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The difference of platelet-white blood cell ratio in severe preeclampsia and normotensive pregnancy



Abstract

Background: Inflammation is believed to play a role in preeclampsia. Leukocytes increase due to inflammatory response. Endothelial damage in preeclampsia induces platelet aggregation, triggers platelet consumption, and decreases platelet. Therefore, preeclampsia could alter the platelet-white blood cell ratio, which can be used as a marker for preeclampsia. This study examines the difference of platelet-white blood cell ratio in severe preeclampsia and normotensive pregnancy.

Methods: This study used the medical records of pregnant women in Dr. Kariadi General Hospital Semarang from 2019 to 2020. Samples were collected using a consecutive sampling method. Data were analyzed using an independent t-test and Mann-Whitney.

Results: There was a significant difference in platelet count (p=0.011) and leukocyte count (p=0.018) between severe preeclampsia and normotensive pregnancy. Therefore, a difference (p<0.01) in platelet-white blood cell ratio between severe preeclampsia and normotensive pregnancy was observed.

Conclusion: Platelet-white blood cell ratio in severe preeclampsia is 0.7 times lower than in normotensive pregnancy.

Keywords: inflammation severe preeclampsia platelet-white blood cell ratio

References

  1. World Health Organization. Trends in Maternal Mortality 2000 to 2017: estimates by WHO, UNICEF, UNFPA, World Bank Group and the United Nations Population Division. Geneva: World Health Organization; 2019. 31–40 p.
  2. Susiana S. Angka Kematian Ibu : Faktor Penyebab Dan Upaya Penanganannya. Info Singkat. 2019;11(24):13–8.
  3. Prabowo Y, Lutiarsi RT, Wibowo MA, Lestari ES, Istirochah, Sugiarto A, et al. Profil Kesehatan Provinsi Jawa Tengah Tahun 2019. Dinkes Jateng. Semarang: Dinas Kesehatan Provinsi Jawa Tengah; 2019. 42–43 p.
  4. Wibowo N, Irwinda R, Frisdiantiny E, Karkata MK, Mose JC, Chalid MT, et al. PNPK Diagnosis dan Tatalaksana Preeklampsia. Jakarta: POGI-HKFM; 2016. 6–25 p.
  5. Raras AA. Pengaruh Preeklamsia Berat Pada Kehamilan Terhadap Keluaran Maternal Dan Perinatal Di Rsup Dr Kariadi Semarang Tahun 2010. 2011;1–19.
  6. Utami N, Ayu PR, Puspitasari RD, Graharti R. Indeks Trombosit Pada Penderita Preeklampsia di RSUD DR. H. Abdul Moeloek Provinsi Lampung. Kedokt Unila. 2018;2(2):102–6.
  7. Yavuzcan A, Çaǧlar M, Üstün Y, Dilbaz S, Özdemir I, Yildiz E, et al. Mean platelet volume, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in severe preeclampsia. Ginekol Pol. 2014;85(3):197–203.
  8. Angelina M, Surya IGP, Agung Suwardewa TG. High sensitivity C-Reactive Protein dan leukosit serum yang tinggi merupakan faktor risiko terjadinya preeklampsia. Medicina (B Aires). 2019;50(1):123–8.
  9. Shen Y, Huang X, Zhang W. Platelet-to-lymphocyte ratio as a prognostic predictor of mortality for sepsis: Interaction effect with disease severity - A retrospective study. BMJ Open. 2019;9(1):1–7.
  10. Mannaerts D, Heyvaert S, De Cordt C, Macken C, Loos C, Jacquemyn Y. Are neutrophil/ lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and/or mean platelet volume (MPV) clinically useful as predictive parameters for preeclampsia? J Matern Neonatal Med. 2019;32(9):1412–9.
  11. Jie Y, Gong J, Xiao C, Zhu S, Zhou W, Luo J, et al. Low Platelet to White Blood Cell Ratio Indicates Poor Prognosis for Acute-On-Chronic Liver Failure. Biomed Res Int. 2018;2018:1–5.
  12. Akram W, Muaeed D. The significance of (platelet/white blood cell) counts ratio in screening for high risk for preeclampsia and its related complications. Mustansiriya Med J. 2019;18(1):36–42.
  13. Sumampouw CM, Tendean HMM, Wagey FW. Gambaran Preeklampsia Berat Dan Eklampsia Ditinjau Dari Faktor Risiko di RSUP Prof. DR. R. D. Kandou Manado. J Med dan Rehabil. 2019;1(3):1–5.
  14. Mamlukah, Saprudin A. Gambaran Karakteristik Ibu Hamil Dengan Risiko Preeklamsia. J Ilmu Kesehat Bhakti Husada. 2018;9(2):59–67.
  15. Insani U, Supriatun E. Determinan Kejadian Preeklampsia Pada Ibu Hamil Di Wilayah Kerja Uptd Puskesmas Dukuhwaru Slawi. J Ilm Kesehat Keperawatan. 2020;16(2):81–90.
  16. Desalegn N. Causes of Admission and out Comes Among Preeclampsia and Eclampsia Mothers Admitted to Jimma University Specialized Hospital Intensive Care Unit. Clin Med Res. 2015;4(5):154–9.
  17. Gupta A, Gaur BS, Mishra KB, Dubey I. A comparison of platelet count in severe preeclampsia, mild preeclampsia and normal pregnancy. Int J Res Med Sci. 2018;6(2):671–6.
  18. Kalam C, Wagey FW, Mongan SP. Luaran Ibu dan Perinatal pada Kehamilan dengan Preeklampsia Berat di RSUP Prof. Dr. R. D. Kandou Manado Periode 1 Januari - 31 Desember 2016. e-CliniC. 2017;5(2).
  19. Giyanto C, Pramono B. Perbandingan Profil Hematologi Pada Preeklampsia/ Eklampsia Dengan Kehamilan Normotensi Di Rsup Dr. Kariadi Semarang. J Kedokt Diponegoro. 2015;4(4):1726–35.
  20. Astuti WW, Suparni IE. Perbedaan Kadar Hemoglobin Pada Ibu Hamil Antara Preeklampsia Ringan Dan Preeklampsia Berat. J Cent Res Publ Midwifery Nurs. 2018;2(2):15– 9.
  21. Sitotaw C, Asrie F, Melku M. Evaluation of platelet and white cell parameters among pregnant women with Preeclampsia in Gondar, Northwest Ethiopia: A comparative cross-sectional study. Pregnancy Hypertens. 2018;13:242–7.
  22. Williams JW, Cunningham FG, Leveno KJ, Bloom SL, Spong CY, Dashe JS. Williams Obstetrics. 25th ed. New York: McGraw-Hill Education; 2018.
  23. Chandra S, Tripathi AK, Mishra S, Amzarul M, Vaish AK. Physiological changes in hematological parameters during pregnancy. Indian J Hematol Blood Transfus. 2012;28(3):144–6.
  24. Widyastiti N, Setianingrum E. Perbedaan Antara Rasio Neutrofil / Limfosit Dan Rasio Platelet / Limfosit Pada Kehamilan Normal, Preeklampsia Ringan Dan Berat. Cendana Med J. 2019;17(2014):334–40.
  25. Manoel AL de O, Macdonald RL. Neuroinflammation as a target for intervention in subarachnoid hemorrhage. Front Neurol. 2018;9(252):7.

How to Cite

Nur Safirani, N. A., Fulyani, F., Wiyati, P. S., & Pramono, B. A. (2022). The difference of platelet-white blood cell ratio in severe preeclampsia and normotensive pregnancy. Bali Medical Journal, 11(1), 414–417. https://doi.org/10.15562/bmj.v11i1.3246
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Nisrina Aisyah Nur Safirani
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Faizah Fulyani
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Putri Sekar Wiyati
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Besari Adi Pramono
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