Objectives: Despite the fact that many studies have shown that the role of high sensitivity C-reactiveÂ protein (Hs-CRP) in inflammation diseases, the role of this molecule in severe head injury (SHI) hasÂ not been understood clearly. Severe head injury was defined as a trauma to the head frequently foundÂ in Emergency Units where some cases result in mortality. Severe head injury was defined as Glasgow
Coma Scale (GCS) score between 3 and 8. Based on this data, we felt that it was important toÂ determine the role of Hs-CRP as a predictor of SIRS in SHI patients.
Method: This was a CohortÂ prospective study about the role of serum Hs-CRP as a predictor for Systemic inflammatory responseÂ syndrome (SIRS) in SHI patients at Sanglah General Hospital, Bali-Indonesia from August 2012 toÂ February 2013. A number of 60 patients fulfilled the inclusive criteria. The data were analyzedÂ descriptively to show the characteristics of the samples and was analyzed using univariate and
multivariate analysis to determine the predictor factors for SIRS in SHI patients. A confidenceÂ interval of 95% (p < 0.05) was applied.
Results: From 60 samples collected, there were 43 malesÂ (71.7%) and 17 females (28.3%), the majority age of the samples were 20-40 years old (21 samples,Â 35%). On the first day 49 samples (81.6%) had elevated serum Hs-CRP levels. Fifty seven samplesÂ (95%) had SIRS, and only 3 samples (5%) did not have SIRS. Bivariate analysis between Hs-CRPÂ level and SIRS was significant (p = 0.001). Multivariate analysis showed that pneumonia and high
Hs-CRP serum levels were significant predictor factors for SIRS in SHI patients.
Conclusion: HighÂ serum Hs-CRP levels could be used as a reliable predictor factor for SIRS in SHI patients.