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Abstract

Obesity is a health problem that has become globally significant in recent decades. Obesity is often associated with low-grade chronic inflammation. This review aims to describe the relationship of inflammation in obesity. The method used is descriptive qualitative by conducting a literature review related to inflammation and obesity. The study's results indicate that inflammation is related to obesity and has an important role. Inflammation is a manifestation of increased oxidative stress. This usually occurs in individuals who are obese.

Keywords: inflammation obesity mechanism

References

  1. Fruh SM. Obesity: Risk factors, complications, and strategies for sustainable long-term weight management. J Am Assoc Nurse Pract. 2017 Oct;29(S1):S3-S14. doi: 10.1002/2327-6924.12510. PMID: 29024553; PMCID: PMC6088226.
  2. Svalastog AL, Donev D, Jahren Kristoffersen N, Gajović S. Concepts and definitions of health and health-related values in the knowledge landscapes of the digital society. Croat Med J. 2017 Dec 31;58(6):431-435. doi: 10.3325/cmj.2017.58.431. PMID: 29308835; PMCID: PMC5778676.
  3. McCartney G, Popham F, McMaster R, Cumbers A. Defining health and health inequalities. Public Health. 2019 Jul;172:22-30. doi: 10.1016/j.puhe.2019.03.023. Epub 2019 May 31. PMID: 31154234; PMCID: PMC6558275.
  4. Djalalinia S, Qorbani M, Peykari N, Kelishadi R. Health impacts of Obesity. Pak J Med Sci. 2015 Jan-Feb;31(1):239-42. doi: 10.12669/pjms.311.7033. PMID: 25878654; PMCID: PMC4386197.
  5. Alice A, Yadav M, Verma R, Kumari M, Arora S. Effect of obesity on balance: A literature review. International Journal of Health Sciences. 2022;6(S4):3261-3279. DOI: https://doi.org/10.53730/ijhs.v6nS4.9126.
  6. Gaesser GA, Angadi SS. Obesity treatment: Weight loss versus increasing fitness and physical activity for reducing health risks. iScience. 2021 Sep 20;24(10):102995. doi: 10.1016/j.isci.2021.102995. PMID: 34755078; PMCID: PMC8560549.
  7. Singer BJ, Thompson RN, Bonsall MB. The effect of the definition of ‘pandemic’ on quantitative assessments of infectious disease outbreak risk. Scientific Reports. 2021;11 (2547):1-12. DOI: https://doi.org/10.1038/s41598-021-81814-3.
  8. Hruby A, Hu FB. The Epidemiology of Obesity: A Big Picture. Pharmacoeconomics. 2015 Jul;33(7):673-89. doi: 10.1007/s40273-014-0243-x. PMID: 25471927; PMCID: PMC4859313.
  9. Jackson SE, Llewellyn CH, Smith L. The obesity epidemic – Nature via nurture: A narrative review of high-income countries. SAGE Open Medicine. 2020;8:12-19. DOI: https://doi.org/10.1177/2050312120918265.
  10. Lin X, Li H. Obesity: Epidemiology, Pathophysiology, and Therapeutics. Front Endocrinol (Lausanne). 2021 Sep 6;12:706978. doi: 10.3389/fendo.2021.706978. PMID: 34552557; PMCID: PMC8450866.
  11. Mulyani WRW, Sanjiwani MID, Sandra, Prabawa IPY, Lestari AAW, Wihandani DM, Suastika K, Saraswati MR, Bhargah A, Manuaba IBAP. Chaperone-Based Therapeutic Target Innovation: Heat Shock Protein 70 (HSP70) for Type 2 Diabetes Mellitus. Diabetes Metab Syndr Obes. 2020;13:559-568. DOI: 10.2147/DMSO.S232133.
  12. Artha IMJR, Bhargah A, Dharmawan NK, Pande UW, Triyana KA, Mahariski PA, Yuwono J, Bhargah V, Prabawa IPY, Manuaba IBAP, Rina IK. High level of individual lipid profile and lipid ratio as a predictive marker of poor glycemic control in type-2 diabetes mellitus. Vasc Health Risk Manag. 2019;15:149-157. doi: 10.2147/VHRM.S209830.
  13. Gamayanti K. Ayu V, Ratnasari NLMN, Bhargah A. The pattern of insulin use in patients with type 2 diabetes mellitus in the internal medicine clinic of the Negara General Hospital for the period July – August 2018. Intisari Sains Medis. 2018;9(3)68-73. https://doi.org/10.15562/ism.v9i3.306
  14. Longo M, Zatterale F, Naderi J, Parrillo L, Formisano P, Raciti GA, Beguinot F, Miele C. Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications. Int J Mol Sci. 2019 May 13;20(9):2358. doi: 10.3390/ijms20092358. PMID: 31085992; PMCID: PMC6539070.
  15. Vegiopoulos A, Rohm M, Herzig S. Adipose tissue: between the extremes. EMBO J. 2017 Jul 14;36(14):1999-2017. doi: 10.15252/embj.201696206. Epub 2017 Jun 16. PMID: 28623240; PMCID: PMC5509999.
  16. Morgan-Bathke ME, Jensen MD. Preliminary evidence for reduced adipose tissue inflammation in vegetarians compared with omnivores. Nutrition Journal. 2019;18(45):12-19. DOI: https://doi.org/10.1186/s12937-019-0470-2.
  17. Parra-Peralbo E, Talamillo A, Barrio R. Origin and Development of the Adipose Tissue, a Key Organ in Physiology and Disease. Front Cell Dev Biol. 2021 Dec 21;9:786129. doi: 10.3389/fcell.2021.786129. PMID: 34993199; PMCID: PMC8724577.
  18. Kusminski CM, Scherer PE. Mitochondrial dysfunction in white adipose tissue. Trends Endocrinol Metab. 2012 Sep;23(9):435-43. doi: 10.1016/j.tem.2012.06.004. Epub 2012 Jul 10. PMID: 22784416; PMCID: PMC3430798.
  19. Zhou WBS, Meng J, Zhang J. Does Low Grade Systemic Inflammation Have a Role in Chronic Pain? Front Mol Neurosci. 2021 Nov 10;14:785214. doi: 10.3389/fnmol.2021.785214. PMID: 34858140; PMCID: PMC8631544.
  20. Minihane AM, Vinoy S, Russell WR, Baka A, Roche HM, Tuohy KM, Teeling JL, Blaak EE, Fenech M, Vauzour D, McArdle HJ, Kremer BH, Sterkman L, Vafeiadou K, Benedetti MM, Williams CM, Calder PC. Low-grade inflammation, diet composition and health: current research evidence and its translation. Br J Nutr. 2015 Oct 14;114(7):999-1012. doi: 10.1017/S0007114515002093. Epub 2015 Jul 31. PMID: 26228057; PMCID: PMC4579563.
  21. Ayyadurai VAS, Deonikar P, Bannuru RR. Attenuation of low-grade chronic inflammation by phytonutrients: A computational systems biology analysis. Clin Nutr ESPEN. 2022 Jun;49:425-435. doi: 10.1016/j.clnesp.2022.03.010. Epub 2022 Mar 31. PMID: 35623848.
  22. Dignass A, Farrag K, Stein J. Limitations of Serum Ferritin in Diagnosing Iron Deficiency in Inflammatory Conditions. Int J Chronic Dis. 2018 Mar 18;2018:9394060. doi: 10.1155/2018/9394060. PMID: 29744352; PMCID: PMC5878890.
  23. Peng YY, Uprichard J. Ferritin and iron studies in anaemia and chronic disease . Annals of Clinial Biochemistry: International Journal of Laboratory Medicine. 2016;54(1):43-48. DOI: https://doi.org/10.1177/0004563216675185.
  24. Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2017 Dec 14;9(6):7204-7218. doi: 10.18632/oncotarget.23208. PMID: 29467962; PMCID: PMC5805548.
  25. Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, Ferrucci L, Gilroy DW, Fasano A, Miller GW, Miller AH, Mantovani A, Weyand CM, Barzilai N, Goronzy JJ, Rando TA, Effros RB, Lucia A, Kleinstreuer N, Slavich GM. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019 Dec;25(12):1822-1832. doi: 10.1038/s41591-019-0675-0. Epub 2019 Dec 5. PMID: 31806905; PMCID: PMC7147972.
  26. Gallo J, Raska M, Kriegova E, Goodman SB. Inflammation and its resolution and the musculoskeletal system. Journal of Orthopaedic Translation. 2017;10(2):52-67. DOI: https://doi.org/10.1016/j.jot.2017.05.007.
  27. Bondy SC, Wu M, Prasad KN. Attenuation of acute and chronic inflammation using compounds derived from plants. Experimental Biology and Medicine. 2020;246(4):406-413. DOI: https://doi.org/10.1177/1535370220960690.
  28. Ellulu MS, Patimah I, Khaza'ai H, Rahmat A, Abed Y. Obesity and inflammation: the linking mechanism and the complications. Arch Med Sci. 2017 Jun;13(4):851-863. doi: 10.5114/aoms.2016.58928. Epub 2016 Mar 31. PMID: 28721154; PMCID: PMC5507106.
  29. Monteiro R, Azevedo I. Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm. 2010;2010:289645. doi: 10.1155/2010/289645. Epub 2010 Jul 14. PMID: 20706689; PMCID: PMC2913796.
  30. Wu H, Ballantyne CM. Metabolic Inflammation and Insulin Resistance in Obesity. Circ Res. 2020 May 22;126(11):1549-1564. doi: 10.1161/CIRCRESAHA.119.315896. Epub 2020 May 21. PMID: 32437299; PMCID: PMC7250139.
  31. Gálvez I, Navarro MC, Martín-Cordero L, Otero E, Hinchado MD, Ortega E. The Influence of Obesity and Weight Loss on the Bioregulation of Innate/Inflammatory Responses: Macrophages and Immunometabolism. Nutrients. 2022 Jan 30;14(3):612. doi: 10.3390/nu14030612. PMID: 35276970; PMCID: PMC8840693.
  32. Han MS, White A, Perry RJ, Camporez JP, Hidalgo J, Shulman GI, Davis RJ. Regulation of adipose tissue inflammation by interleukin 6. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2751-2760. doi: 10.1073/pnas.1920004117. Epub 2020 Jan 24. PMID: 31980524; PMCID: PMC7022151.
  33. Battineni G, Sagaro GG, Chintalapudi N, Amenta F, Tomassoni D, Tayebati SK. Impact of Obesity-Induced Inflammation on Cardiovascular Diseases (CVD). Int J Mol Sci. 2021 Apr 30;22(9):4798. doi: 10.3390/ijms22094798. PMID: 33946540; PMCID: PMC8125716.
  34. Ansari S, Haboubi H, Haboubi N. Adult obesity complications: challenges and clinical impact . Therapeutic Advances in Endocrinology and Metabolism. 2020;11(2):19-28. DOI: https://doi.org/10.1177/2042018820934955.
  35. Nammi S, Koka S, Chinnala KM, Boini KM. Obesity: An overview on its current perspectives and treatment options. Nutrition Journal. 2004;3(3):14-21. DOI: https://doi.org/10.1186/1475-2891-3-3.
  36. Dragon-Durey MA, Chen X, Kirilovsky A, Ben Hamouda N, El Sissy C, Russick J, Charpentier E, Binois Y, Marliot F, Meylan M, Granier C, Pere H, Saldmann A, Rance B, Jannot AS, Baron S, Chebbi M, Fayol A, Josseaume N, Rives-Lange C, Tharaux PL, Cholley B, Diehl JL, Arlet JB, Azizi M, Karras A, Czernichow S, Smadja DM, Hulot JS, Cremer I, Tartour E, Mousseaux E, Pagès F. Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity. PLoS One. 2021 May 26;16(5):e0252026. doi: 10.1371/journal.pone.0252026. PMID: 34038475; PMCID: PMC8153504.
  37. Calder PC, Ahluwalia N, Brouns F, Buetler T, Clement K, Cunningham K, Esposito K, Jönsson LS, Kolb H, Lansink M, Marcos A, Margioris A, Matusheski N, Nordmann H, O'Brien J, Pugliese G, Rizkalla S, Schalkwijk C, Tuomilehto J, Wärnberg J, Watzl B, Winklhofer-Roob BM. Dietary factors and low-grade inflammation in relation to overweight and obesity. Br J Nutr. 2011 Dec;106 Suppl 3:S5-78. doi: 10.1017/S0007114511005460. PMID: 22133051.
  38. Oliveira TMS, Bressan J, Pimenta AM, Martínez-González MÁ, Shivappa N, Hébert JR, Hermsdorff HHM. Dietary inflammatory index and prevalence of overweight and obesity in Brazilian graduates from the Cohort of Universities of Minas Gerais (CUME project). Nutrition. 2020 Mar;71:110635. doi: 10.1016/j.nut.2019.110635. Epub 2019 Nov 1. PMID: 31881508.
  39. Vahid F, Bourbour F, Gholamalizadeh M, Shivappa N, Hébert JR, Babakhani K, Mosavi Jarrahi A, Mirzaei Dahka S, Doaei S. A pro-inflammatory diet increases the likelihood of obesity and overweight in adolescent boys: a case-control study. Diabetol Metab Syndr. 2020 Apr 7;12:29. doi: 10.1186/s13098-020-00536-0. PMID: 32292493; PMCID: PMC7140561.

How to Cite

Saturti, T. I. A. (2022). Inflammation in obesity: a review. Bali Medical Journal, 11(3), 1935–1938. https://doi.org/10.15562/bmj.v11i3.3850
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