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Quran recitation as noise-induced aggression and resilience in animal model of depression


Introduction: This research analyzes the behavioral and biological concepts of depression, aggression, and resilience. It also analyzes the Quran recitation as a noise-inducer for aggression but also encouraging intervention for depression.

Method: Experimental research with a post-test-only control group design created an agitated depression model in mice as a basis for understanding the biological concepts of aggression. Healthy mice (Mus musculus balb/c) aged 10-12 weeks, weighing 20-25 grams, were random-allocated into 9 (nine) groups, namely the control group (K_ negative, depression, and aggression), depression group (DP_1, 2, 3), and aggression group (AP_1, 2, 3). The tail suspension approach triggered helplessness to form a depression model. Quran recitation was performed above 60 decibels as noise exposure triggers agitation and forms an aggression model. QRP performed under 60 decibels was assumed to create a resilience model. Depression, aggression, and resilience were measured using an eight-arm radial maze (TM) and immobile time when hung (TG). After the intervention, mice were sacrified and the brains harvested. Normal cells were counted in the average of ten microscopic fields using 40x objective lens magnification and HE staining.

Results: The QRP alleviated the psychomotor retardation in the depression group, while the aggression group experienced a goal-directed behavioral activation as the cognition increased with psychomotor calm. Neuron cells were significantly different among groups; the optimum QRP dose was an hour once a day.

Conclusions: The QRP intervention can improve depression and aggression, but also a source of noise-induced stress at a higher frequency. These results should be carefully generalized and need further research.


  1. Nayef EG, Wahab MNA. The Effect of Recitation Quran on the Human Emotions. Int J Acad Res Bus Soc Sci. 2018;8(2).
  2. Zarea Gavgani V, Ghojazadeh M, Sadeghi-Ghyassi F, Khodapanah T. Effects of listening to Quran recitation on anxiety reduction in elective surgeries: A systematic review and meta-analysis. Arch Psychol Relig. 2022;008467242211021.
  3. Ghiasi A, Keramat A. The effect of listening to holy quran recitation on anxiety: A systematic review. Iran J Nurs Midwifery Res. 2018;23(6):411–20.
  4. Mehrafsar A, Mokhtari MJ. Effect of Exposure to Quran Recitation on Cell Viability, Cell Migration, and BCL2L12 Gene Expression of Human Prostate Adenocarcinoma Cell Line in Culture. Heal Spiritual Med Ethics. 2018;5(4):46–52.
  5. Vaghefi M, Nasrabadi A, Hashemi Golpayegani S, Mohammadi M, Gharibzadeh S. Nonlinear analysis of electroencephalogram signals while listening to the holy Quran. J Med Signals Sens. 2019;9(2):100–10.
  6. Jasim MH, Salih MM, Abdulwahhab ZT, Shouwandy ML, Ahmed MA, ALsalem MA, et al. Emotion Detection among Muslims and Non- Muslims While Listening to Quran Recitation Using EEG. Int J Acad Res Bus Soc Sci. 2019;9(14).
  8. Algristian H. Kontra-Terorisme: Seandainya Dunia Tanpa Islam. Duta Masyarakat. 2018;
  9. Rusnalasari ZD, Algristian H, Alfath TP, Arumsari AD, Inayati I. Students Vulnerability and Literacy Analysis Terrorism Ideology Prevention. J Phys Conf Ser. 2018;1028(1):012089.
  10. Richter SH, Zeuch B, Lankisch K, Gass P, Durstewitz D, Vollmayr B. Where Have I Been? Where Should I Go? Spatial Working Memory on a Radial Arm Maze in a Rat Model of Depression. PLoS One. 2013;8(4):e62458.
  11. Baribault H. Mouse Models for Drug Discovery. Methods Mol Biol. 2010;602(January):135–55.
  12. Cryan JF, Mombereau C. In search of a depressed mouse: Utility of models for studying depression-related behavior in genetically modified mice. Mol Psychiatry. 2004;9(4):326–57.
  13. Taliaz D, Stall N, Dar DE, Zangen A. Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis. Mol Psychiatry. 2010;15(1):80–92.
  14. Stukalin Y, Lan A, Einat H. Revisiting the validity of the mouse tail suspension test: Systematic review and meta-analysis of the effects of prototypic antidepressants. Neurosci Biobehav Rev. 2020;112:39–47.
  15. Jafari Z, Kolb BE, Mohajerani MH. Chronic traffic noise stress accelerates brain impairment and cognitive decline in mice. Exp Neurol. 2018;308:1–12.
  16. Qiao Y, Zhao J, Li C, Zhang M, Wei L, Zhang X, et al. Effect of combined chronic predictable and unpredictable stress on depression-like symptoms in mice. Ann Transl Med. 2020;8(15):942–942.
  17. Korsós G, Horváth K, Lukács A, Vezér T, Glávits R, Fodor K, et al. Effects of accelerated human music on learning and memory performance of rats. Appl Anim Behav Sci. 2018;202(2000):94–9.
  18. Sanyal T, Palanisamy P, Nag TC, Roy TS, Wadhwa S. Effect of prenatal loud music and noise on total number of neurons and glia, neuronal nuclear area and volume of chick brainstem auditory nuclei, field L and hippocampus: A stereological investigation. Int J Dev Neurosci. 2013;31(4):234–44.
  19. Chaudhuri S. the Effects of Music on Stress. Int J Adv Res. 2021;9(02):524–38.
  20. Azizah AS N, Veterini L, Algristian H, Salim HM. Expression of Brain-Derived Neurotrophic Factor in the Brain of Depressed Mice: Systematic Literature Review. Qanun Med - Med J Fac Med Muhammadiyah Surabaya. 2021;5(2):189–203.
  21. Liu L, Xuan C, Shen P, He T, Chang Y, Shi L, et al. Hippocampal mechanisms underlying impairment in spatial learning long after establishment of noise-induced hearing loss in CBA mice. Front Syst Neurosci. 2018;12:35.

How to Cite

Algristian, H., Bintari, T. W., Iradatus Solihah, Andik Ferdiantoro, Fatmanagri Napstyawati, & Handajani, R. . (2022). Quran recitation as noise-induced aggression and resilience in animal model of depression. Bali Medical Journal, 11(2), 994–1002.




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Hafid Algristian
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Tri Wahyu Bintari
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Iradatus Solihah
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Andik Ferdiantoro
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Fatmanagri Napstyawati
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Retno Handajani
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