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Cervical invasion and lymphovascular space invasion as the most associated risk factors for lymph node metastases in endometrial cancer

  • Devita Kurniawati ,
  • Brahmana Askandar Tjokroprawiro ,
  • Primandono Perbowo ,


Background: Endometrial cancer is the second most common type of gynecologic malignancy. Studies on factors of lymphatic metastases are few. This study aimed to determine the clinical and pathological characteristics that can predict lymph node metastases.

Purpose: To determine the correlation of clinicopathological characteristics with LNM (Lymph Node Metastases) in Endometrial Cancer (EC).

Methods: This study used observational analysis and a cross-sectional methodology to examine medical records of endometrial cancer patients who underwent lymphadenectomy sampling surgery in 2018-2020. The risk factors are determined using multivariate analysis.

Results: The stage IB and IIIC1 patients accounted for the most (17.27%) of the 63 research participants. Only one patient (1.1%) is in stage IIIB. The rests are stage IA and IIIA, each including eight patients (8.13%), and stage II, which has twelve people (12.19% ). There were 17 patients with endometrial cancer who had lymph node metastases (27% ). The incidence of LNM is 23.2% in endometrioid types, while the incidence of metastases is 57.1% in non-endometrioid kinds. The incidence of LNM in EC was not linked with the patient's age (p=0.628), BMI (p=0.190), parity (p=0.194), or menopausal status (p=0.970). The study found no correlation between LNM and histological kinds (p=0.078), histopathological degrees (p=0.514), or myometrium invasion (p=0.134) in EC. The risk factors most linked with LNM in EC are LVSI (+) (OR = 0.10; IK 95% 0.19–0.56; p = 0.009) and cervical invasion (OR = 0.07; IK95 percent 0.008–0.64; p = 0.019) according to the results of multivariate analysis.

Conclusion: Cervical invasion and LVSI (+) are the risk factors most associated with the incidence of LNM.


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How to Cite

Devita Kurniawati, Tjokroprawiro, B. A., & Primandono Perbowo. (2022). Cervical invasion and lymphovascular space invasion as the most associated risk factors for lymph node metastases in endometrial cancer . Bali Medical Journal, 11(2), 797–802.




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Devita Kurniawati
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BMJ Journal

Brahmana Askandar Tjokroprawiro
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BMJ Journal

Primandono Perbowo
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BMJ Journal