Skip to main content Skip to main navigation menu Skip to site footer

Lower facial skin hydration level increases acne vulgaris severity level

  • Maya Oktari Yolanda ,
  • Nelva Karmila Jusuf ,
  • Imam Budi Putra ,

Abstract

Backgrounds: Acne vulgaris is a chronic sebaceous gland inflammatory disorder that predominantly affects adolescents and young adults. Increased sebum, alterations in follicular keratinization, Cutibacterium acnes colonization, and inflammation are the critical pathways in the pathogenesis of acne vulgaris. Facial skin hydration can affect the primary pathogenesis mechanism of acne vulgaris. This study aimed to examine the correlation between the level of facial skin hydration and the severity of acne vulgaris.

Methods: This study was an observational analytical study of 40 subjects with acne vulgaris and 40 subjects without acne vulgaris, using a cross-sectional design. The subjects' facial skin hydration was analyzed using a CM 825 corneometer, and the severity of acne vulgaris was assessed based on Lehmann's criteria. Data were analyzed using the Spearman correlation test. Health Research Ethics Committee of the Faculty of Medicine at the University of North Sumatra has approved this study.

Results: Of the 40 subjects with acne vulgaris, women dominated (65 %) with a mean age of 19.6 ± 1.86 years old. Most subjects had moderate (50 %) degrees of acne vulgaris, followed by mild (42.5 %) and severe (7.5 %) degrees. In acne vulgaris subjects, the considered normal level of facial skin hydration was 92.5 %. The facial skin hydration found in acne vulgaris subjects was lower than non-acne vulgaris subjects with a p-value of 0.002. The degree of facial skin hydration is associated with the severity of acne vulgaris with moderate strength correlation values (p=<0.001, r= -0.453).

Conclusions: A significant correlation exists between the level of hydration of the facial skin and the severity of acne vulgaris. The lower facial skin hydration level could promote the more severe form of acne vulgaris.

References

  1. Goh CL, Abad-Casintahan F, Aw DCW, Baba R, Chan LC, Hung NT, et al. South-East Asia study alliance guidelines on the management of acne vulgaris in South-East Asian patients. J Dermatol. 2015;42(10):945–53. Available from: http://dx.doi.org/10.1111/1346-8138.12993
  2. Alanazi MS, Hammad SM, Mohamed AE. Prevalence and psychological impact of Acne vulgaris among female secondary school students in Arar city, Saudi Arabia, in 2018. Electron physician. 2018;10(8):7224–9. Available from: https://pubmed.ncbi.nlm.nih.gov/30214705
  3. Chularojanamontri L, Tuchinda P, Kulthanan K, Pongparit K. Moisturizers for acne: What are their constituents? J Clin Aesthet Dermatol. 2014;7(5):36.
  4. Ezerskaia A, Pereira SF, Urbach HP, Verhagen R, Varghese B. Quantitative and simultaneous non-invasive measurement of skin hydration and sebum levels. Biomed Opt Express. 2016;7(6):2311–20. Available from: https://pubmed.ncbi.nlm.nih.gov/27375946
  5. Lynde C. Moisturizers for the treatment of inflammatory skin conditions. J drugs dermatology JDD. 2008;7(11):1038–43.
  6. Thiboutot D, Del Rosso JQ. Acne vulgaris and the epidermal barrier: is acne vulgaris associated with inherent epidermal abnormalities that cause impairment of barrier functions? Do any topical acne therapies alter the structural and/or functional integrity of the epidermal barrier? J Clin Aesthet Dermatol. 2013;6(2):18.
  7. Yamamoto A, Takenouchi K, Ito M. Impaired water barrier function in acne vulgaris. Arch Dermatol Res. 1995;287(2):214–8. Available from: http://dx.doi.org/10.1007/bf01262335
  8. Sultana T. Evaluation of Severity in Patients of Acne Vulgaris by Global Acne Grading System in Bangladesh. Clin Pathol Res J. 2017;1(1). Available from: http://dx.doi.org/10.23880/cprj-16000105
  9. Jusuf NK, Putra IB, Sari L. Differences of microbiomes found in non-inflammatory and inflammatory lesions of acne vulgaris. Clin Cosmet Investig Dermatol. 2020;13:773.
  10. Puspita F, Simanungkalit R, Yosi A. Correlation between Serum 25-Hydroxyvitamin D Level with Acne Vulgaris Severity. Int J Sci Res Publ. 2020;10(1):p9750. Available from: http://dx.doi.org/10.29322/ijsrp.10.01.2020.p9750
  11. Rahmayani T, Putra IB, Jusuf NK. The Effect of Oral Probiotic on the Interleukin-10 Serum Levels of Acne Vulgaris. Open access Maced J Med Sci. 2019;7(19):3249–52. Available from: https://pubmed.ncbi.nlm.nih.gov/31949525
  12. Zeichner JA, Baldwin HE, Cook-Bolden FE, Eichenfield LF, Friedlander SF, Rodriguez DA. Emerging issues in adult female acne. J Clin Aesthet Dermatol. 2017;10(1):37.
  13. Khunger N, Kumar C. A clinico-epidemiological study of adult acne: Is it different from adolescent acne? Indian J Dermatology, Venereol Leprol. 2012;78(3):335. Available from: http://dx.doi.org/10.4103/0378-6323.95450
  14. Abo El-Fetoh NM, Alenezi NG, Alshamari NG, Alenezi OG. Epidemiology of acne vulgaris in adolescent male students in Arar, Kingdom of Saudi Arabia. J Egypt Public Health Assoc. 2016;91(3):144–9. Available from: http://dx.doi.org/10.1097/01.epx.0000492401.39250.62
  15. Dewi NK, Putra IB, Jusuf NK. Passion fruit purple variant ( Passiflora edulis Sims var. edulis ) seeds extract 10% cream in acne vulgaris treatment: an open?label pilot study. Int J Dermatol. 2020;59(12):1506–12. Available from: http://dx.doi.org/10.1111/ijd.15178
  16. Yahya H. Acne vulgaris in Nigerian adolescents - prevalence, severity, beliefs, perceptions, and practices. Int J Dermatol. 2009;48(5):498–505. Available from: http://dx.doi.org/10.1111/j.1365-4632.2009.03922.x
  17. White GM. Recent findings in the epidemiologic evidence, classification, and subtypes of acne vulgaris. J Am Acad Dermatol. 1998;39(2):S34–7. Available from: http://dx.doi.org/10.1016/s0190-9622(98)70442-6
  18. Sutaria AH, Masood S, Schlessinger J. Acne Vulgaris. StatPearls. 2021; Available from: https://www.ncbi.nlm.nih.gov/books/NBK459173/
  19. Dawson AL, Dellavalle RP. Acne vulgaris. BMJ. 2013;346(may08 1):f2634–f2634. Available from: http://dx.doi.org/10.1136/bmj.f2634
  20. Hidayati NZ, Riyanto P. Hubungan Tingkat Stres dengan Derajat Keparahan Acne Vulgaris (Studi pada Mahasiswa Fakultas Kedokteran Universitas Diponegoro Angkatan 2012-2015). DIPONEGORO Med J (JURNAL Kedokt DIPONEGORO). 2017;6(2):964–74.
  21. Regina Sutrisno A, Karmila Jusuf N, Budi Putra I. Correlation between Stress Scale and Severity of Acne Vulgaris. Bali Med J. 2020;9(1):376. Available from: http://dx.doi.org/10.15562/bmj.v9i1.1749
  22. Yutrishia L, Simanungkalit R, Jusuf N. Perbandingan Nilai pH Permukaan Kulit Wajah pada Kelompok Akne Vulgaris dan Kontrol. Universitas Sumatera Utara; 2016.
  23. Zhang J, Shen Y, Wang T, Zhou C, Wang X, Ding X, et al. Prevalence of Acne Vulgaris in Chinese Adolescents and Adults: A Community-based Study of 17,345 Subjects in Six Cities. Acta Derm Venereol. 2012;92(1):40–4. Available from: http://dx.doi.org/10.2340/00015555-1164
  24. El-Hamd MA, Nada EE-DA, Moustafa MA-K, Mahboob-Allah RA. Prevalence of acne vulgaris and its impact of the quality of life among secondary school-aged adolescents in Sohag Province, Upper Egypt. J Cosmet Dermatol. 2017;16(3):370–3. Available from: http://dx.doi.org/10.1111/jocd.12328
  25. A. Farage Miranda. Gender Differences in Skin Aging and the Changing Profile of the Sex Hormones with Age. J Steroids Horm Sci. 2012;03(02). Available from: http://dx.doi.org/10.4172/2157-7536.1000109
  26. See J-A, Goh CL, Hayashi N, Suh DH, Casintahan FA. Optimizing the use of topical retinoids in Asian acne patients. J Dermatol. 2018/04/03. 2018;45(5):522–8. Available from: https://pubmed.ncbi.nlm.nih.gov/29611225
  27. Kmie? ML, Pajor A, Broniarczyk-Dy?a G. Evaluation of biophysical skin parameters and assessment of hair growth in patients with acne treated with isotretinoin. Postep dermatologii i Alergol. 2013/12/18. 2013;30(6):343–9. Available from: https://pubmed.ncbi.nlm.nih.gov/24493996
  28. Inui S, Aoshima H, Nishiyama A, Itami S. Improvement of acne vulgaris by topical fullerene application: unique impact on skin care. Nanomedicine Nanotechnology, Biol Med. 2011;7(2):238–41. Available from: http://dx.doi.org/10.1016/j.nano.2010.09.005
  29. Kantikosum K, Chongpison Y, Chottawornsak N, Asawanonda P. The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study. Clin Cosmet Investig Dermatol. 2019;12:151–61. Available from: https://pubmed.ncbi.nlm.nih.gov/30858720
  30. Constantin M-M, Poenaru E, Poenaru C, Constantin T. Skin hydration assessment through modern non-invasive bioengineering technologies. Maedica (Buchar). 2014;9(1):33.
  31. Waller I, Suter B, Hettwer S, Obermayer B, Banziger S. In-Vitro Corneometry and Tewametry - Setting up skin substitute models to evaluate cosmetic moisturising materials. H&PC Today. 2015;10(4):43–50.
  32. Shen X, Guo M, Yu H, Liu D, Lu Z, Lu Y. Propionibacterium acnes related anti-inflammation and skin hydration activities of madecassoside, a pentacyclic triterpene saponin from Centella asiatica. Biosci Biotechnol Biochem. 2019;83(3):561–8. Available from: http://dx.doi.org/10.1080/09168451.2018.1547627
  33. Prescott SL, Larcombe D-L, Logan AC, West C, Burks W, Caraballo L, et al. The skin microbiome: impact of modern environments on skin ecology, barrier integrity, and systemic immune programming. World Allergy Organ J. 2017;10(1):29. Available from: https://pubmed.ncbi.nlm.nih.gov/28855974
  34. Jordan L, Baldwin HE. Stratum Corneum Abnormalities and Disease-Affected Skin: Strategies for Successful Outcomes in Inflammatory Acne. J drugs dermatology JDD. 2016;15(10):1170–3.
  35. Zhou M, Xie H, Cheng L, Li J. Clinical characteristics and epidermal barrier function of papulopustular rosacea: A comparison study with acne vulgaris. Pakistan J Med Sci. 2016;32(6):1344–8. Available from: https://pubmed.ncbi.nlm.nih.gov/28083023
  36. Mukherjee S, Mitra R, Maitra A, Gupta S, Kumaran S, Chakrabortty A, et al. Sebum and Hydration Levels in Specific Regions of Human Face Significantly Predict the Nature and Diversity of Facial Skin Microbiome. Sci Rep. 2016;6:36062. Available from: https://pubmed.ncbi.nlm.nih.gov/27786295
  37. Lynde CW, Andriessen A, Barankin B, De Gannes G, Gulliver W, Haber R, et al. Moisturizers and ceramide-containing moisturizers may offer concomitant therapy with benefits. J Clin Aesthet Dermatol. 2014;7(3):18.
  38. Turan N, Kapicioglu Y, Sarac G. The Effect of Skin Sebum, pH, and Moisture on Demodex Infestation in Acne Vulgaris and Rosacea Patients. Turkish J Parasitol. 2017;41(3):143–7. Available from: http://dx.doi.org/10.5152/tpd.2017.5068
  39. Akta? Karabay E, Aksu Çerman A. Demodex folliculorum infestations in common facial dermatoses: acne vulgaris, rosacea, seborrheic dermatitis. An Bras Dermatol. 2020/02/12. 2020;95(2):187–93. Available from: https://pubmed.ncbi.nlm.nih.gov/32113677
  40. Isoda K, Seki T, Inoue Y, Umeda K, Nishizaka T, Tanabe H, et al. Efficacy of the combined use of a facial cleanser and moisturizers for the care of mild acne patients with sensitive skin. J Dermatol. 2014;42(2):181–8. Available from: http://dx.doi.org/10.1111/1346-8138.12720

How to Cite

Yolanda, M. O., Jusuf, N. K., & Putra, I. B. (2021). Lower facial skin hydration level increases acne vulgaris severity level. Bali Medical Journal, 10(3), 1081–1084. https://doi.org/10.15562/bmj.v10i3.2195

HTML
4

Total
18

Share

Search Panel

Maya Oktari Yolanda
Google Scholar
Pubmed
BMJ Journal


Nelva Karmila Jusuf
Google Scholar
Pubmed
BMJ Journal


Imam Budi Putra
Google Scholar
Pubmed
BMJ Journal