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Clinical and laboratory comparison between End-Stage Kidney Disease patients with and without COVID-19: a cross-sectional study in a top referred hospital of West Nusa Tenggara

  • I Gede Yasa Asmara ,
  • I Gusti Ngurah Ommy Agustriadi ,
  • I Made Sujaya ,
  • Salim Said Thalib ,
  • Rina Lestari ,
  • Suryani Padua Fatrullah ,
  • Komang Sri Rahayu Widiasari ,
  • Indana Eva Ajmala ,
  • Metta Octora ,


Abstract

Background: The initial presentation of hospitalized End-Stage Kidney Disease (ESKD) patients with and without coronavirus disease 2019 (COVID-19) is similar and can overlap. We aimed to compare clinical dan laboratory characteristics of the COVID-19 positive and negative patients to help clinicians screen and differentiate hospitalized ESKD patients.

Methods: We reviewed data from the medical record of ESKD patients hospitalized between May 1, 2020, and April 30, 2021. The study comprised all suspected COVID-19 patients. The COVID-19 positive was based on results from RT-PCR for SARS-CoV-2. The bivariate analysis was used to compare the positive and negative groups. The association of all characteristics and diagnosis of COVID-19 were then evaluated by multivariable analysis.

Results: There was twenty-nine percent of confirmed COVID-19 in 176 ESKD patients. The proportion of dyspnea, pulmonary edema, pleural effusion, and cardiomegaly were lower in the COVID-19 positive group. Diastolic blood pressure, pulse rate, white blood cell differential counts, and potassium were lower in the COVID-19 positive group. Using a multivariate analysis, eosinophil count <0.04 x103µl (P<0.001, OR 3.50, 95%CI:0.123-0.665), monocyte count <0.69 x103µl (P=0.004, OR 2.54, 95%CI:0.166-0.931), and neutrophil-to-lymphocyte ratio (NLR) <3.13 (P=0.044, OR 3.18, 95%CI:0.102-0.968) were associated with the presence of COVID-19.

Conclusions: Leukocyte differential count and chest x-ray should be evaluated as an initial screening of COVID-19 in hospitalized ESKD. Low levels of monocyte and eosinophil count and mild elevation of NLR were associated with COVID-19 in ESKD patients.

Keywords: COVID-19 ESKD Eosinophil Monocyte NLR

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How to Cite

Asmara, I. G. Y., Agustriadi, I. G. N. O., Sujaya, I. M., Thalib, S. S., Lestari, R., Fatrullah, S. P., Widiasari, K. S. R., Ajmala, I. E., & Octora, M. (2022). Clinical and laboratory comparison between End-Stage Kidney Disease patients with and without COVID-19: a cross-sectional study in a top referred hospital of West Nusa Tenggara. Bali Medical Journal, 11(3), 1074–1079. https://doi.org/10.15562/bmj.v11i3.3440
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I Gede Yasa Asmara
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I Gusti Ngurah Ommy Agustriadi
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I Made Sujaya
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Salim Said Thalib
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Rina Lestari
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Suryani Padua Fatrullah
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Komang Sri Rahayu Widiasari
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Indana Eva Ajmala
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Metta Octora
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