Skip to main content Skip to main navigation menu Skip to site footer

Cervical invasion and lymphovascular space invasion as the most associated risk factors for lymph node metastases in endometrial cancer

  • Devita Kurniawati ,
  • Brahmana Askandar Tjokroprawiro ,
  • Primandono Perbowo ,

Abstract

Background: Endometrial cancer is the second most common type of gynecologic malignancy. Studies on factors of lymphatic metastases are few. This study aimed to determine the clinical and pathological characteristics that can predict lymph node metastases.

Purpose: To determine the correlation of clinicopathological characteristics with LNM (Lymph Node Metastases) in Endometrial Cancer (EC).

Methods: This study used observational analysis and a cross-sectional methodology to examine medical records of endometrial cancer patients who underwent lymphadenectomy sampling surgery in 2018-2020. The risk factors are determined using multivariate analysis.

Results: The stage IB and IIIC1 patients accounted for the most (17.27%) of the 63 research participants. Only one patient (1.1%) is in stage IIIB. The rests are stage IA and IIIA, each including eight patients (8.13%), and stage II, which has twelve people (12.19% ). There were 17 patients with endometrial cancer who had lymph node metastases (27% ). The incidence of LNM is 23.2% in endometrioid types, while the incidence of metastases is 57.1% in non-endometrioid kinds. The incidence of LNM in EC was not linked with the patient's age (p=0.628), BMI (p=0.190), parity (p=0.194), or menopausal status (p=0.970). The study found no correlation between LNM and histological kinds (p=0.078), histopathological degrees (p=0.514), or myometrium invasion (p=0.134) in EC. The risk factors most linked with LNM in EC are LVSI (+) (OR = 0.10; IK 95% 0.19–0.56; p = 0.009) and cervical invasion (OR = 0.07; IK95 percent 0.008–0.64; p = 0.019) according to the results of multivariate analysis.

Conclusion: Cervical invasion and LVSI (+) are the risk factors most associated with the incidence of LNM.

References

  1. American Cancer Society. Key statistics for endometrial cancer [Internet]. 2021. Available from: https://www.cancer.org/cancer/endometrial-cancer/about/keystatistics.html
  2. Ariyanto TB. Perbandingan Luaran Pasien Kanker Endometrium Yang Dilakukan Operasi Laparoskopi Dan Yang Dilakukan Operasi Laparotomi di RSUD Dr. Soetomo Tahun 2017. Med Heal Sci J. 2020;4(1):55–62. Available from: http://dx.doi.org/10.33086/mhsj.v4i1.1446
  3. Akhtar M, Al Hyassat S, Elaiwy O, Rashid S, Al-Nabet ADMH. Classification of Endometrial Carcinoma: New Perspectives Beyond Morphology. Adv Anat Pathol. 2019;26(6):421–7. Available from: http://dx.doi.org/10.1097/pap.0000000000000251
  4. Talhouk A, McAlpine JN. New classification of endometrial cancers: the development and potential applications of genomic-based classification in research and clinical care. Gynecol Oncol Res Pract. 2016;3:14. Available from: https://pubmed.ncbi.nlm.nih.gov/27999680
  5. Ignatov T, Eggemann H, Burger E, Ortmann O, Costa SD, Ignatov A. Ovarian metastasis in patients with endometrial cancer: risk factors and impact on survival. J Cancer Res Clin Oncol. 2018;144(6):1103–7. Available from: http://dx.doi.org/10.1007/s00432-018-2628-2
  6. Chen Q, Feng Y, Wang W, Lv W, Li B. Preoperative predictive factor analysis of ovarian malignant involvement in premenopausal patients with clinical stage I endometrioid endometrial carcinoma. Sci Rep. 2021;11(1):1219. Available from: https://pubmed.ncbi.nlm.nih.gov/33441576
  7. Jia P, Zhang Y. Ovarian preservation improves overall survival in young patients with early-stage endometrial cancer. Oncotarget. 2017;8(35):59940–9. Available from: https://pubmed.ncbi.nlm.nih.gov/28938695
  8. Sanderson PA, Critchley HOD, Williams ARW, Arends MJ, Saunders PTK. New concepts for an old problem: the diagnosis of endometrial hyperplasia. Hum Reprod Update. 2017;23(2):232–54. Available from: https://pubmed.ncbi.nlm.nih.gov/27920066
  9. Passarello K, Kurian S, Villanueva V. Endometrial Cancer: An Overview of Pathophysiology, Management, and Care. Semin Oncol Nurs. 2019;35(2):157–65. Available from: http://dx.doi.org/10.1016/j.soncn.2019.02.002
  10. Staff S, Aaltonen M, Huhtala H, Pylvänäinen K, Mecklin J-P, Mäenpää J. Endometrial cancer risk factors among Lynch syndrome women: a retrospective cohort study. Br J Cancer. 2016/06/23. 2016;115(3):375–81. Available from: https://pubmed.ncbi.nlm.nih.gov/27336600

How to Cite

Devita Kurniawati, Tjokroprawiro, B. A., & Primandono Perbowo. (2022). Cervical invasion and lymphovascular space invasion as the most associated risk factors for lymph node metastases in endometrial cancer . Bali Medical Journal, 11(2), 797–802. https://doi.org/10.15562/bmj.v11i2.3645

HTML
2

Total
20

Share

Search Panel

Devita Kurniawati
Google Scholar
Pubmed
BMJ Journal


Brahmana Askandar Tjokroprawiro
Google Scholar
Pubmed
BMJ Journal


Primandono Perbowo
Google Scholar
Pubmed
BMJ Journal