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The black cumin seeds oil with Curcuma xanthorrhiza extract preparation increases IFN-γ expression

  • Titiek Hidayati ,
  • Sunny Sun ,
  • Akrom ,


Introduction: According to empirical evidence, Curcuma xanthorrhiza (CX) and black cumin (BC) have been utilized extensively in Indonesia. The primary components of Curcuma xanthorrhiza and black cumin (CXBC) formulations are BC oil and CX extract. This study aimed to assess the influence of CXBC active compounds (polyphenols, flavonoids, and thymoquinone) on IFN-g expression in HTB-183 cells. This study aimed to determine the levels of vitamins and minerals in CXBC preparation and the potential for immunomodulatory activities.

Methods: We engaged in experimental laboratory research. Observing the expression of interferon-gamma (IFN-γ) was used to evaluate the immunomodulatory activities of the HTB-183 human large lung cancer cell line.

Results: The results demonstrated that the CXBC supplement included vitamins (A, C, and E) and minerals (potassium, calcium). CXBC preparations boosted HTB-183 cell IFN-γ expression.

Conclusion: The study's findings indicate that the CXBC formulation contains a high concentration of vitamins and minerals. CXBC formulations augment IFN-γ expression.


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How to Cite

Hidayati, T. ., Sun, S., & Akrom. (2023). The black cumin seeds oil with Curcuma xanthorrhiza extract preparation increases IFN-γ expression. Bali Medical Journal, 12(3), 2420–2423.