Skip to main content Skip to main navigation menu Skip to site footer

Maternal and perinatal outcomes with covid-19: lesson learned from the tertiary hospital

  • Putri Sekar Wiyati ,
  • Rabiah Adawiyah ,
  • Julian Dewantiningrum ,
  • Besari Adi Pramono ,


Background: The COVID-19 pandemic has led to global health crisis. Most studies have focused on evaluating the effects of COVID-19 on the general population, and there is still insufficient data on its impact on vulnerable populations, such as pregnant women. The study evaluates maternal and perinatal outcomes on pregnant women with COVID-19 in Kariadi as tertiary hospital in Central Java.

Methods: We prospectively collected and analyzed data for a cohort of 45 pregnant patients with COVID-19 between March 31st and September 23th 2020 in Kariadi hospital.

Results: A total of 45 pregnant women with COVID-19 delivered 46 babies including one twin pregnancy. The symptoms ranged from asymptomatic (54.3%), mild (26.6%), moderate (8.8%), severe (2.2%), and critical (6.6%). Gestational age was 22 to 41 weeks. Cesarean section was the most mode of delivery (86.7 %). Diabetes in pregnancy and HIV were the most common comorbidities found in this study, there were also seven patients came with preeclampsia. There were three maternal mortalities, we reported one maternal death (2.2 %) caused by severe respiratory disease COVID-19 in second trimester. The other two death cases were pregnancy complicated with severe preeclampsia with hyperthyroid and preeclampsia with diabetes in pregnancy.  Perinatal outcomes were intrauterine fetal death (8.7%), stillbirth (2.2%), and severe asphyxia (2.2%).

Conclusion: Although we obtain mostly maternal and perinatal outcomes in good outcomes, it is urgent to analyze potential high-risk maternal death with COVID 19.


  1. Antoun L, Taweel N, El AI, Patni S, Honest H. Maternal COVID-19 infection, clinical characteristics, pregnancy, and neonatal outcome: A prospective cohort study. Eur J Obstet Gynecol Reprod Biol. 2020;252:559–562.
  2. Vannabouathong C, Devji T, Ekhtiari S, Chang Y, Phillips SA, Zhu M, Chagla Z, Main C, Bhandari M. Novel Coronavirus COVID-19: Current Evidence and Evolving Strategies. J Bone Joint Surg Am. 2020;102(9):734-744. doi: 10.2106/JBJS.20.00396.
  3. Indonesian Obstetrics and Gynecology Society. Recommendations for Handling Corona Virus Infection (Covid-19) in Maternal (Pregnancy, Childbirth and Postpartum); 2020.
  4. Savasi VM, et al. Clinical findings and disease severity in hospitalized pregnant women with coronavirus disease 2019 (COVID-19). Obstet Gynecol. 2020;136:252–258.
  5. Juan J, et al. Effect of coronavirus disease 2019 (COVID-19) on maternal, perinatal and neonatal outcome: systematic review. Ultrasound in Obstetrics and Gynecology. 2020;56:15–27.
  6. Zaigham M, Andersson O. Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies. Acta Obstetricia et Gynecologica Scandinavica. 2002;99:823–829.
  7. Hantoushzadeh S, et al. Maternal death due to COVID-19. Am J Obstet Gynecol. 2020;223:109.e1-109.e16.
  8. Khoury R, et al. Characteristics and outcomes of 241 births to women with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection at Five New York City Medical Centers. Obstet Gynecol. 2020;136:273–282.
  9. Poon LC, et al. Global interim guidance on coronavirus disease 2019 (COVID-19) during pregnancy and puerperium from FIGO and allied partners: Information for healthcare professionals. Int J Gynecol Obstet. 2020;149:273–286.
  10. Guan WJ, Chen RC, Zhong NS. Strategies for the prevention and management of coronavirus disease 2019. Eur Respir J. 2020;55(4):2000597. doi: 10.1183/13993003.00597-2020.
  11. Smith V, Seo D, Warty R, Payne O, Salih M, Chin KL, Ofori-Asenso R, Krishnan S, da Silva Costa F, Vollenhoven B, Wallace E. Maternal and neonatal outcomes associated with COVID-19 infection: A systematic review. PLoS One. 2020;15(6):e0234187. doi: 10.1371/journal.pone.0234187.
  12. Di Mascio D, Khalil A, Saccone G, Rizzo G, Buca D, Liberati M, Vecchiet J, Nappi L, Scambia G, Berghella V, D'Antonio F. Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. Am J Obstet Gynecol MFM. 2020;2(2):100107. doi: 10.1016/j.ajogmf.2020.100107.

How to Cite

Wiyati, P. S., Adawiyah, R., Dewantiningrum, J., & Pramono, B. A. (2021). Maternal and perinatal outcomes with covid-19: lesson learned from the tertiary hospital. Bali Medical Journal, 10(1), 442–447.




Search Panel

Putri Sekar Wiyati
Google Scholar
BMJ Journal

Rabiah Adawiyah
Google Scholar
BMJ Journal

Julian Dewantiningrum
Google Scholar
BMJ Journal

Besari Adi Pramono
Google Scholar
BMJ Journal