WHO estimates that as many as 300 to 500 million people are infected with malaria each year. There are around 3 million severe malaria cases (complicated malaria) and deaths due to malaria. Other sources revealed that as many as 1.5 million to 2.7 million people die every year, especially children and pregnant women. Malaria is a disease that is emerging and continues to affect the people of Aceh. Malaria in pregnancy is a serious problem considering its effects on the mother and fetus, which can increase maternal and neonatal mortality rates if not treated quickly and accurately. Prevention of malaria in pregnancy can be started early through ANC visits by providing health education about malaria prevention and prophylactic treatment for those living in endemic areas. The purpose of this review is to discuss the classification of the Aceh Province according to the level of susceptibility to malaria was based on the API value criteria, to discuss prompt treatment of malaria will improve maternal and fetal outcomes.