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Analysis of vitamin A level in leprosy patients


Background: Leprosy or Morbus Hansen is a contagious, chronic, and infectious disease mainly caused by Mycobacterium leprae (M. leprae), affecting the skin and peripheral nerves. Vitamin A is an essential non-enzymatic antioxidant for the body, which regulates various immune response components. A decline in the levels of vitamin A was discovered in leprosy. This study determined the levels of vitamin A and its comparison in multibacillary (MB) and paucibacillary (PB) type leprosy patients, also the relationship between vitamin A levels with bacterial index.

Method: This cross-sectional study included thirty-four leprosy patients, conducted at the Leprosy Division in Dermatology and Venereology Department of Haji Adam Malik General Hospital Medan, Pirngadi General Hospital Medan, Lau Simomo Leprosy Hospital, Sicanang Leprosy Hospital, and Belidahan Leprosy Hospital with consecutive sampling techniques from March to October 2018. We determined the levels of vitamin A and its comparison in multibacillary (MB) and paucibacillary (PB) type leprosy patients, also the relationship between vitamin A levels with bacterial index. A T test was then performed to compare vitamin A levels between PB and MB types of leprosy. The relationship between vitamin A levels and the bacterial index was tested using Pearson correlation.

Results: Most of these subjects were MB, male sex predominance, in 16-35 years with 21 subjects. The bacterial index of 0 can be found in 16 subjects (47.1%), +1 in 8 subjects (23.6%), +2 in as many as 5 subjects (14.7%), and +3 in 5 subjects (14.7%). The vitamin A level in MB type leprosy was lower than PB type leprosy (p = 0.001). We also found a negative correlation between vitamin A levels and the bacterial index in leprosy patients (r = -0.632, p = 0.000).

Conclusion: The higher the bacterial index value is, the lower the vitamin A level will be.


  1. Thorat D, Sharma P. Epidemiology. In: Kar K, Kumar B, editors. IAL Textbook of Leprosy. 1st ed. New Delhi: JPBMP; 2010. p. 24–43.
  2. Bryceson A, Pfaltzgraff R. Diagnosis. In: Bryceson A, Pfaltzgraff R, editors. Leprosy. 3rd ed. London: Churchil Livingstone; 1990. p. 57–76.
  3. Departemen Kesehatan RI Direktorat Jenderal Pengendalian Penyakit dan Penyehatan Lingkungan. Buku Pedoman Nasional Pemberantasan Penyakit Kusta. 18th ed. Departemen Kesehatan RI, editor. Jakarta: Departemen Kesehatan RI; 2007. 1–75 p.
  4. World Health Organization. Leprosy today [Internet]. 2016. Available from:
  5. Infodatin. Pusat Data dan Informasi Kementrian Kesehatan RI [Internet]. 2016. Available from:
  6. Kementerian Kesehatan Republik Indonesia. Profil Kesehatan Republik Indonesia tahun 2015 [Internet]. 2016. Available from:
  7. Pandya S, Sharma D, Sekar B, Porichha D, Mishra R, Kumar B. Leprosy. Indian Assoc Leprol. 2010;1:3–175.
  8. Vázquez CMP, Netto RSM, Barbosa KBF, de Moura TR, de Almeida RP, Duthie MS, et al. Micronutrients influencing the immune response in leprosy. Nutr Hosp. 2014;29(1):26–36.
  9. Goulart LR, Goulart IMB. Leprosy pathogenetic background: a review and lessons from other mycobacterial diseases. Arch Dermatol Res. 2008;301(2):123–37. Available from:
  10. Bartley J, Camargo C. Vitamin D and Infection. In: Vitamin D: Oxidative Stress, Immunity, and Aging. United States: CRC Press; 2013. p. 323–51.
  11. Amirudin M, Hakim Z, Darwis E. Diagnostik Penyakit Kusta. In: Daili E, Menaldi S, Ismiarto S, Nilasari H, editors. Kusta. 2nd ed. Jakarta: Balai Penerbit FK UI; 2003. p. 12–32.
  12. Eichelmann K, González González SE, Salas-Alanis JC, Ocampo-Candiani J. Leprosy. An Update: Definition, Pathogenesis, Classification, Diagnosis, and Treatment. Actas Dermo-Sifiliográficas (English Ed. 2013;104(7):554–63. Available from:
  13. Lastória JC, Abreu MAMM de. Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - part 1. An Bras Dermatol. 2014;89(2):205–18. Available from:
  14. Villamor E, Fawzi WW. Effects of vitamin a supplementation on immune responses and correlation with clinical outcomes. Clin Microbiol Rev. 2005;18(3):446–64. Available from:
  15. Stephensen CB. Vitamin A, Immunity, and Infection [Internet]. Nutrition, Immunity, and Infection. CRC Press; 2017. p. 181–96. Available from:
  16. Dawson HD, Li N-Q, DeCicco KL, Nibert JA, Ross AC. Chronic Marginal Vitamin A Status Reduces Natural Killer Cell Number and Function in Aging Lewis Rats. J Nutr. 1999;129(8):1510–7. Available from:

How to Cite

Dalimunthe, D. A., Hazlinda, C. P., & Partogi, D. (2021). Analysis of vitamin A level in leprosy patients. Bali Medical Journal, 10(2), 746–748.




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Dina Arwina Dalimunthe
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Cut Putri Hazlinda
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Donna Partogi
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