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Identification of the type of Human Papilloma Virus (HPV) in condyloma acuminata in the genital and/or anal areas in men who have sex with men (MSM)

  • Boy Ardi Rohanda ,
  • Richard Hutapea ,
  • Kristina Nadeak ,

Abstract

Background: Condyloma acuminata is a sexually transmitted infection (STI) caused by the Human Papilloma Virus (HPV), marked by mucosal and skin hyperplasia, especially in the anogenital areas. HPV is transmitted by sexual intercourse. The incidence of condyloma acuminata in men who sex with men (MSM) increases due to the variations in genito-anal sexual intercourse. This study determined the type of HPV in condyloma acuminata in the genital and/or anal area in MSM.

Methods: This study was a descriptive observational study with a cross sectional approach in 25 MSM subjects with condyloma acuminata at the Dermatology and Venereology outpatient clinic of Haji Adam Malik General Hospital Medan and Universitas Sumatera Utara Hospital from June 2020 to February 2021. Subjects were selected by consecutive sampling. The samples of condyloma acuminata were collected by a shave biopsy technique, followed by examining the DNA type of HPV using the PCR method. We collected the demographic data (age, education level, employment, condyloma acuminata location, and condyloma acuminata lesion shaped) and then presented it in the descriptive.

Results: From 25 men who had condyloma acuminata in this study, most of them (14 people or 56%) were 19-26 years old and unmarried with homosexual orientation. Fifteen people (60%) graduated from high school, and 21 respondents (84%) worked as employees. The most locations of condyloma acuminata on the anal area as many as 16 people (64%), the most common characteristic of the lesion was acuminatum, found in 16 people (64%), and the most common type of HPV was HPV type 11 in 13 people (52%). In the genital areas and anal areas, the most common type of HPV was HPV type 11 in 4 people (44,4%) and nine people (56,2%). The most characteristic lesions in the genital area were papule in 7 people (77,8%), and in the anal area were acuminatum in 14 people (87,5%).

Conclusion: The most common type of HPV in condyloma acuminata in the genital area and anal area in MSM were HPV type 11. The characteristic of condyloma acuminata lesions in the genital area in MSM was mostly papule, whereas in the anal area was acuminatum.

References

  1. Mayer KH, Carballo-Dieguez A. Homosexual and Bisexual Behavior in Men in Relation to STDs and HIV Infection. In: Holmes KK, Sparling PF, Stamm WE, Piot P, Wasserheit JN, Corey L, Cohen MS, Watts DH, editors. Sexually Transmitted Diseases. 4th edition. New York: McGraw-Hill; 2008.p.203-18.
  2. Wisnu MNM. Kondiloma akuminata perianal pada laki-laki yang berhubungan seksual dengan laki-laki yang terinfeksi human immunodeficiency virus. Laporan Kasus. Bali: Bagian Ilmu Kesehatan Kulit dan Kelamin Fakultas Kedokteran Universitas Udayana; 2016.
  3. Lin C, Lau JTF, Ho K, Lau MC, Tsui HY, Lo KK. Incidence of Genital Warts among the Hong Kong General Adult Population. BMC Infectious Diseases. 2010;10:272.
  4. Wilvestra S, Anum Q, Isramiarti. Perbedaan Tipe Human Papilloma Virus antara Human Immunodeficiency Virus Positif dan Negatif pada Pasien Kondiloma Akuminata Anogenital. Periodical of Dermatology and Venereology. 2019;31(2):131-137.
  5. Aswar A. Karakteristik Pasien Kondiloma Akuminata di RSUP Haji Adam Malik Medan Periode 1 Januari 2008-31 Desember 2011. Skripsi. Medan: Fakultas Kedokteran Universitas Sumatera Utara; 2012.
  6. Sitepu EEL. Karakteristik Pasien Kondiloma Akuminata pada Anogenital Dengan Human Immunodeficiency Virus (HIV) Di RSUP Haji Adam Malik Medan Periode Januari 2012 - Desember 2017. Tesis. Medan: Departemen Ilmu Kesehatan Kulit dan Kelamin FK USU; 2019.
  7. Rucitra CN. Proporsi Virus Papiloma Humanus Oral dan Hubungannya dengan Frekuensi Seks Oral pada Pasien Kondiloma Akuminatum Anogenital. Tesis. Jakarta: Program Pendidikan Dokter Spesialis Ilmu Kesehatan Kulit dan Kelamin FKUI; 2014.
  8. Patel H, Wagner M, Singhal P, Kothari S. Systematic review of the incidence and prevalence of genital warts. BMC. 2013;13:1-14.
  9. Indriatmi W, Zubier F. Kondiloma Akuminata. In: Daili SF, Nilasari H, Indriatmi W, Zubier F, Rowawi R, Pudjiati SR, editors. Infeksi Menular Seksual. 5th edition. Jakarta: Badan Penerbit Fakultas Kedokteran Universitas Indonesia; 2017.p.176-87.
  10. Oktaviyanti RN, Barakbah J. Profil Pasien Kondiloma Akuminata. Periodical of Dermatology and Venereology. 2018;30(3):240-7.
  11. Dietz CA, Nyberg CR. Genital, Oral, and Anal Human Papillomavirus Infection in Men who Have Sex with Men. J Am Osteopath Assoc. 2011; 111(3 suppl 2): S19-25.
  12. Kreimer A. Campbell CP, Lin, H. Incidence and clearance of oral human Papilloma virus infection in men: the HIM cohort. Lancet. 2013:3829895):877- 87.
  13. Sung J, Ahn, E, Oh H-K, et al. Association of immune status recument anal condyloma in human immunodeficiency virus positive paticnts. J Korean Soc Colproctol. 2012;28(6):294-8.
  14. Jeo WS, Sugiharto B, Kekalih A. Perianal Condyloma Acuminata: Factors that Contribute to the Recurrence. The New Ropansuri Journal of Surgery. 2018;3(2):31–3.
  15. Dhumale SB, Sharma S, Gulbake A. Ano-Genital Warts and HIV Status– A Clinical Study. Journal of Clinical and Diagnostic Research. 2017;11(1):1-4.
  16. Saputra N. Karakteristik Kejadian Kasus Kondiloma Akuminata di Indonesia. Muhammadiyah Journal. 2020;1(1):25.
  17. Wahyuni CU. Faktor-faktor yang Mempengaruhi Terjadinya Infeksi HPV 16/18. Tesis. Surabaya : Program Pascasarjana Universitas Airlangga; 2002.
  18. Effendi A, Silvia E, Hernisa MP. Analisis Faktor-faktor yang Berhubungan dengan Kondiloma Akuminata Di Poliklinik Kulit dan Kelamin RSUD Dr. H. Abdul Moeloek Bandar Lampung Tahun 2016. Jurnal Ilmu Kedokteran Dan Kesehatan. 2017;4(1):8-11.
  19. Sulistyaningrum S. Identifikasi Tipe Human Papilomavirus pada Berbagai Bentuk Klinis Kondiloma Akuminatum di Poliklinik Kulit dan Kelamin RSUPN Dr. Ciptomangunkusumo. Tesis. Jakarta: Program Pendidikan Dokter Spesialias Departemen Ilmu Kesehatan Kulit dan Kelamin FKUI. 2013.
  20. Ali KBM, Abdul-jabbar M, Al-Soudani A, Ismail AS. Clinical and epidemiological patterns of ano-genital warts among male patients in Erbil city, Iraq. Annals of the College of Medicine. 2012;38(2):28-34.
  21. Giuliano AR, Tortolero-Luna G, Ferrer E, Burchell AN, de Sanjose S, Kjaer SK, et al. Epidemiology of Human Papillomavirus Infection in Men, in Cancers other than Cervical and in Benign Conditions. Vaccine. 2008;26(10).
  22. Cong X, Sun R, Zhang X, Wang Y, Wang L, Yu Y. Correlation of human papillomavirus types with clinical features of patients with condyloma acuminatum in China. International Journal of Dermatology. 2016;55(7):775– 80.
  23. Che YM, Wang JB, Liu YH. Correlation between deoxyribonucleic acid loads of human papillomavirus and recurrence of condylomata acuminata. Int J STD AIDS. 2005;16:605-7.
  24. Woodman CB, Collins S, Winter H, Bailey A, Ellis J, Prior P, et al. Natural history of cervical human papillomavirus infection in young women: a longitudinal cohort study. Lancet. 2001;357:1831-6.
  25. Leung AKC, Barankin B, Leong KF, Hon KL. Penile warts: An update on their evaluation and management. Drugs Context. 2018;7:1–14.
  26. Florez-Diaz E, Sereday KA, Ferreira S, Sirak B, Sobrinho JS, Baggio ML, et al. HPV-11 variability, persistence and progression to genital warts in men: The HIM study. Journal of General Virology. 2017;98(9):2339–42.
  27. Koefoed K, Sand C, Forslund O, et al. Prevalence of human papillomavirus anal and oral site among patients with genital warts. Acta Derm Venereol. 2013:94:15.
  28. Leszczyszyn J, Lebski I, Lysenko L, Hirnle L, Gerber H. Anal warts (Condylomata Acuminata) - Current issues and treatment modalities. Adv Clin Exp Med. 2014;23(2):307–11.
  29. Anum Q, Lestari S, Hasriningrum TP, Putri EK. Manifestasi klinis kutil kelamin pada pasien poliklinik kulit dan kelamin RS dr. M. Djamil Padang. Mdvi. 2016;42:89-93.
  30. Wiraguna AAGP, Puspawati NMD. Condyloma acuminatum in a 62-year-old patient with HIV infection. Bali Med J. 2020;9(1):91-4.
  31. Ratnasari DT. Kondiloma Akuminata. Ilmiah Kedokteran Wijaya Kusuma. 2018;5(2):18–21.
  32. Hastuti R, Mustifah EF, Ellistasari EY. Kombinasi Krioterapi dan KOH 5% untuk Terapi Kondiloma Akuminata Raksasa dengan Infeksi HIV. 2018;45(7):524–7.
  33. Na K, Sung JY, Kim HS. Clinicopathological Characteristics of High-grade Squamous Intraepithelial Lesions Involving Condyloma Acuminatum. Anticancer Research. 2018;38(3):1767-74.
  34. Chan MP. Verruciform and condyloma-like squamous proliferations in the Anogenital Region. Arch Pathol Lab Med. 2019:1-11.
  35. Niode NJ, Oroh EEC, Warouw WFT, Daili SF. Kondiloma Akuminata Raksasa pada Pasien AIDS. Media Dermato-Venereologica Indosiana. 2012;165-8.

How to Cite

Rohanda, B. A., Hutapea, R., & Nadeak, K. (2021). Identification of the type of Human Papilloma Virus (HPV) in condyloma acuminata in the genital and/or anal areas in men who have sex with men (MSM). Bali Medical Journal, 10(2), 885–890. https://doi.org/10.15562/bmj.v10i2.2439

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