Absolute Neutrophil Count as Predictor Hematopoietic Recovery in Acute Lymphoblastic Leukemia in Remission Induction Phase Chemotherapy
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- Published: 2022-04-30
Introduction: The main treatment for leukemia is chemotherapy therapy, divided into the induction of remission, consolidation, and maintenance therapy. Early response to remission-induced therapy is an important prognostic factor in ALL. This study aimed to assess the relationship between absolute neutrophil count (ANC) and bone marrow improvement after undergoing induction phase chemotherapy which was characterized by the occurrence of remission.
Methods: Acute Lymphoblastic Leukemia diagnosed based on CBC, peripheral smear, bone marrow morphology, and flow cytometry. Nineteen samples from children with Acute Lymphoblastic Leukemia were evaluated for blast count and absolute neutrophil count (ANC) on day 0, ANC on 3rd week, and blast count and ANC on the 6th week of remission induction therapy. We compared the results of outcomes after remission induction therapy.
Results: The ANC value at the 3rd week and 6th week of the chemotherapy phase was positively correlated with remission with the r=0.687 and with a p-value=0.001.
Conclusion: The trend of increasing ANC values was moderately positively correlated with the incidence of remission.