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Relationship between IL-6, IL-1β, and vitamin D on frailty status in elderly women

  • Dwi Ngestiningsih ,
  • Jessa Kris Dayanti ,
  • Lusiana Batubara ,


Background: The aging process is associated with an increase in proinflammatory markers' serum levels, indicating that a chronic inflammatory process is correlated with an increase in disability, mortality, and frailty. Pro-inflammatory cytokines that increase with the incidence of frailty syndrome are IL-6, IL-1β and TNF-α. 25-hydroxyvitamin D (25 (OH) D) deficiency is also a potential risk factor for frailty, especially in the elderly. Vitamin D deficiency is associated with a risk of falling, which can speed up the frailty process. The aim of the study is to determine the relationship between IL-6, IL-1β and Vitamin D on frailty status in elderly women in elderly integrated health services (posyandu lansia), Semarang City.

Methods: This study used a cross sectional design with a consecutive sampling method of 27 subjects. Subjects measured vital signs, weight and height measurements. The study subjects were then taken venous blood to measure the levels of IL-6, IL-1β and vitamin D in blood serum and assessed their frailty status. Data analysis using SPSS 25 with Spearman correlation test.

Results: There were 27 elderly women who followed this study with an average age of 67.93 years. There are 16 people with pre-frail status and 3 people with frail status. There is a significant relationship between vitamin D levels in serum and frailty status (p = 0.008; r = 0.497). Variables IL-6 (p=0.328) and IL-1β (p=0.095) had no significant relationship with frailty status.

Conclusion: Most of the elderly women have a pre-frailty status, namely as much as 59.3%. Vitamin D levels in the body have a significant and unidirectional relationship with frailty status in elderly women.


  1. Topinková E. Aging, disability and frailty. Ann Nutr Metab. 2008;52:6–11.
  2. Morley JE, Baumgartner RN. Cytokine-Related Aging Process. The Journals of Gerontology: Series A. 2004; 59(9):924–9.
  3. Viña J, Tarazona-Santabalbina FJ, Pérez-Ros P, Martínez-Arnau FM, Borras C, Olaso-Gonzalez G et al. Biology of frailty: Modulation of aging genes and its importance to prevent age-associated loss of function. Mol Asp Med. 2016; 50: 88–108.
  4. Bian AL, Hu HY, Rong YD, Wang J, Wang JX, Zhou XZ. A study on relationship between elderly sarcopenia and inflammatory factors IL-6 and TNF-α. Eur J Med Res. 2017;22(1):25. doi: 10.1186/s40001-017-0266-9.
  5. Wilson D, Jackson T, Sapey E, Lord JM. Frailty and sarcopenia: The potential role of an aged immune system. Ageing Res Rev. 2017;36:1-10. doi: 10.1016/j.arr.2017.01.006.
  6. Allen SC. Systemic Inflammation in the Genesis of Frailty and Sarcopenia: An Overview of the Preventative and Therapeutic Role of Exercise and the Potential for Drug Treatments. Geriatrics (Basel). 2017;2(1):6. doi: 10.3390/geriatrics2010006.
  7. Fan J, Kou X, Yang Y, Chen N. MicroRNA-Regulated Proinflammatory Cytokines in Sarcopenia. Mediators Inflamm. 2016;2016:1438686. doi: 10.1155/2016/1438686.
  8. Zhou J, Huang P, Liu P, Hao Q, Chen S, Dong B, Wang J. Association of vitamin D deficiency and frailty: A systematic review and meta-analysis. Maturitas. 2016;94:70-76. doi: 10.1016/j.maturitas.2016.09.003.
  9. Kennel KA, Drake MT, Hurley DL. Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc. 2010;85(8):752-7; quiz 757-8. doi: 10.4065/mcp.2010.0138.
  10. Rockwood K, Mitnitski A. Unconventional Views of Frailty Review Article Frailty in Relation to the Accumulation of Deficits. Journal of Gerontology: Medical Sciences. 2007. 62(7):722-727.
  11. Xue QL. The frailty syndrome: definition and natural history. Clin Geriatr Med. 2011;27(1):1-15. doi: 10.1016/j.cger.2010.08.009.
  12. Ensrud KE, Ewing SK, Cawthon PM, Fink HA, Taylor BC, Cauley JA, Dam TT, Marshall LM, Orwoll ES, Cummings SR; Osteoporotic Fractures in Men Research Group. A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men. J Am Geriatr Soc. 2009;57(3):492-8. doi: 10.1111/j.1532-5415.2009.02137.x.
  13. Ministry of Health of the Republic of Indonesia. Situation of the Elderly in Indonesia in 2017 Indonesia Figure of Age Structure of the Indonesian Population in 2017. 2017.
  14. Marty E, Liu Y, Samuel A, Or O, Lane J. A review of sarcopenia: Enhancing awareness of an increasingly prevalent disease. Bone. 2017;105:276-286. doi: 10.1016/j.bone.2017.09.008.
  15. van den Beld AW, Kaufman JM, Zillikens MC, Lamberts SWJ, Egan JM, van der Lely AJ. The physiology of endocrine systems with ageing. Lancet Diabetes Endocrinol. 2018 Aug;6(8):647-658. doi: 10.1016/S2213-8587(18)30026-3.
  16. Ng A, Tam WW, Zhang MW, et al. IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s disease: Systematic Review and Meta-Analysis. Sci Rep. 2018;8:12050. doi:
  17. Nguyen L, Dewhirst FE, Hauschka PV, Stashenko P. Interleukin-1 beta stimulates bone resorption and inhibits bone formation in vivo. Lymphokine Cytokine Res. 1991;10(1-2):15-21.
  18. Lopez-Castejon G, Brough D. Understanding the mechanism of IL-1β secretion. Cytokine Growth Factor Rev. 2011;22(4):189-95. doi: 10.1016/j.cytogfr.2011.10.001.
  19. Žmitek K, Hribar M, Hristov H, Pravst I. Efficiency of Vitamin D Supplementation in Healthy Adults is Associated with Body Mass Index and Baseline Serum 25-Hydroxyvitamin D Level. Nutrients. 2020;12(5):1268. doi: 10.3390/nu12051268.
  20. Halfon M, Phan O, Teta D. Vitamin D: a review on its effects on muscle strength, the risk of fall, and frailty. Biomed Res Int. 2015;2015:953241. doi: 10.1155/2015/953241.

How to Cite

Ngestiningsih, D., Dayanti, J. K., & Batubara, L. (2021). Relationship between IL-6, IL-1β, and vitamin D on frailty status in elderly women. Bali Medical Journal, 10(1), 336–339.




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Dwi Ngestiningsih
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Jessa Kris Dayanti
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Lusiana Batubara
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