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The Effect of Beta vulgaris L. on the Malondialdehyde Levels in Male Wistar Rats Exposed to Cigarette Smoke


Introduction: Oxidative damage can be brought on by inhaling free radicals from cigarette smoke. Malondialdehyde (MDA), a byproduct of lipid peroxidation, is a biomarker for oxidative stress. Beta vulgaris L., sometimes known as beetroot, is a root vegetable with phenolic and betalain chemicals that have antioxidant qualities and can reduce oxidative stress in the body.

Determine how beetroot juice affects male Wistar rats exposed to cigarette smoke regarding their MDA levels.

Methods: 24 samples of male Wistar rats, separated into 4 groups, were utilized in this genuine experimental investigation using a posttest-only control group design. Traditional food and beverages were served to Group N. Two cigarettes were smoked each day by the cigarette smoking group, BV1, and BV2. Beta vulgaris L. juice was also administered to group BV1 at a dose of 8 ml/kg BW per day and to group BV2 at 16 ml/kg BW per day. MDA serum levels were measured using the TBARS technique after 28 days of therapy. The one-way ANOVA and the Games-Howell test were used to evaluate the data.

Result: The group control's mean MDA level was 1,539 ppm; the cigarette smoking group was 3,167 ppm; BV1's was 2,452 ppm, and BV2's was 2,0527 ppm. Between-group control and cigarette smoking group BV1 and BV2, as well as between BV1 and BV2, there were significant differences in MDA levels (p 0,05).

Conclusion: The MDA levels of the groups exposed to cigarette smoke and given beetroot juice were lower than those of the groups exposed to cigarette smoke alone, with the MDA levels of the group given a dosage of 8 ml/kg BW being lower than the group given a dose of 16 ml/kg BW.


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How to Cite

Alya Berliana Suharso, Dewi, P. K., Edward Kurnia Setiawan Limijadi, & Amallia Nuggetsiana Setyawati. (2022). The Effect of Beta vulgaris L. on the Malondialdehyde Levels in Male Wistar Rats Exposed to Cigarette Smoke. Bali Medical Journal, 11(3), 1509–1514.




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Alya Berliana Suharso
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Puspita Kusuma Dewi
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Edward Kurnia Setiawan Limijadi
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Amallia Nuggetsiana Setyawati
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