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Brazilian propolis wax as an anti-type-IV-hypersensitivity agent in metal bracket orthodontic treatment

  • Grahita Aditya ,
  • Oedijani Santoso ,
  • Lisyani Budipradigdo Suromo ,

Abstract

Background: Nickel (Ni2+) allergy on the mucosa and gingiva is frequently found in patients with fixed metal orthodontic treatment as the manifestation of type-IV hypersensitivity reactions.

Method: This study aims to observe the effect of Brazilian propolis wax on salivary Ni2+ ion levels and blood serum IFN-γ and IL-10 levels during fixed metal bracket orthodontic treatment. A total of 34 New Zealand rabbits were divided into three groups. Before the treatment, Ni2+sensitization was done using a 125 μL NiCl2 injection. Metal brackets were placed on the four anterior teeth for 28 days. Saliva was carried out for Ni2+ ion level analysis by inductively coupled plasma-optical emission spectrometry (ICP-OES), and ELISA measured peripheral blood serum for IFN-γ and IL-10 level analysis.

Result: Ni2+ ion release in the control group showed a higher expression than in the wax and propolis-wax groups. IFN-γ expression level is reduced in the wax and propolis-wax group than in the control group. Moreover, a significantly different IL-10 expression was also observed in the wax and propolis-wax groups.

Conclusion: The combination of propolis into wax orthodontic inhibits Ni2+ ion release by promoting anti-inflammatory IL-10 expression.

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How to Cite

Grahita Aditya, Oedijani Santoso, & Lisyani Budipradigdo Suromo. (2022). Brazilian propolis wax as an anti-type-IV-hypersensitivity agent in metal bracket orthodontic treatment. Bali Medical Journal, 11(3), 2052–2056. https://doi.org/10.15562/bmj.v11i3.3583

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