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The dynamic of Soluble Vascular Cellular Adhesion Molecule -1 (sVCAM-1) level in Overnutritious children with Dengue Infection

Abstract

Introduction: Dengue infection is still posed a significant medical challenge for pediatric population in developing countries. However, increased prevalence of overweight and obesity among children in those countries increased the possibility of the coexistence of these conditions. However, their interaction is still under investigated. Therefore, this study was aimed to study the dynamic of sVCAM-1 level as the known predictor of the severity of dengue infection with over nutritional status in children with dengue infection.

Method: An analytic observational nested case-control study was conducted in Paediatric Division Sanglah General Hospital, Bali. The children with DHF between 6 months old to 12 years old were included as the case group while control groups consisted of pediatric patients with just Dengue Fever (DF) with the same age range. The diagnosis of dengue was established using 1997 WHO criteria while nutritional status was assessed using WHO curve. The sVCAM-1 was evaluated using ELISA technique.

Results: The level of sVCAM-1 was significantly higher in patients with DHF than patients with DF only. The level was also fluctuated more in DHF patients. Likewise, the sVCAM-1 level was also significantly higher in DHF patients with overnutrition compared to normal DHF patients with a more fluctuated pattern over the course of 3 days (starting from day 4 to day 7). Finally, no significant finding was observed in sVCAM-1 level in DSS patients albeit the difference in concentration pattern.

Conclusion: Overnutrition is seems to be associated with higher concentration of sVCAM-1 and higher fluctuation of its concentration in children with DHF.

References

  1. Utama IMS, Lukman N, Sukmawati DD, et al. Dengue viral infection in Indonesia: Epidemiology, diagnostic challenges, and mutations from an observational cohort study. PLoS Negl Trop Dis. 2019;13(10):e0007785. https://doi.org/10.1371/journal.pntd.0007785
  2. Zulkipli MS, Dahlui M, Jamil N, et al. The association between obesity and dengue severity among pediatric patients: A systematic review and meta-analysis. PLoS Negl Trop Dis. 2018;12(2):e0006263-e0006263. doi:10.1371/journal.pntd.0006263
  3. Trang NTH, Long NP, Hue TTM, et al. Association between nutritional status and dengue infection: a systematic review and meta-analysis. BMC Infect Dis. 2016;16:172. doi:10.1186/s12879-016-1498-y
  4. Pichainarong N, Mongkalangoon N, Kalayanarooj S, Chaveepojnkamjorn W. Relationship between body size and severity of dengue hemorrhagic fever among children aged 0-14 years. Southeast Asian J Trop Med Public Health. 2006;37(2):283-288.
  5. Mazidi M, Banach M, Kengne AP, Group L and BPMC. Prevalence of childhood and adolescent overweight and obesity in Asian countries: a systematic review and meta-analysis. Arch Med Sci. 2018;14(6):1185-1203. doi:10.5114/aoms.2018.79001
  6. Mistry SK, Puthussery S. Risk factors of overweight and obesity in childhood and adolescence in South Asian countries: a systematic review of the evidence. Public Health. 2015;129(3):200-209. doi:10.1016/j.puhe.2014.12.004
  7. Reilly SM, Saltiel AR. Adapting to obesity with adipose tissue inflammation. Nat Rev Endocrinol. 2017;13(11):633-643. doi:10.1038/nrendo.2017.90
  8. Ellulu MS, Patimah I, Khaza’ai H, Rahmat A, Abed Y. Obesity and inflammation: the linking mechanism and the complications. Arch Med Sci. 2017;13(4):851-863. doi:10.5114/aoms.2016.58928
  9. Saniathi NKE, Rianto BUD, Juffrie M, . S. The Effect of Overnutrition Toward the Risk of Dengue Shock Syndrome in Pediatric Patient: In-Depth Investigation of sVCAM-1 and Adiponectin Level. Bali Med Journal; Vol 7, No 1 (Available online 1 April 2018). Published online 2018. https://www.balimedicaljournal.org/index.php/bmj/article/view/912
  10. Elmy Saniathi NK, Djoko Rianto BU, Juffrie M, Soetjiningsih S. Dengue hemorrhagic fever: The role of Soluble E-Selektin, Soluble Intra Cellular Adhesion Molecule-1 (Sicam-1) and Soluble Vascular Cellular Adhesion Molecule -1 (Svcam-1) in overweight children. Bali Med Journal; Vol 8, No 1 (Available online 1 April 2019). Published online 2018. https://www.balimedicaljournal.org/index.php/bmj/article/view/1289
  11. Harapan H, Michie A, Mudatsir M, Sasmono RT, Imrie A. Epidemiology of dengue hemorrhagic fever in Indonesia: analysis of five decades data from the National Disease Surveillance. BMC Res Notes. 2019;12(1):350. doi:10.1186/s13104-019-4379-9
  12. de Heredia FP, Gómez-Martínez S, Marcos A. Obesity, inflammation and the immune system. Proc Nutr Soc. 2012;71(2):332-338. doi:10.1017/S0029665112000092
  13. Ruiz LD, Zuelch ML, Dimitratos SM, Scherr RE. Adolescent Obesity: Diet Quality, Psychosocial Health, and Cardiometabolic Risk Factors. Nutrients. 2019;12(1):43. doi:10.3390/nu12010043
  14. Bhatt P, Sabeena SP, Varma M, Arunkumar G. Current Understanding of the Pathogenesis of Dengue Virus Infection. Curr Microbiol. 2021;78(1):17-32. doi:10.1007/s00284-020-02284-w
  15. Martina BEE, Koraka P, Osterhaus ADME. Dengue Virus Pathogenesis: an Integrated View. Clin Microbiol Rev. 2009;22(4):564 LP - 581. doi:10.1128/CMR.00035-09

How to Cite

Elmy Saniathi, N. K., Juffrie, M., Rianto, B. U. D., & Soetjiningsih, S. (2021). The dynamic of Soluble Vascular Cellular Adhesion Molecule -1 (sVCAM-1) level in Overnutritious children with Dengue Infection. Bali Medical Journal, 10(1), 261–265. https://doi.org/10.15562/bmj.v10i1.2304

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Ni Kadek Elmy Saniathi
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Mohammad Juffrie
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Bambang Udji Djoko Rianto
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Soetjiningsih Soetjiningsih
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