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A study of efficacy, safety, and acceptance of two combined oral contraceptive pills containing 150 mcg Levonorgestrel and 30 mcg Ethinyl Estradiol at Dr. Kariadi Hospital, Semarang, Indonesia

  • Syarief Thaufik Hidayat ,
  • Hary Tjahjanto ,
  • Robert Eria ,
  • Yenny Kartika Gozali ,


Background: Combine Oral Contraceptives (COCs) pills is one of the many popular contraceptives worldwide, with 100 million women who use contraceptive pills. To increase the choice of oral contraceptives, COCs Novadiol® (Pill A) domestic production, which has the same dosage as Microgynon® (Pill B), are still imported drugs. This study aims to determine Pill A's efficacy, safety and acceptance level compared to Pill B for 3 months.

Methods: The study was a randomized control clinical trial, an open-label trial in 200 women of childbearing age who met the inclusion and exclusion criteria from July to November 2015. Data were analyzed using SPSS version 20 for Windows.

Results: About 300 participants were selected and 200 met the inclusion and exclusion criteria who participated study from the beginning to the end of the study period. In the first month of observation, 1 complaint of dizziness in pill A and 2 from pill B. One nausea complaint was found in the participant from Pill A. These differences were not statistically significant (p>0.05). In the second month of observation, 1 complained of dizziness from pill B and 1 nausea from Pill A. In the third month, observation found no complaints about using Pill A and pill B. There were changes in menstrual patterns in both pills and bleeding outside the cycle during the use of 3 months, but they were not statistically significant (p>0.05).

Conclusion: Pills A has the same efficacy, safety and acceptance when compared to the use of birth control pills B for 3 months.


  1. Gaffikin L, Engelman R. Family planning as a contributor to environmental sustainability: weighing the evidence. Curr Opin Obstet Gynecol. 2018;30(6):425-431.
  2. Burkman R, Bell C, Serfaty D. The evolution of combined oral contraception: improving the risk-to-benefit ratio. Contraception. 2011;84(1):19-34.
  3. Brown EJ, Deshmukh P, Antell K. Contraception Update: Oral Contraception. FP essentials. 2017;462:11-9.
  4. Maguire K, Westhoff C. The state of hormonal contraception today: established and emerging noncontraceptive health benefits. American journal of obstetrics and gynecology. 2011;205(4):S4-S8.
  5. Gayatri M, Utomo B. Contraceptive method use in Indonesia: Trends and Determinants between 2007, 2012 and 2017. Indian Journal of Public Health Research & Development. 2019;10(12):1818-1823.
  6. Kistiana S, Gayatri M, Sari DP. Determinants of Modern Contraceptive Use among Young Married Women (Age 15-24) in Indonesia. Global Journal of Health Science. 2020;12(13):1-37.
  7. Caserta D, Ralli E, Matteucci E, Bordi G, Mallozzi M, Moscarini M. Combined oral contraceptives: health benefits beyond contraception. Panminerva medica. 2014;56(3):233-44.
  8. Schindler AE. Non-contraceptive benefits of oral hormonal contraceptives. International journal of endocrinology and metabolism. 2013;11(1):41-47.
  9. Iversen L, Sivasubramaniam S, Lee AJ, Fielding S, Hannaford PC. Lifetime cancer risk and combined oral contraceptives: the Royal College of General Practitioners’ Oral Contraception Study. American journal of obstetrics and gynecology. 2017;216(6):580.e1-580.e9.
  10. Dragoman MV. The combined oral contraceptive pill-recent developments, risks and benefits. Best practice & research Clinical obstetrics & gynaecology. 2014;28(6):825-834.
  11. Dhont M. History of oral contraception. The European Journal of Contraception & Reproductive Health Care. 2010;15(sup2):S12-S8.
  12. Regidor P-A. Clinical relevance in present day hormonal contraception. Hormone molecular biology and clinical investigation. 2018;37(1):1-11.
  13. Stewart M, Black K. Choosing a combined oral contraceptive pill. Australian prescriber. 2015;38(1):6-11.
  14. Redha WSA. Effect of practice sports activity on some blood parameters and lipids profile in women taking Microgynon pills. Journal of Education for Pure Science. 2017;7(1):69-80.
  15. Mahdalena, Jusuf NK, Putra IB. Melasma characteristic in hormonal contraceptive acceptors at Kelurahan Mangga Kecamatan Medan Tuntungan, Medan-Indonesia. Bali Medical Journal. 2018;7(3):645-649.
  16. Laporan Pendahuluan. Badan Pusat Statistik, Badan Kependudukan dan Keluarga Berencana Nasional, Kementerian Kesehatan. MEASURE DHS, ICF International; 2012.
  17. Kiley J, Hammond C. Combined oral contraceptives: a comprehensive review. Clinical obstetrics and gynecology. 2007;50(4):868-77.
  18. Curtis KM, Chrisman CE, Mohllajee AP, Peterson HB. Effective use of hormonal contraceptives: part I: combined oral contraceptive pills. Contraception. 2006;73(2):115-124.
  19. Todd N, Black A. Contraception for adolescents. Journal of clinical research in pediatric endocrinology. 2020;12(Suppl 1):28-40.
  20. Thompson B, Almarjawi A, Sculley D, de Jonge XJ. The effect of the menstrual cycle and oral contraceptives on acute responses and chronic adaptations to resistance training: a systematic review of the literature. Sports Medicine. 2020;50(1):171-185.
  21. Shakya Shrestha S, Shrestha R, Shrestha S, Koju P, Shrestha A. Hormonal Contraceptives Use and Their Adverse Effects: A Cross-Sectional Study among the Women Visiting Tertiary Care Center. Kathmandu Univ Med J. 2020;71(3):296-302.
  22. Hee L, Kettner LO, Vejtorp M. Continuous use of oral contraceptives: an overview of effects and side‐effects. Acta obstetricia et gynecologica Scandinavica. 2013;92(2):125-136.
  23. Warren AM, Gurvich C, Worsley R, Kulkarni J. A systematic review of the impact of oral contraceptives on cognition. Contraception. 2014;90(2):111-116.
  24. Poromaa IS, Segebladh B. Adverse mood symptoms with oral contraceptives. Acta obstetricia et gynecologica Scandinavica. 2012;91(4):420-427.
  25. Römer T. Medical eligibility for contraception in women at increased risk. Deutsches Ärzteblatt International. 2019;116(45):764.
  26. Ornello R, Canonico M, Merki-Feld GS, Kurth T, Lidegaard Ø, MacGregor EA, et al. Migraine, low-dose combined hormonal contraceptives, and ischemic stroke in young women: a systematic review and suggestions for future research. Expert review of neurotherapeutics. 2020;20(4):313-317.
  27. Lee J-JM, Tan TC, Ang SB. Female sexual dysfunction with combined oral contraceptive use. Singapore medical journal. 2017;58(6):285.
  28. Zimmerman Y, Eijkemans M, Coelingh Bennink H, Blankenstein M, Fauser B. The effect of combined oral contraception on testosterone levels in healthy women: a systematic review and meta-analysis. Human reproduction update. 2014;20(1):76-105.
  29. Vijayaalakshmi L. Drugs Inducing Oro-Facial Pigmentation-A Short Review. Journal of Pharmaceutical Sciences and Research. 2015;7(7):458-460.
  30. Burrows LJ, Basha M, Goldstein AT. The effects of hormonal contraceptives on female sexuality: a review. The journal of sexual medicine. 2012;9(9):2213-2223.
  31. Słopień R, Milewska E, Rynio P, Męczekalski B. Use of oral contraceptives for management of acne vulgaris and hirsutism in women of reproductive and late reproductive age. Prz Menopauzalny. 2018;17(1):1-4.
  32. Mawet M, Maillard C, Klipping C, Zimmerman Y, Foidart J-M, Coelingh Bennink HJ. Unique effects on hepatic function, lipid metabolism, bone and growth endocrine parameters of estetrol in combined oral contraceptives. The European Journal of Contraception & Reproductive Health Care. 2015;20(6):463-475.
  33. Kasal DAB, Lorenzo AD. Oral Contraceptives and Cardiovascular Risk: Adding Clinical Evidence to the Pathophysiology. International Journal of Cardiovascular Sciences. 2020;33(3):215-6.
  34. Shufelt C, LeVee A. Hormonal contraception in women with hypertension. Jama. 2020;324(14):1451-1452.

How to Cite

Hidayat, S. T., Tjahjanto, H. ., Eria, R., & Gozali, Y. K. (2022). A study of efficacy, safety, and acceptance of two combined oral contraceptive pills containing 150 mcg Levonorgestrel and 30 mcg Ethinyl Estradiol at Dr. Kariadi Hospital, Semarang, Indonesia. Bali Medical Journal, 11(3), 1290–1300.




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Syarief Thaufik Hidayat
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Hary Tjahjanto
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Robert Eria
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Yenny Kartika Gozali
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