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High maternal homocysteine (Hcy) levels as a risk factor of preterm labor: a case-control study

  • Anak Agung Gede Putra Wiradnyana ,
  • Anak Agung Ngurah Jaya Kusuma ,
  • Tjokorda Gde Agung Suwardewa ,
  • Anom Suardika ,
  • Made Bagus Dwi Aryana ,
  • Nyoman Gede Budiana ,
  • Putu Doster Mahayasa ,
  • IP Popy Kusuardiyanto ,


Abstract

Background: Preterm labor is a serious perinatology problem with the consequences of increasing morbidity and mortality in neonates. Increased levels of homocysteine (Hcy) in serum have been reported to play a role in the pathogenesis of various pregnancy complications, including preterm labor. This study aimed to determine whether serum. Hcy levels are a risk factor for preterm labor.

Methods: This case-control study was conducted from January to June 2021. The case and control group included a consecutive woman with preterm and term labor. Homocysteine level was measured from maternal blood samples during labor. Maternal age, parity, and body mass index (BMI) data were also collected and compared between those two groups.

Results: A total of 30 preterm deliveries and 30 term deliveries were included in the study. The mean Hcy level in the preterm group was 17.26±6.814 mmol/L and in the term group was 9.788±4.532 mmol/L. Serum Hcy levels were classified as high (≥12.85 mmol/L) and low (<12.85 mmol/L) level. High serum Hcy level increased the risk of preterm labor by 9.118 times compared to low Hcy (p=0.001; 95% CI=2.581 – 32.211). There was no significant association between age, parity, and BMI with preterm labor (p>0.05).

Conclusion: High maternal serum Hcy level is a risk factor for preterm labor. Prospective studies with larger samples are required to confirm these results.

Keywords: Homocysteine preterm labor risk factors

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How to Cite

Wiradnyana, A. A. G. P., Kusuma, A. A. N. J., Suwardewa, T. G. A., Suardika, A., Aryana, M. B. D., Budiana, N. G., Mahayasa, P. D., & Kusuardiyanto, I. P. (2022). High maternal homocysteine (Hcy) levels as a risk factor of preterm labor: a case-control study. Bali Medical Journal, 11(3), 2057–2061. https://doi.org/10.15562/bmj.v11i3.3701
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Anak Agung Gede Putra Wiradnyana
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Anak Agung Ngurah Jaya Kusuma
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Tjokorda Gde Agung Suwardewa
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Anom Suardika
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Made Bagus Dwi Aryana
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Nyoman Gede Budiana
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Putu Doster Mahayasa
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IP Popy Kusuardiyanto
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