TNF-a serum Level between SARS-CoV-2 Infected Pregnant women with normal pregnant women in RSUD Dr. Soetomo Surabaya
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- DOI: https://doi.org/10.15562/bmj.v11i1.3377 |
- Published: 2022-03-23
Open Access & Peer Reviewed Multidisciplinary
Journal of Medical Sciences
Journal of Medical Sciences
Abstract
Introduction: Pregnant women infected with SARS-CoV-2 experienced increased pro-inflammatory cytokines, including TNF-a, resulting in a cytokine storm condition. This study compares TNF-a levels between pregnant women infected and not infected with Covid-19 in the 3rd trimester.
Methods: This observational research was conducted with cross sectional design. Our study included pregnant women who came to delivery room/inpatient at RSUD Dr. Soetomo Surabaya before or during the labor period between May and June in 2021. The inclusion criteria were 3rd trimester gestational age or > 28 weeks with SARS-RT-PCR nasopharyngeal swab result. The exclusion criteria were all significant pregnancy complications. The pregnant woman coming to the delivery room will be screened for COVID-19, and blood samples will be examined using the flow cytometry method for the cytokine Th1: TNF-?.
Results: There were no significant differences in TNF-a levels in pregnant women who were infected and not infected with COVID-19 (median 3.42 (7.24) pg/ml vs. 2.70 (3.06) pg/ml. p=0.138). There were also no significant differences in TNF-a levels in pregnant women with symptomatic vs. asymptomatic COVID infection (3.21(3.97) vs. 2.41(2.71) pg/ml; p=0.314).
Conclusion: This study revealed no significant difference in TNF-a serum level between SARS-CoV-2 infected pregnant women with normal pregnant women.
References
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2. Mor, G. dan Cardenas, I. 'The immune system in pregnancy: a unique complexity'. American Journal of Reproductive Immunology 2010: 63(6): 425–433. doi: 10.1111/j.1600-0897.2010.00836.x.
3. Yockey, L.J. dan Iwasaki, A. 'Interferons and pro-inflammatory cytokines in pregnancy and fetal development'. Immunity. Elsevier Inc., 2018: 49(3): 397–412. doi: 10.1016/j.immuni.2018.07.017.
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5. Costela-Ruiz, V.J. Illescas-Montes, R. Puerta-Puerta, J.M. Ruiz, C. Melguizo-Rodríguez, L. 'SARS-CoV-2 infection: the role of cytokines in COVID-19 disease'. Cytokine and Growth Factor Reviews. Elsevier 2020;54(June): 62–75. doi: 10.1016/j.cytogfr.2020.06.001.
6. Ruan, Q. et al. 'Clinical predictors of mortality due to COVID ? 19 based on an analysis of data of 150 patients from Wuhan , China'. 2020
7. Wardhana, M. P., Dachlan, E.G., Aditiawarman, Ernawati, Maniora, N.C., Aditya, R., Habibie, P.H., Gumilar, K.E., Wicaksono, B., Akbar, M.I.A., Sulistyono, A., Juwono, H.T. Maternal and perinatal outcome of covid-19 in obstetric cases : 9 months experience from east java tertiary re- ferral hospital, The New Armenian medical Journal 2021;5:39–46.
8. Ying Chi, Yiyue Ge, Bin Wu, Wenshuai Zhang, Tao Wu, Tian Wen, Jingxian Liu, Xiling Guo, Chao Huang, Yongjun Jiao, Fengcai Zhu, Baoli Zhu, Lunbiao Cui, Serum Cytokine and Chemokine Profile in Relation to the Severity of Coronavirus Disease 2019 in China, The Journal of Infectious Diseases 2020;222(5): 746–754, https://doi.org/10.1093/infdis/jiaa363
9. Karki, R. Sharma, B.R. Tuladhar, S. Williams, E.P. Zalduondo, L. Samir, P. Zheng, M. Sundaram, B. Banoth, B. Malireddi, R.K.S. Kanneganti, T.D. 'Synergism of TNF-? and IFN-? triggers inflammatory cell death, tissue damage, and mortality in SARS-Cov-2 infection and cytokine shock syndromes'. Cell 2020;184(1):149–168.
10. Salomon BL, Leclerc M, Tosello J, Ronin E, Piaggio E, Cohen JL. Tumor Necrosis Factor ? and Regulatory T Cells in Oncoimmunology. Front Immunol 2018 Mar 12;9:444. doi: 10.3389/fimmu.2018.00444. PMID: 29593717; PMCID: PMC5857565.
11. Chan, H.L.Y. Tsui, S.K.W. Sung, J.J.Y. 'Coronavirus in severe acute respiratory syndrome (SARS)'. Trends in Molecular Medicine 2003: 9(8):323–325. doi: 10.1016/S1471-4914(03)00135-7.
12. Han H, Ma Q, Li C, et al. Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors. Emerg Microbes Infect. 2020;9(1):1123-1130. doi:10.1080/22221751.2020.1770129
13. Chen, J. et al. 'Cellular Immune Responses to Severe Acute Respiratory Syndrome Coronavirus ( SARS-CoV ) Infection in Senescent BALB / c Mice?: CD4 ? T Cells Are Important in Control of SARS-CoV Infection 2010; 84(3):1289–1301. doi: 10.1128/JVI.01281-09.
How to Cite
Febryanna, M. C., Wardhana, M. P., Akbar, M. I. A., & Nurdianto, A. R. (2022). TNF-a serum Level between SARS-CoV-2 Infected Pregnant women with normal pregnant women in RSUD Dr. Soetomo Surabaya. Bali Medical Journal, 11(1), 112–115. https://doi.org/10.15562/bmj.v11i1.3377
