Skip to main content Skip to main navigation menu Skip to site footer

Restarting living donor kidney transplant during COVID-19: a single center experience

  • Mochammad Fairuz Zahran ,
  • Tanaya Ghinorawa ,


Abstract

Abstract: The decision that declared COVID-19 as a pandemic in March 2020 had become a medical emergency that also effects kidney transplantation program and care. Kidney transplantation has been a definitive treatment for end-stage renal disease (ESRD) patients since it improves patient’s quality of life. However great the beneficence is, kidney transplant procedure still carries high risk of COVID-19 infection especially for recipients who are obliged to take immunosuppression agents after transplantation.

Purpose: This study aimed to evaluate kidney transplant procedure in Dr. Sardjito General Hospital within before and during pandemic based on recipients’ and donors’ characteristics and laboratory findings such as creatinine and urine time.

Patients and methods: This study is designed as a cross-sectional analytic research to evaluate 30 patients that underwent kidney transplant in Dr. Sardjito General Hospital within before (April 2019-2020) and during (April 2020-2021) COVID-19 era. Data analyses were carried out using SPSS version 25.0 and were served with simple charts and tables.

Results: There is a decrement of kidney transplant procedure within before (n=16) and during (n=14) COVID-19. Age group of recipients that underwent the most of transplantation before pandemic are 20-29 years old while during pandemic are 40-49 years old. There is no significant difference in length-of-stay within before (12.0±4.17 days) and during (9.29±3.73 days) COVID-19 (p=0,077). Laboratory findings such as creatinine of pre-transplantation (9.47±4.05; 7.81±6.00) and 3 months’ post-transplantation (1,55±0,78; 1,15±0,67) also did not show significant changes (p=0,153) as well as urine time (245.60±225.55; 428.38±657.70; p=0.321).

Conclusion: There is a decrement of kidney transplant procedure in Dr. Sardjito General Hospital within before and during COVID-19 era. There are no significant differences found within length-of-stay, creatinine pre and 3 months’ post-transplantation and urine time. On the whole, transplant outcomes have remained similar within pre and during COVID-19 era.

Keywords: kidney transplantation COVID-19 pandemic

References

  1. Ju C, Lian Q, Zhang J et al. Recommended prophylactic and management strategies for severe acute respiratory syndrome coronavirus 2 infection in transplant recipients. Chronic Dis Transl Med. 2020;6(2):87-97. doi:10.1016/j.cdtm.2020.02.003
  2. Peta Sebaran. COVID-19 KPCPEN. https://covid19.go.id/. Published 2022. Accessed July 23, 2022.
  3. Lentine K, Mannon R, Josephson M. Practicing With Uncertainty: Kidney Transplantation During the COVID-19 Pandemic. American Journal of Kidney Diseases. 2021;77(5):777-785. doi:10.1053/j.ajkd.2020.12.003
  4. Situasi Penyakit Ginjal Kronis. Pusdatin.kemkes.go.id. https://pusdatin.kemkes.go.id/resources/download/pusdatin/infodatin/infodatin-ginjal-2017.pdf. Published 2017. Accessed July 23, 2022.
  5. Akalin E, Azzi Y, Bartash R et al. Covid-19 and Kidney Transplantation. New England Journal of Medicine. 2020;382(25):2475-2477. doi:10.1056/nejmc2011117
  6. Aziz F, Muth B, Parajuli S et al. Unusually high rates of acute rejection during the COVID-19 pandemic: cause for concern?. Kidney Int. 2020;98(2):513-514. doi:10.1016/j.kint.2020.05.038
  7. Dewi M. KEBIJAKAN TRANSPLANTASI GINJAL DI INDONESIA. Buletin Penelitian Sistem Kesehatan. 2018;21(1):32-40. doi:10.22435/hsr.v21i1.97
  8. Boyarsky B, Po‐Yu Chiang T, Werbel W et al. Early impact of COVID‐19 on transplant center practices and policies in the United States. American Journal of Transplantation. 2020;20(7):1809-1818. doi:10.1111/ajt.15915
  9. Loupy A, Mengel M, Haas M. Thirty years of the International Banff Classification for Allograft Pathology: the past, present, and future of kidney transplant diagnostics. Kidney Int. 2022;101(4):678-691. doi:10.1016/j.kint.2021.11.028
  10. Vistoli F, Furian L, Maggiore U et al. COVID-19 and kidney transplantation: an Italian Survey and Consensus. J Nephrol. 2020;33(4):667-680. doi:10.1007/s40620-020-00755-8
  11. Peluso G, Campanile S, Scotti A et al. COVID-19 and Living Donor Kidney Transplantation in Naples during the Pandemic. Biomed Res Int. 2020;2020:1-4. doi:10.1155/2020/5703963
  12. Pascual J, Melilli E, Jiménez-Martín C et al. COVID-19–related Mortality During the First 60 Days After Kidney Transplantation. Eur Urol. 2020;78(4):641-643. doi:10.1016/j.eururo.2020.06.036
  13. Cordero E, Pérez-Romero P, Moreno A et al. Pandemic influenza A(H1N1) virus infection in solid organ transplant recipients: impact of viral and non-viral co-infection. Clinical Microbiology and Infection. 2012;18(1):67-73. doi:10.1111/j.1469-0691.2011.03537.x
  14. Incollingo P, Peluso G, Pelosio L et al. Ethical Issues in the Use of Suboptimal Kidneys for Transplants: An Italian Point of View. Transplant Proc. 2019;51(1):106-110. doi:10.1016/j.transproceed.2018.05.031
  15. Khairallah P, Aggarwal N, Awan A et al. The impact of COVID‐19 on kidney transplantation and the kidney transplant recipient – One year into the pandemic. Transplant International. 2021;34(4):612-621. doi:10.1111/tri.13840
  16. Golder HJ, Papalois V. Enhanced recovery after surgery: History, key advancements and developments in transplant surgery. Journal of Clinical Medicine. 2021;10(8). doi:10.3390/jcm10081634
  17. Elec AD, Oltean M, Goldis P, et al. COVID-19 after kidney transplantation: Early outcomes and renal function following antiviral treatment. International Journal of Infectious Diseases. 2021;104:426-432. doi:10.1016/j.ijid.2021.01.023

How to Cite

Mochammad Fairuz Zahran, & Tanaya Ghinorawa. (2022). Restarting living donor kidney transplant during COVID-19: a single center experience. Bali Medical Journal, 11(3), 1380–1386. https://doi.org/10.15562/bmj.v11i3.3615
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver
Download Citation
Endnote/Zotero/Mendeley (RIS) BibTeX

HTML
0

Total
0

Share

Search Panel

Mochammad Fairuz Zahran
Google Scholar
Pubmed
BMJ Journal

Tanaya Ghinorawa
Google Scholar
Pubmed
BMJ Journal