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Relationship between knowledge and medication adherence among patients with tuberculosis: a cross-sectional survey

  • Muhammad Thesa Ghozali ,
  • Cica Tri Murani ,

Abstract

Background: The World Health Organization (WHO) stated that treatment adherence is one determinant of the successful management of pulmonary tuberculosis therapy. Non-adherence can result in recurrence or treatment failure. Knowledge of tuberculosis is crucial for a patient's adherence to treatment, and the level is proportional to the information obtained. This study aimed to determine the relationship between the knowledge level of pulmonary tuberculosis and adherence to anti-tuberculosis drugs (ATD).

Methods: This study is a non-experimental quantitative study with analytic correlation and a cross-sectional approach. Sampling was done at the Umbulharjo 1 Public Health Center, Yogyakarta, Indonesia, in November-December 2021, using purposive sampling with 43 respondents. The knowledge level and adherence were measured using a questionnaire and the Morisky Medication Adherence Scale (MMAS-8). Meanwhile, the relationship between the variables was analyzed using the Pearson Product Moment correlation test with a significance level of 95%.

Results: The results showed that respondents with high, moderate, and low knowledge levels were 88.37%, 11.63%, and 0%, respectively. Respondents with high, moderate, and low adherence to ATD were 95.34%, 4.7%, and 0%, respectively. Furthermore, analysis of the relationship to taking ATD obtained a p-value of 0.001 (<0.05) and a correlation value (r) of 0.609.

Conclusion: Most patients had high knowledge and adherence to medication, and the correlation showed a strong relationship between the variables and taking ATD.

References

  1. Du L, Chen X, Zhu X, Zhang Y, Wu R, Xu J, et al. Determinants of Medication Adherence for Pulmonary Tuberculosis Patients During Continuation Phase in Dalian, Northeast China. Patient Prefer Adherence. 2020;14:1119–28. Available from: https://pubmed.ncbi.nlm.nih.gov/32753852
  2. Fang EF, Xie C, Schenkel JA, Wu C, Long Q, Cui H, et al. A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks. Ageing Res Rev. 2020/09/21. 2020;64:101174. Available from: https://pubmed.ncbi.nlm.nih.gov/32971255
  3. Kim K, Kim B, Chung AJ, Kwon K, Choi E, Nah J. Algorithm and System for improving the medication adherence of tuberculosis patients [Internet]. 2018 International Conference on Information and Communication Technology Convergence (ICTC). IEEE; 2018. Available from: http://dx.doi.org/10.1109/ictc.2018.8539402
  4. Thi AM, Zimmerman C, Pocock NS, Chan CW, Ranganathan M. Child Domestic Work, Violence, and Health Outcomes: A Rapid Systematic Review. Int J Environ Res Public Health. 2021;19(1):427. Available from: https://pubmed.ncbi.nlm.nih.gov/35010705
  5. Watermeyer J, Penn C. Community perspectives on tuberculosis care in rural South Africa. Heal & Soc Care Community. 2018;27(1):182–90. Available from: http://dx.doi.org/10.1111/hsc.12637
  6. Liu H, Salem Y, Aggarwal S. Effects of Tai Chi on biomarkers and their implication to neurorehabilitation – a systemic review. Eur J Integr Med. 2022;50:101391. Available from: http://dx.doi.org/10.1016/j.eujim.2021.101391
  7. M'imunya JM, Kredo T, Volmink J. Patient education and counselling for promoting adherence to treatment for tuberculosis. Cochrane database Syst Rev. 2012;2012(5):CD006591–CD006591. Available from: https://pubmed.ncbi.nlm.nih.gov/22592714
  8. Sahile Z, Yared A, Kaba M. Patients' experiences and perceptions on associates of TB treatment adherence: a qualitative study on DOTS service in public health centers in Addis Ababa, Ethiopia. BMC Public Health. 2018;18(1):462. Available from: https://pubmed.ncbi.nlm.nih.gov/29631558
  9. Sari YS, Kamil H, Marthoenis. The patient with multi-drug resistant – Pulmonary tuberculosis adherence to treatment: A qualitative study. Enfermería Clínica. 2022;32:S58–61. Available from: http://dx.doi.org/10.1016/j.enfcli.2022.03.019
  10. Kurniawati A, Padmawati RS, Mahendradhata Y. Acceptability of mandatory tuberculosis notification among private practitioners in Yogyakarta, Indonesia. BMC Res Notes. 2019;12(1):543. Available from: https://pubmed.ncbi.nlm.nih.gov/31455388
  11. Saktiawati AMI, Subronto YW, Stienstra Y, Sumardi, Supit F, van der Werf TS. Sensitivity and specificity of routine diagnostic work-up for tuberculosis in lung clinics in Yogyakarta, Indonesia: a cohort study. BMC Public Health. 2019;19(1):363. Available from: https://pubmed.ncbi.nlm.nih.gov/30940123
  12. Soewondo W, Kusumaningrum CS, Hanafi M, Adiputri A, Hayuningrat PK. Co-existing active pulmonary tuberculosis with aspergilloma in a diabetic patient: A rare case report. Radiol case reports. 2022;17(4):1136–42. Available from: https://pubmed.ncbi.nlm.nih.gov/35169416
  13. Fournet N, Mollema L, Ruijs WL, Harmsen IA, Keck F, Durand JY, et al. Under-vaccinated groups in Europe and their beliefs, attitudes and reasons for non-vaccination; two systematic reviews. BMC Public Health. 2018;18(1):196. Available from: https://pubmed.ncbi.nlm.nih.gov/29378545
  14. Erlich JR, To EE, Liong S, Brooks R, Vlahos R, O’Leary JJ, et al. Targeting Evolutionary Conserved Oxidative Stress and Immunometabolic Pathways for the Treatment of Respiratory Infectious Diseases. Antioxid Redox Signal. 2020;32(13):993–1013. Available from: https://pubmed.ncbi.nlm.nih.gov/32008371
  15. Martinez-Perez P, Orozco-Beltrán D, Pomares-Gomez F, Hernández-Rizo JL, Borras-Gallen A, Gil-Guillen VF, et al. Validation and psychometric properties of the 8-item Morisky Medication Adherence Scale (MMAS-8) in type 2 diabetes patients in Spain. Aten primaria. 2021/01/25. 2021;53(2):101942. Available from: https://pubmed.ncbi.nlm.nih.gov/33508739
  16. Amran Y, Nasir NM, Dachlia D, Yelda F, Utomo B, Ariawan I, et al. Perceptions of Contraception and Patterns of Switching Contraceptive Methods Among Family-planning Acceptors in West Nusa Tenggara, Indonesia. J Prev Med Public Health. 2019/07/19. 2019;52(4):258–64. Available from: https://pubmed.ncbi.nlm.nih.gov/31390689
  17. Kanmani S, Logaraj M, John R, Arumai MM. Is economic burden still a problem among the patients with tuberculosis - A cost analysis: A descriptive cross-sectional study in Tamil Nadu. Indian J Tuberc. 2021; Available from: http://dx.doi.org/10.1016/j.ijtb.2021.09.006
  18. Kaaffah S, Soewondo P, Riyadina W, Renaldi FS, Sauriasari R. Adherence to Treatment and Glycemic Control in Patients with Type 2 Diabetes Mellitus: A 4-Year Follow-up PTM Bogor Cohort Study, Indonesia. Patient Prefer Adherence. 2021;15:2467–77. Available from: https://pubmed.ncbi.nlm.nih.gov/34803376
  19. Ayllón S, Alsina Á, Colomer J. Teachers' involvement and students' self-efficacy: Keys to achievement in higher education. PLoS One. 2019;14(5):e0216865–e0216865. Available from: https://pubmed.ncbi.nlm.nih.gov/31125346
  20. Tahseen S, Khanzada FM, Baloch AQ, Abbas Q, Bhutto MM, Alizai AW, et al. Extrapulmonary tuberculosis in Pakistan- A nation-wide multicenter retrospective study. PLoS One. 2020;15(4):e0232134–e0232134. Available from: https://pubmed.ncbi.nlm.nih.gov/32343714
  21. Moyo S, Ismail F, Van der Walt M, Ismail N, Mkhondo N, Dlamini S, et al. Prevalence of bacteriologically confirmed pulmonary tuberculosis in South Africa, 2017-19: a multistage, cluster-based, cross-sectional survey. Lancet Infect Dis. 2022/05/17. 2022;22(8):1172–80. Available from: https://pubmed.ncbi.nlm.nih.gov/35594897
  22. Rathnayake S, Dasanayake D, Maithreepala SD, Ekanayake R, Basnayake PL. Nurses' perspectives of taking care of patients with Coronavirus disease 2019: A phenomenological study. PLoS One. 2021;16(9):e0257064–e0257064. Available from: https://pubmed.ncbi.nlm.nih.gov/34478482
  23. Dumpeti S, Jothula KY, Naidu NK. Awareness about tuberculosis and RNTCP services among rural people in Nalgonda district, Telangana. J Fam Med Prim care. 2020;9(7):3281–7. Available from: https://pubmed.ncbi.nlm.nih.gov/33102284
  24. Orok E, Ndem E, Daniel E. Knowledge, attitude and perception of medical students on COVID-19 vaccines: A study carried out in a Nigerian University. Front public Heal. 2022;10:942283. Available from: https://pubmed.ncbi.nlm.nih.gov/36211686

How to Cite

Muhammad Thesa Ghozali, & Cica Tri Murani. (2023). Relationship between knowledge and medication adherence among patients with tuberculosis: a cross-sectional survey. Bali Medical Journal, 12(1), 158–163. https://doi.org/10.15562/bmj.v12i1.3826

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Muhammad Thesa Ghozali
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Cica Tri Murani
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