3.3886
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Adya Jati Nugrahadi
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Fendy Matulatan
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I Gusti Bagus Adria Hariastawa
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