Hematological profile of children under five years with typhoid fever at Idaman Banjarbaru Hospital, Indonesia

Harapan Parlindungan Ringoringo; Jun Rahmawati Surya Mentari; Roselina Panghiyangani; Edi Hartoyo; Rahmiati Lao

doi:10.15562/bmj.v11i2.2669

Hematological profile of children under five years with typhoid fever at Idaman Banjarbaru Hospital, Indonesia

Harapan Parlindungan Ringoringo ,

Jun Rahmawati Surya Mentari ,

Roselina Panghiyangani ,

Edi Hartoyo ,

Rahmiati Lao ,

pdf |
DOI: https://doi.org/10.15562/bmj.v11i2.2669 |
Published: 2022-07-30

Abstract

Introduction: Typhoid fever is a disease caused by Salmonella typhi, Salmonella paratyphi A, B, C. An estimated 200,000 people die each year from about 21.6 million people infected with typhoid fever. This study aims to determine the hematological profile in typhoid fever cases in children under five at Idaman Banjarbaru Hospital.

Methods: The research was carried out with a retrospective descriptive approach with a consecutive sampling technique. The research subjects were children under five diagnosed with typhoid fever recorded in the Idaman Banjarbaru Hospital's medical records for July 2018 to January 2019.

Results: The sample consisted of 58 patients, 32 boys, and 26 girls. Most patients were found in 12 - <36 months, namely 28 (48.28%) children. Thirty-eight (65.52%) children have a normal weight. The hematological profile showed that 46.55% of the patients had iron deficiency anemia (IDA). Hematocrit levels decreased in 51.72% of patients. Erythrocyte levels in 86.21% of patients were normal. Low MCV, low MCH, IDA were found in 46.55%, 36.21%, 46.55% of patients. Leukopenia was present in 17.24% of children. All patients had normal basophil values. Eosinopenia, band neutropenia, segmented neutropenia, lymphocytosis, monocytosis were found in 69.09%, 90.90%, 56.37%, 58.18%, 58.18% of children, respectively. Thrombocytopenia and thrombocytosis were found in the same percentage, 13.80%.

Conclusion: The haematological profile of typhoid fever patients in children under five can have different results depending on each child's body's response to S. typhi and S. paratyphi that enter the body.

References

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Wibawati R, Sudiwati NLPE, Maemunah N. GAMBARAN KLINIS PENDERITA DEMAM TIFOID DI RUANG ANAK RUMAH SAKIT UMUM DAERAH KOTABARU. Nurs News J Ilm Keperawatan. 2017;2(2).
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Qamar U. Hematological changes associated with typhoid fever Children’s Hospital and Institute of Child’s Healt. Rawal Med J. 2013;38(1):32-35.
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Dutta P, Nahrendorf M. Regulation and consequences of monocytosis. Immunol Rev. 2014;262(1):167-178. doi:10.1111/imr.12219
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[1] Sucipta A. Baku Emas Pemeriksaan Laboratorium Demam Tifoid pada Anak. J Skala Husada. 2015;12(1):22-26.

[2] Paul UK, Bandyopadhyay A. Typhoid fever: a review. Int J Adv Med. 2017;4(2):300. doi:10.18203/2349-3933.ijam20171035

[3] Wibawati R, Sudiwati NLPE, Maemunah N. GAMBARAN KLINIS PENDERITA DEMAM TIFOID DI RUANG ANAK RUMAH SAKIT UMUM DAERAH KOTABARU. Nurs News J Ilm Keperawatan. 2017;2(2).

[4] Ariati NN, Wiardani NK, Kusumajaya AAN, Supariasa IDN, Sidiartha L. Buku Saku Antropometri Gizi Anak PAUD. Inteligensia Media (Kelompok Penerbit Intrans Publishing); 2020. https://books.google.co.id/books?id=zTESEAAAQBAJ

[5] Ulfa F, Handayani OWK. Kejadian Demam Tifoid di Wilayah Kerja Puskesmas Pagiyanten. HIGEIA (Journal Public Heal Res Dev. 2018;2(2):227-238. doi:10.15294/higeia.v2i2.17900

[6] Alvarez M de la L, Wurgaft F, Espinoza J, Araya M, Figueroa G. Hygiene habits and carriers in families with a child who has had typhoid fever. Rev Saude Publica. 1992;26(2):75-81. doi:10.1590/S0034-89101992000200003

[7] Pether JVS, Scott RJD. Salmonella carriers; are they dangerous? A study to identify finger contamination with Salmonellae by convalescent carriers. J Infect. 1982;5(1):81-88. doi:10.1016/S0163-4453(82)93365-5

[8] Setiabudi D, Madiapermana K. Demam Tifoid pada Anak Usia di bawah 5 Tahun di Bagian Ilmu Kesehatan Anak RS Hasan Sadikin, Bandung. Sari Pediatr. 2016;7(1):9-14.

[9] Pramitasari OP. Faktor risiko kejadian penyakit demam tifoid pada penderita yang dirawat di rumah sakit umum daerah ungaran. J Kesehat Masy Univ Diponegoro. 2013;2(1):18787.

[10] Ramaningrum G, Anggraheny HD, Putri TP. Faktor-faktor yang Mempengaruhi Kejadian Demam Tifoid pada Anak di RSUD Tugurejo Semarang. J Kedokt Muhammadiyah. 2017;5(2).

[11] NP RA. Indeks RDW dan Mentzer sebagai Uji Skrining Diagnosis Thalassemia. J Major. 2015;4(7):7-12.

[12] Lestari R, Arguni E. Profil Klinis Anak dengan Demam Tifoid di Rumah Sakit Umum Pusat Dr Sardjito Yogyakarta. Sari Pediatr. 2017;19(3):139-144.

[13] Rosche KL, Aljasham AT, Kipfer JN, Piatkowski BT, Konjufca V. Infection with Salmonella enterica Serovar Typhimurium Leads to Increased Proportions of F4/80+ Red Pulp Macrophages and Decreased Proportions of B and T Lymphocytes in the Spleen. Moser M, ed. PLoS One. 2015;10(6):e0130092. doi:10.1371/journal.pone.0130092

[14] Srai SK, Sharp P. Proteins of Iron Homeostasis. In: Iron Physiology and Pathophysiology in Humans. Humana Press; 2012:3-25. doi:10.1007/978-1-60327-485-2_1

[15] Yildirim I, Ceyhan M, Bayrakci B, Uysal M, Kuskonmaz B, Ozaltin F. A Case Report of Thrombocytopenia-associated Multiple Organ Failure Secondary to Salmonella enterica Serotype Typhi Infection in a Pediatric Patient: Successful Treatment With Plasma Exchange. Ther Apher Dial. 2010;14(2):226-229. doi:10.1111/j.1744-9987.2009.00714.x

[16] Qamar U, Aijaz J. Haematological changes associated with typhoid fever. Rawal Med J. 2013;38(1):32-35.

[17] NAFIAH F, KHOIRIYAH RA, MUNIR M. DIAGNOSA DEMAM TIFOID DISERTAI KONDISI KADAR LEUKOSIT PASIEN DI RUMAH SAKIT ISLAM SAKINAH MOJOKERTO. KLOROFIL J Ilmu Biol dan Terap. 2017;1(1).

[18] Riza O. Gambaran jumlah leukosit dan trombosit pada pasien suspek demam tifoid di RSD dr M. Zein Painan [skripsi]. Published online 2019.

[19] Ishaq U, Malik J, Asif M, et al. Eosinopenia in Patients With Typhoid Fever: A Case-Control Study. Cureus. 2020;12(9). doi:10.7759/cureus.10359

[20] Tim penyusun pedoman interpretasi data klinik. Pedoman Interpretasi Data Klinik. Kementerian Kesehatan RI; 2011.

[21] Uplaonkar S V, Kauser SH, Tengli MB. Haematological profile in typhoid fever. Indian J Pathol Oncol. 2017;4(2):263-265. doi:10.18231/2394-6792.2017.0054

[22] Qamar U. Hematological changes associated with typhoid fever Children’s Hospital and Institute of Child’s Healt. Rawal Med J. 2013;38(1):32-35.

[23] Ifeanyi O. Changes in some haematological parameters in typhoid patients attending University Health Services Department of Michael Okpara University of Agriculture, Nigeria. InjJCurrMicrobiolAppSci. 2014;3(1):670-674.

[24] Dutta P, Nahrendorf M. Regulation and consequences of monocytosis. Immunol Rev. 2014;262(1):167-178. doi:10.1111/imr.12219

[25] AHMAD N, CHATTHA MN, NAYYAR ZA. Frequency of Thrombocytopenia in Children with Enteric Fever at PAF Hospital Sargodha. PJMHS. 2020;14(JAN MAR):632-633.

Hematological profile of children under five years with typhoid fever at Idaman Banjarbaru Hospital, Indonesia

Abstract

References

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