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Systemic Lupus Erythematosus Flare Triggered by COVID-19 Infection: A Case-Based Review

  • Maria Sarce Tio ,
  • Arundina Sanyoto ,


Abstract

Introduction: The coronavirus disease 19 (COVID-19) and autoimmune disease has been associated bidirectionally, several reports has shown COVID-19 precipitate an exacerbation of an autoimmune disease that has already stable. Recognize and treatment of flare in SLE condition with COVID-19 is challenging in this pandemic era. This review aims to report a case SLE patient who experienced severe flares after being infected with COVID-19 and review of the literature.

Case report: We presented a 27-year-old female with a history of Systemic Lupus Erythematosus (SLE) who experienced severe flares after being infected with COVID-19 and a review.

Methods and Results: A total of 72 potentially relevant citations were identified. After removing the duplicate citations, the title, and abstracts of 61 articles were evaluated and 11 relevant articles were reviewed in detail. A total of 72 potentially relevant citations were identified. After removing the duplicate citations, the title, and abstracts of 61 articles were evaluated and 11 relevant articles were included.

Conclusion: The COVID-19 pandemic is a devastating situation all over the world. SLE patient has already been in a susceptible condition as the disease progressed and continued having immunosuppressant therapy also one of the risk factors. A Flare condition can be happened during the COVID-19 Infection or after the infection is resolved. In SLE patient having COVI-19, close monitoring, high adherence to the therapy, and the health protocol are needed.

Keywords: COVID-19 Systemic Lupus Erythematosus (SLE) Flare

References

  1. Bonometti R, Sacchi MC, Stobbione P, Lauritano EC, Tamiazzo S, Marchegiani A, et al. The first case of systemic lupus erythematosus (SLE) triggered by COVID-19 infection. :3.
  2. Mathian A, Mahevas M, Rohmer J, Roumier M, Cohen-Aubart F, Amador-Borrero B, et al. Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus erythematosus under long-term treatment with hydroxychloroquine. Ann Rheum Dis. 2020 Jun;79(6):837–9.
  3. Khalid MZ, Rogers S, Fatima A, Dawe M, Singh R. A Flare of Systemic Lupus Erythematosus Disease After COVID-19 Infection: A Case of Lupus Cerebritis. Cureus [Internet]. 2021 Jul 2 [cited 2022 May 24]; Available from: https://www.cureus.com/articles/61861-a-flare-of-systemic-lupus-erythematosus-disease-after-covid-19-infection-a-case-of-lupus-cerebritis
  4. Caso F, Costa L, Ruscitti P, Navarini L, Del Puente A, Giacomelli R, et al. Could Sars-coronavirus-2 trigger autoimmune and/or autoinflammatory mechanisms in genetically predisposed subjects? Autoimmun Rev. 2020 May;19(5):102524.
  5. Gasparyan AY, Ayvazyan L, Blackmore H, Kitas GD. Writing a narrative biomedical review: considerations for authors, peer reviewers, and editors. Rheumatol Int. 2011 Nov 1;31(11):1409–17.
  6. Kondo Y, Kaneko Y, Oshige T, Fukui H, Saito S, Okayama M, et al. Exacerbation of immune thrombocytopenia triggered by COVID-19 in patients with systemic lupus erythematosus. Ann Rheum Dis. 2021 May;80(5):e77–e77.
  7. Kichloo A, Aljadah M, Albosta M, Wani F, Singh J, Solanki S. COVID-19 and Acute Lupus Pneumonitis: Diagnostic and Treatment Dilemma. J Investig Med High Impact Case Rep. 2020 Jun 5;8:2324709620933438.
  8. Raghavan S, Gonakoti S, Asemota IR, Mba B. A Case of Systemic Lupus Erythematosus Flare Triggered by Severe Coronavirus Disease 2019. J Clin Rheumatol. 2020 Sep;26(6):234–5.
  9. Hayden A, Vyas-Lahar A, Rella V, Rudinskaya A. Severe refractory thrombocytopenia in a woman positive for coronavirus disease 2019 with lupus and antiphospholipid syndrome. Lupus. 2020 Oct 1;29(11):1472–4.
  10. Alharthy A, Faqihi F, Nasim N, Noor A, Akhtar S, Balshi A, et al. COVID-19 in a patient with a flare of systemic lupus erythematosus: A rare case-report. Respir Med Case Rep. 2020 Oct 15;31:101252.
  11. Shamsi YA. A case of lupus nephritis flare-up in severe COVID-19 infection. 2021;76(5):5.
  12. Drenovska K, Shahid M, Mateeva V, Vassileva S. Case Report: Rowell Syndrome–Like Flare of Cutaneous Lupus Erythematosus Following COVID-19 Infection. Frontiers in Medicine [Internet]. 2022 [cited 2022 Sep 8];9. Available from: https://www.frontiersin.org/articles/10.3389/fmed.2022.815743
  13. Karsulovic C, Hojman LP, Seelmann DL, Wurmann PA. Diffuse Lymphadenopathy Syndrome as a Flare-Up Manifestation in Lupus and Mixed Connective Tissue Disease Following Mild COVID-19. Am J Case Rep. 2021 Sep 10;22:e932751-1-e932751-5.
  14. COVID-19 WRP. Pedoman Tatalaksana COVID-19 edisi 4 [Internet]. covid19.go.id. [cited 2022 Mar 2]. Available from: https://covid19.go.id/artikel/2022/02/03/pedoman-tatalaksana-covid-19-edisi-4
  15. Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020 Apr 7;323(13):1239–42.
  16. Clinical manifestations and diagnosis of systemic lupus erythematosus in adults - UpToDate [Internet]. [cited 2022 Sep 8]. Available from: https://www.uptodate.com/contents/clinical-manifestations-and-diagnosis-of-systemic-lupus-erythematosus-in-adults
  17. Hannah JR, D’Cruz DP. Pulmonary Complications of Systemic Lupus Erythematosus. Semin Respir Crit Care Med. 2019 Apr;40(2):227–34.
  18. Matthay RA, Schwarz MI, Petty TL, Stanford RE, Gupta RC, Sahn SA, et al. Pulmonary manifestations of systemic lupus erythematosus: review of twelve cases of acute lupus pneumonitis. Medicine (Baltimore). 1975 Sep;54(5):397–409.
  19. Agbuduwe C, Basu S. Haematological manifestations of COVID‐19: From cytopenia to coagulopathy. Eur J Haematol. 2020 Nov;105(5):540–6.
  20. Galanopoulos N, Christoforidou A, Bezirgiannidou Z. Lupus thrombocytopenia: pathogenesis and therapeutic implications. MJR. 2017 Jan 1;28(1):20–6.
  21. Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis. Clin Chim Acta. 2020 Jul;506:145–8.
  22. Zhang Y, Zeng X, Jiao Y, Li Z, Liu Q, Ye J, et al. Mechanisms involved in the development of thrombocytopenia in patients with COVID-19. Thromb Res. 2020 Sep;193:110–5.
  23. Hahn BH, McMahon M, Wilkinson A, Wallace WD, Daikh DI, FitzGerald J, et al. American College of Rheumatology Guidelines for Screening, Case Definition, Treatment and Management of Lupus Nephritis. Arthritis Care Res (Hoboken). 2012 Jun;64(6):797–808.
  24. Nadim MK, Forni LG, Mehta RL, Connor MJ, Liu KD, Ostermann M, et al. COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nat Rev Nephrol. 2020;16(12):747–64.
  25. Kazzi B, Fine D, Geetha D, Chung M, Monroy-Trujillo M, Timlin H. New-onset lupus nephritis associated with COVID-19 infection. Lupus. 2022 Jul;31(8):1007–11.
  26. He W, Liu X, Hu B, Li D, Chen L, Li Y, et al. Mechanisms of SARS-CoV-2 Infection-Induced Kidney Injury: A Literature Review. Frontiers in Cellular and Infection Microbiology [Internet]. 2022 [cited 2022 Sep 8];12. Available from: https://www.frontiersin.org/articles/10.3389/fcimb.2022.838213

How to Cite

Tio, M. S., & Sanyoto, A. (2022). Systemic Lupus Erythematosus Flare Triggered by COVID-19 Infection: A Case-Based Review. Bali Medical Journal, 11(3), 1448–1455. https://doi.org/10.15562/bmj.v11i3.3719
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Maria Sarce Tio
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Arundina Sanyoto
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