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Crosstalk between hypoxia and inflammation in non-Hodgkin lymphoma

  • Eko Adhi Pangarsa ,
  • Daniel Rizky ,
  • Budi Setiawan ,
  • Damai Santosa ,
  • Sofia Mubarika Haryana ,
  • Catharina Suharti ,


Abstract

Tumor hypoxia is a well-known biological circumstance that has an impact on cancer growth and metastasis. This phenomenon is associated with poor patient outcomes, particularly in patients with non-Hodgkin lymphoma. As the tumor mass grows, aggressive lymphoid malignancies necessitate a constant increase in perfusion, activating the hypoxia-inducible factor (HIF)-1α. HIF-1α is an important regulator widely discussed in various studies and pathological states that influence the expression of several genes through transcriptional regulation, including metabolism/respiration, cell cycle, apoptosis, proliferation, angiogenesis, and others that may favor tumor growth. Tumor hypoxia also induces the expression of other important regulators, such as microRNA-210 (miR-210) and Nuclear Factor Kappa B (NF-κB), which propagate the tumorigenesis process. This article reviewed the molecular mechanisms of how HIF-1α correlates with NF-κB and other factors in non-Hodgkin lymphoma patients.

Keywords: Tumor hypoxia non-Hodgkin Lymphoma HIF-1α miR-210 NF-κB

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How to Cite

Adhi Pangarsa, E., Rizky, D., Setiawan, B., Santosa, D., Mubarika Haryana, S., & Suharti, C. (2022). Crosstalk between hypoxia and inflammation in non-Hodgkin lymphoma. Bali Medical Journal, 11(3), 1063–1073. https://doi.org/10.15562/bmj.v11i3.3491
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Eko Adhi Pangarsa
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Daniel Rizky
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Budi Setiawan
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Damai Santosa
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Sofia Mubarika Haryana
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Catharina Suharti
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