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The effect of black cumin seed oil consumption on the platelets and leukocytes number in healthy smokers in rural area Yogyakarta

  • Titiek Hidayati ,
  • Endang Darmawan ,
  • Indrayanti Indrayanti ,
  • Suny Sun ,


Background: The high number of smokers in rural areas is a public health problem in Indonesia. Tobacco smoke exposure is associated with the incidence of cardiovascular disease and cancer. Smoking increases the activity of the hematological system, characterized by an increase in the number of platelets and leukocytes. Platelet and leukocytes are essential cells in thrombus formation and hemostasis. As an immunomodulatory supplement, black cumin seed oil (BCSO) has been used in various studies, affecting the blood cell formation system. The purpose of the study was to determine the effect of administration of BCSO preparation for 30 days on platelet and leukocytes.

Methods: The 15 patients were placed into two groups in this open-label Randomized Controlled Trial. Group 1 received a placebo (3x1 capsules per day), and group 2 received BCSO (3x1 capsules per day). For 30 days, the intervention was carried out. Blood was obtained for analysis on the 31st day. The average amount of platelets and leukocytes in each group was compared using one-way ANOVA.

Results: The test results are said to have no difference in platelets and leukocytes number between groups with 30 days of BCSO consumption, with their respective values being 0.848 in the placebo group and 0.211 in the treatment group.

Conclusions: The homeostatic condition of subjects who consumed BCSO 3x2 capsules/day for 30 days remained stable and balanced.


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How to Cite

Hidayati, T., Darmawan, E., Indrayanti, I., & Sun, S. (2021). The effect of black cumin seed oil consumption on the platelets and leukocytes number in healthy smokers in rural area Yogyakarta. Bali Medical Journal, 10(3), 1146–1151.




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