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Primary infertility of male and female factors, polycystic ovary syndrome and oligoasthenoteratozoospermia dominate the infertile population in agricultural and industrial areas in Karawang Regency, West Java Province, Indonesia

Abstract

Introduction: Indonesia is a country with a large agricultural and industry, known to utilize various types of pesticides, as well as several other industries with uncontrolled pollution levels distributed across the nation. Besides, numerous studies have stated the adverse effects of chemicals substances used in daily life and industrial waste on the health of living things, including humans. This study aimed to determine the infertility characteristic in the agricultural and industrial areas in Karawang Regency, West Java Province, Indonesia.

Methods: The study was conducted retrospectively on medical records. Therefore, this study determined the infertility characteristics based on sperm analysis, the etiology of the causes of infertility in female, and the diagnosis of infertility. Data collection was obtained from patients' medical records in the Infertile Poly of Mitra Bunda Amanda Hospital Karawang, Karawang Regency, West Java Province, Indonesia. 

Result: The results showed infertility was most prevalent in males aged 30-40 years (55.79%) and females below 30 years (61.05%). Furthermore, the male and female's most prevalent educational qualification (33.68% and 36.84%, respectively) was discovered to be high school diploma. In terms of occupation, most male (56.84%) were laborers, while the female was mostly housewives (36.84%). Meanwhile, oligoasthenoteratozoospermia was the most analyzed sperm type (33.68%), and polycystic ovary syndrome was the most common etiology of infertility in females (26.32%). The most prevalent diagnosis was primary infertility factors, male and female (45.26%).

Conclusion: Primary infertility of male and female factors, polycystic ovary syndrome and oligoasthenoteratozoospermia dominate the infertile population in agricultural and industrial areas in Karawang Regency, West Java Province, Indonesia.

References

  1. Kelishadi R. Environmental pollution: health effects and operational implications for pollutants removal. J Environ Public Health. 2012;2012:341637. Available from: https://pubmed.ncbi.nlm.nih.gov/22619687
  2. Park SK, Tao Y, Meeker JD, Harlow SD, Mukherjee B. Environmental risk score as a new tool to examine multi-pollutants in epidemiologic research: an example from the NHANES study using serum lipid levels. PLoS One. 2014;9(6):e98632–e98632. Available from: https://pubmed.ncbi.nlm.nih.gov/24901996
  3. Joffe M. Infertility and environmental pollutants. Br Med Bull. 2003;68(1):47–70. Available from: http://dx.doi.org/10.1093/bmb/ldg025
  4. Lin S-Y, Yang Y-C, Chang CY-Y, Lin C-C, Hsu W-H, Ju S-W, et al. Risk of Polycystic Ovary Syndrome in Women Exposed to Fine Air Pollutants and Acidic Gases: A Nationwide Cohort Analysis. Int J Environ Res Public Health. 2019;16(23):4816. Available from: https://pubmed.ncbi.nlm.nih.gov/31801197
  5. Huang C, Tang M, Li H, Wen J, Wang C, Gao Y, et al. Particulate matter air pollution and reduced heart rate variability: How the associations vary by particle size in Shanghai, China. Ecotoxicol Environ Saf. 2021;208:111726. Available from: http://dx.doi.org/10.1016/j.ecoenv.2020.111726
  6. Kirkley AG, Sargis RM. Environmental endocrine disruption of energy metabolism and cardiovascular risk. Curr Diab Rep. 2014;14(6):494. Available from: https://pubmed.ncbi.nlm.nih.gov/24756343
  7. Parwanto MLE, Mediana D, Samara D, Wartono M, Pakpahan A, Widyatama HG. Aortic enlargement: a case report of cadaveric heart and great vessels dimensions. Bali Med J. 2020;9(2):416. Available from: http://dx.doi.org/10.15562/bmj.v9i2.1817
  8. Mahalingaiah S, Sun F, Cheng JJ, Chow ET, Lunetta KL, Murabito JM. Cardiovascular risk factors among women with self-reported infertility. Fertil Res Pract. 2017;3:7. Available from: https://pubmed.ncbi.nlm.nih.gov/28620545
  9. Rignell-Hydbom A, Rylander L, Giwercman A, Jönsson BAG, Lindh C, Eleuteri P, et al. Exposure to PCBs and p,p’-DDE and human sperm chromatin integrity. Environ Health Perspect. 2005;113(2):175–9. Available from: https://pubmed.ncbi.nlm.nih.gov/15687046
  10. Sholeh M, Pranoto P, Budiastuti S, Sutarno S. Analysis of Citarum River pollution indicator using chemical, physical, and bacteriological methods [Internet]. Author(s); 2018. Available from: http://dx.doi.org/10.1063/1.5082473
  11. Utami AW, Purwaningrum P, Hendrawan DI. The Pollutant Load in Downstream Segment of Citarum River, Indonesia. Int J Sci Technol Res. 2020;9(01):3506–10. Available from: http://www.ijstr.org/final-print/jan2020/The-Pollutant-Load-In-Downstream-Segment-Of-Citarum-River-Indonesia.pdf
  12. Kushner PJ, Webb P, Uht RM, Liu M-M, Price RH. Estrogen receptor action through target genes with classical and alternative response elements. Pure Appl Chem. 2003;75(11–12):1757–69. Available from: http://dx.doi.org/10.1351/pac200375111757
  13. Carré J, Gatimel N, Moreau J, Parinaud J, Léandri R. Does air pollution play a role in infertility?: a systematic review. Environ Health. 2017;16(1):82. Available from: https://pubmed.ncbi.nlm.nih.gov/28754128
  14. Yan Y, Lu XS, Li DL, Yu YJ. Effects of environmental lead pollution on blood lead and sex hormone levels among occupationally exposed group in an E-waste dismantling area. Biomed Environ Sci. 2013;26(6):474–84.
  15. https://europepmc.org/article/med/23816581.
  16. Toson EA, Elagamey AG, El Morsi ZI, El Razek SYA and Eldahtory FA. Effects of pollution on Chromosomes: Correlation with Infertility and Sex Hormones levels. Damietta University
  17. Accessed on http: file:///C:/Users/User/Downloads/1%20(1).pdf, Januari 14th, 2021 10.08 Western Indonesian Time
  18. Pepine CJ, Park K. Fertility Therapy and Long-Term Cardiovascular Risk. J Am Coll Cardiol. 2017;70(10):1214–5. Available from: http://dx.doi.org/10.1016/j.jacc.2017.07.731
  19. Harzif AK, Santawi VPA, Wijaya S. Discrepancy in perception of infertility and attitude towards treatment options: Indonesian urban and rural area. Reprod Health. 2019;16(1):126. Available from: https://pubmed.ncbi.nlm.nih.gov/31426818
  20. Logan S, Gu R, Li W, Xiao S, Anazodo A. Infertility in China: Culture, society and a need for fertility counselling. Asian Pacific J Reprod. 2019;8(1):1. Available from: http://dx.doi.org/10.4103/2305-0500.250416
  21. Hamilton TRDS, Mendes CM, de Castro LS, de Assis PM, Siqueira AFP, Delgado J de C, et al. Evaluation of Lasting Effects of Heat Stress on Sperm Profile and Oxidative Status of Ram Semen and Epididymal Sperm. Oxid Med Cell Longev. 2016/01/17. 2016;2016:1687657. Available from: https://pubmed.ncbi.nlm.nih.gov/26881013
  22. Rose JJ, Wang L, Xu Q, McTiernan CF, Shiva S, Tejero J, et al. Carbon Monoxide Poisoning: Pathogenesis, Management, and Future Directions of Therapy. Am J Respir Crit Care Med. 2017;195(5):596–606. Available from: https://pubmed.ncbi.nlm.nih.gov/27753502
  23. Mendola P, Messer LC, Rappazzo K. Science linking environmental contaminant exposures with fertility and reproductive health impacts in the adult female. Fertil Steril. 2008;89(2):e81–94. Available from: http://dx.doi.org/10.1016/j.fertnstert.2007.12.036
  24. Kementerian Perindustrian Republik Indonesia. PEDOMAN TEKNIS KAWASAN INDUSTRI [Internet]. 35/M-IND/PER/3/2010 Indonesia; 2010. Available from: https://peraturan.bkpm.go.id/jdih/userfiles/batang/permen_deprin_35_2010.pdf
  25. Hamilton KJ, Hewitt SC, Arao Y, Korach KS. Estrogen Hormone Biology. Curr Top Dev Biol. 2017/02/03. 2017;125:109–46. Available from: https://pubmed.ncbi.nlm.nih.gov/28527569
  26. Golub MS. Effects of Exogenous Estrogenic Agents on Pubertal Growth and Reproductive System Maturation in Female Rhesus Monkeys. Toxicol Sci. 2003;74(1):103–13. Available from: http://dx.doi.org/10.1093/toxsci/kfg090
  27. Rajapakse N, Silva E, Kortenkamp A. Combining xenoestrogens at levels below individual no-observed-effect concentrations dramatically enhances steroid hormone action. Environ Health Perspect. 2002;110(9):917–21. Available from: https://pubmed.ncbi.nlm.nih.gov/12204827
  28. Guyansyah A, Parwanto MLE. Protein pengikat hormon seks: sex hormone binding globulin (SHBG) dan aksi steroid seks. J Biomedika dan Kesehat. 2019;2(1):45–50. Available from: http://dx.doi.org/10.18051/jbiomedkes.2019.v2.45-50
  29. Boeri L, Capogrosso P, Cazzaniga W, Pozzi E, Candela L, Belladelli F, et al. SHBG levels in primary infertile men: a critical interpretation in clinical practice. Endocr Connect. 2020;9(7):658–66. Available from: https://pubmed.ncbi.nlm.nih.gov/32520727
  30. Parwanto MLE. The negative correlation between testosterone levels and age in healthy Indonesian men residing in the special capital province of Jakarta, Indonesia. Int J Res Med Sci. 2017;5(8):3431. Available from: http://dx.doi.org/10.18203/2320-6012.ijrms20173535
  31. Suweino, Parwanto MLE, Tjahjadi D. Low testosterone level increases fasting blood glucose level in adult males. Univ Med. 2012, 13(3):200-207. Available from:
  32. https://univmed.org/ejurnal/index.php/medicina/article/view/87.
  33. Parwanto ML, Suweino S, Tjahjadi D, Senjaya H, Edy H, Pakpahan A. The effect of sex hormone-binding globulin (SHBG) protein polymorphism on the levels of SHBG, testosterone, and insulin in healthy Indonesian men. Int J Med Sci Public Heal. 2016;5(4):799. Available from: http://dx.doi.org/10.5455/ijmsph.2016.17122015293
  34. Parwanto MLE, Indrawati Y, Setiawan H. Isoflavone supplementation reduced serum sex hormone binding globulin concentration in postmenopausal women. Univ Med. 2012, 31 (1):52-62. Available from:
  35. https://univmed.org/ejurnal/index.php/medicina/article/view/113/0.
  36. Parwanto MLE, Senjaya H. Dietary intake of mother in childbearing age with BMI <18.5 kg/m2 and has heterozygous variant D327N SHBG genotype (w/v). Int J Community Med Public Health. 2017, 4(2):409-417. Available from: http://www.ijcmph.com. doi: http://dx.doi.org/10.18203/2394-6040.ijcmph20170264
  37. Parwanto MLE. The genetic aspect and morphological appearance of achondrogenesis. Int J Reprod Contraception, Obstet Gynecol. 2017;6(8):3203. Available from: http://dx.doi.org/10.18203/2320-1770.ijrcog20173146
  38. Parwanto MLE. Rare defect at superior helix as morphological variation of right auricle. Int J Res Med Sci. 2018;6(5):1800. Available from: http://dx.doi.org/10.18203/2320-6012.ijrms20181780
  39. Parwanto MLE, Mahyunis, Senjaya H, Edy HJ, Syamsurizal. Fractionation and characterization of proteins in Lumbricus rubellus powders. IJPCR. 2016, 8(1):15-21. Available online at www.ijpcr.com.
  40. Wolf WM, Wattick RA, Kinkade ON, Olfert MD. Geographical Prevalence of Polycystic Ovary Syndrome as Determined by Region and Race/Ethnicity. Int J Environ Res Public Health. 2018;15(11):2589. Available from: https://pubmed.ncbi.nlm.nih.gov/30463276
  41. Okoroh EM, Hooper WC, Atrash HK, Yusuf HR, Boulet SL. Prevalence of polycystic ovary syndrome among the privately insured, United States, 2003-2008. Am J Obstet Gynecol. 2012;207(4):299.e1-299.e7. Available from: http://dx.doi.org/10.1016/j.ajog.2012.07.023
  42. Kshetrimayum C, Sharma A, Mishra VV, Kumar S. Polycystic ovarian syndrome: Environmental/occupational, lifestyle factors; an overview. J Turkish Ger Gynecol Assoc. 2019/03/01. 2019;20(4):255–63. Available from: https://pubmed.ncbi.nlm.nih.gov/30821135
  43. Merkin SS, Phy JL, Sites CK, Yang D. Environmental determinants of polycystic ovary syndrome. Fertil Steril. 2016;106(1):16–24. Available from: http://dx.doi.org/10.1016/j.fertnstert.2016.05.011
  44. Matuszczak E, Komarowska MD, Debek W, Hermanowicz A. The Impact of Bisphenol A on Fertility, Reproductive System, and Development: A Review of the Literature. Int J Endocrinol. 2019;2019:4068717. Available from: https://pubmed.ncbi.nlm.nih.gov/31093279
  45. Rashtian J, Chavkin DE, Merhi Z. Water and soil pollution as determinant of water and food quality/contamination and its impact on female fertility. Reprod Biol Endocrinol. 2019;17(1):5. Available from: https://pubmed.ncbi.nlm.nih.gov/30636624
  46. Kandaraki E, Chatzigeorgiou A, Livadas S, Palioura E, Economou F, Koutsilieris M, et al. Endocrine Disruptors and Polycystic Ovary Syndrome (PCOS): Elevated Serum Levels of Bisphenol A in Women with PCOS. J Clin Endocrinol Metab. 2011;96(3):E480–4. Available from: http://dx.doi.org/10.1210/jc.2010-1658
  47. Toragall MM, Satapathy SK, Kadadevaru GG, Hiremath MB. Evaluation of Seminal Fructose and Citric Acid Levels in Men with Fertility Problem. J Hum Reprod Sci. 2019;12(3):199–203. Available from: https://pubmed.ncbi.nlm.nih.gov/31576076

How to Cite

Guyansyah, A., Wratsangka, R., Dhanardono, D., Ghazali, M. F., Edy, H. J., Widyatama, H. G., Kusumaningrum, D., Tjahyadi, D., & Parwanto, E. (2021). Primary infertility of male and female factors, polycystic ovary syndrome and oligoasthenoteratozoospermia dominate the infertile population in agricultural and industrial areas in Karawang Regency, West Java Province, Indonesia. Bali Medical Journal, 10(1), 167–173. https://doi.org/10.15562/bmj.v10i1.2281

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Assangga Guyansyah
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Raditya Wratsangka
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Denny Dhanardono
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Muhammad Farid Ghazali
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