Background: Skin tags (known as acrochordon) are the most common benign skin tumors, usually skin-colored or hyperpigmented, found in the natural folds of the skin. They have been associated with various clinical conditions. A few studies results have been reported regarding the oxidative stress are strongly associated with skin tumor. Malondialdehyde (MDA) is an end product of lipid peroxidation by free radicals in the body. MDA assay is widely used as a biomarker to evaluate systemic oxidative stress in biomedical fields. This study evaluated the difference in serum MDA level in skin tags patients and control
Methods: This study is an analytic observational study with a cross-sectional design, including 40 patients with skin tags and 40 healthy volunteer controls, based on inclusion and exclusion criteria. Age, sex, and family history of skin tags were estimated on the patients. Diagnosis of skin tags was made based on history and clinical examination. Measurement of MDA level by enzyme-linked immunosorbent assay (ELISA) to the patients and controls. Mann- Whitney test is used to determine the differences in serum MDA levels. The results were significant, with a p-value <0.05.
Results: Mean MDA level of skin tags patients was highest at age 50â€“ 59 years (27,01 Â± 10,87 nmol/ml). The mean MDA level of male skin tag patients (15,99 Â± 8,23 nmol/ml) was higher than females (15,23 Â± 8,17 nmol/ml). The mean MDA level of skin tag patients with a family history (19,77Â± 7,92 nmol/ml) was higher compared to patients without a family history (11,82 Â± 8,48 nmol/ml). The mean of MDA level was significantly higher in the skin tags group (15,81 Â± 8,23 nmol/ml) than the control group (8,86Â± 7,02ng/ml) with p = 0.032.
Conclusion: There were higher significant differences in serum MDA levels in the skin tags patients than in control.