Skip to main content Skip to main navigation menu Skip to site footer

Aloe vera and its potency as antituberculosis against strains of Mycobacterium tuberculosis that is resistant to some tuberculosis drugs

  • Herin Mawarti ,
  • Mukhamad Rajin ,
  • Zulfa Khusniyah ,
  • Zulfikar Asumta ,
  • Khotimah ,
  • Christina Destri Wiwis Wijayanti ,


Introduction: Aloe vera has anti-bacterial ability against Gram-positive and Gram-negative bacteria; however, anti-bacterial study, especially in multidrug resistant strain of Mycobacterium tuberculosis, has not been evaluated yet. This study aims to determine the potential of Aloe vera as an antituberculosis against drug-resistant strains of tuberculosis.

Method: Stages of research include the production of ethanol extract of Aloe vera, then testing the phytochemicals (identification of alkaloids, steroids/triterpenoids, anthraquinone, flavonoids, saponins, tannins) and chemical content testing by thin layer chromatography (TLC). The anti-bacterial test for Mycobacterium tuberculosis was performed on the Lowenstein Jensen media.

Results: Test results showed the qualitative identification, and TLC contains alkaloids, steroids/triterpenoids, anthraquinone, flavonoids, saponins, and tannins. Antioxidant activity against DPPH radical shows an IC50 value of 6927.133 ppm. Test of anti-bacterial activity to Mycobacterium Tuberculosis H37Rv and MDR TB strains HE (resistant to INH and Ethambutol), and SR (resistant to streptomycin and Rifampicin) showed inhibition ranging concentration of 50 mg/mL in all extracts as well as to test the sensitivity, a sensitive start to a concentration of 50 mg/mL in all extracts.

Conclusions: Aloe vera contains alkaloids, steroids/triterpenoids, anthraquinone, flavonoids, saponins, and tannins that act as antioxidants and antituberculosis against strains of Mycobacterium tuberculosis that are not resistant and resistant to anti-tuberculosis drugs.


  1. WHO. Global tuberculosis report 2020: executive summary. WHO. Geneva; 2020.
  2. WHO. Tuberculosis. 2021;
  3. Migliori GB, Tiberi S, Zumla A, Petersen E, Chakaya JM, Wejse C, et al. MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network. Int J Infect Dis. 2020;92:S15–25. Available from: 10.1016/j.ijid.2020.01.042
  4. Alemu A, Bitew ZW, Worku T, Gamtesa DF, Alebel A. Predictors of mortality in patients with drug-resistant tuberculosis: A systematic review and meta-analysis. PLoS One. 2021;16(6 June):1–24. Available from: 10.1371/journal.pone.0253848
  5. Kliman Kai, Altraja Alan. Annals of Internal Medicine Predictors of Extensively Drug-Resistant Pulmonary Tuberculosis. Ann Intern Med. 2005;(12).
  6. Soeroto AY, Pratiwi C, Santoso P, Lestari BW. Factors affecting outcome of longer regimen multidrug-resistant tuberculosis treatment in West Java Indonesia: A retrospective cohort study. PLoS One. 2021;16(2 February):1–13. Available from: 10.1371/journal.pone.0246284
  7. Sakundano M, Jazuli N. TB community empowerment model instruments in finding tuberculosis (TB) suspects. Bali Med J. 2022;11(2):551–4.
  8. Philip J, John S, Iyer P. Antimicrobial activity of Aloevera barbedensis, Daucus carota, Emblica officinalis, Honey and Punica granatum and formulation of a health drink and salad. Malays J Microbiol. 2012;8(3):141–7.
  9. Alemdar S, Agaoglu S. Investigation of in vitro antimicrobial activity of Aloe vera juice. Vol. 8, Journal of Animal and Veterinary Advances. 2009. p. 99–102.
  10. Nejatzadeh-Barandozi F. Antibacterial activities and antioxidant capacity of Aloe vera. Org Med Chem Lett. 2013;3(1):5. Available from: 10.1371/journal.pone.0253848
  11. Jana K, Chatterjee K, Ali K, Ghosh A, Bera T, Ghosh D. Antioxidant potential of hydro-methanolic extract of seed of Caesalpinia bonduc: An in vitro study. J Adv Pharm Technol Res. 2011;2(4):260–5. Available from: 10.4103/2231-4040.90884
  12. Umamaheswari M, Chatterjee T. In vitro antioxidant activities of the fractions of Coccinia grandis l. leaf extract. African J Tradit Complement Altern Med. 2008;5(1):61–73. Available from: 10.4314/ajtcam.v5i1.31258
  13. Taukoorah U, Mahomoodally MF. Crude Aloe vera Gel Shows Antioxidant Propensities and Inhibits Pancreatic Lipase and Glucose Movement in Vitro. Adv Pharmacol Sci. 2016;2016. Available from: 10.1155/2016/3720850
  14. Miller A, Collection A, Sample P. Antifungal and Antioxidant Activities. World Acad Sci Eng Technol. 2011;2009–11.
  15. Hes M, Dziedzic K, Gorecka D, Jedrusek-Golińska A, Gujska E. Aloe vera (L.) Webb.: Natural Sources of Antioxidants – A Review. Plant Foods Hum Nutr. 2019;74(3):255–65. Available from: 10.1007/s11130-019-00747-5
  16. Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP. Pharmacological update properties of aloe vera and its major active constituents. Molecules. 2020;25(6):1–37. Available from: 10.3390/molecules25061324
  17. Nguta JM, Appiah-Opong R, Nyarko AK, Yeboah-Manu D, Addo PGA, Otchere ID, et al. In vitro antimycobacterial and cytotoxic data on medicinal plants used to treat tuberculosis. Data Br. 2016;7:1124–30. Available from: 10.1016/j.dib.2016.03.088
  18. Tiwari P, Kumar B, Kaur M, Kaur G, Kaur H. Phytochemical screening and extraction: a review. Int Pharm Sci. 2011;1(1):98–106.

How to Cite

Mawarti, H., Rajin, M., Khusniyah, Z., Asumta, Z. ., Khotimah, & Christina Destri Wiwis Wijayanti. (2022). Aloe vera and its potency as antituberculosis against strains of Mycobacterium tuberculosis that is resistant to some tuberculosis drugs. Bali Medical Journal, 11(3), 1879–1883.




Search Panel