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Antihypertensive and Antioxidant Potential of Purple Sweet Potato Tuber Dry Extract in Hypertensive Rats


Background: Purple sweet potato tuber extract in liquid form has been shown to lower blood pressure of hypertensive rats and hypertensive patients. Liquid dosage form increasingly unstable when stored for long periods, thus it is necessary to find a more stable dosage form. The objective of this research was to prove that dry extract of purple sweet potato tuber has the same effects with liquid extract in hypertensive rats. The is a randomized pre-test and post-test control group design study. Thirty hypertensive model rats were divided into 5 groups (6 animals for each group). Group 1 was treated as a control group. Group 2 to group 5 were treated as treatment groups. Treatment groups were given liquid extract at a dose of 3 ml, dry extract with the dose of 200 mg, dry extract that stored in a certain time with a dose of 200 mg and given a mixture of dry extract with a carrier substance (capsule formula) with a dose of 200 mg, respectively, for 4 weeks. Variables observed were blood pressure, SOD and MDA level of the blood. The results showed that the group given the purple sweet potato tuber extract lowers blood pressure were significantly in liquid extract or dry extract (p <0.01). The group that was treated with capsule formula showed more decrease in blood pressure than dry extract group (p <0.01). The similar results happened on MDA and SOD level in blood. Thus, it can be concluded that dried extract of purple sweet potato tubers has the same effectiveness with liquid extract, both as an antihypertensive and also antioxidant. Capsules formula is more effective than liquid extract and dry extract.



  1. Knekt P, Kumpulainen J, Jarvinen R, Rissanen H, Heliovaara M, Reunanen A, Hakulinen T, Aromaa A. 2002. Flavonoid intake and risk of chronic diseases. Am J Clin Nutr, Vol 76, No 53: 560-568.
  2. Engler MB, Engler MM, Chen CY, et al. 2004. Flavonoid-Rich Dark Chocolate Improves Endothelial Function and Increases Plasma Epicatechin Concentrations in Healthy Adults. Journal of The American College of Nutrition, 23, No. 3, 197-204.
  3. Erdman J W, Balentine D, Arab L, Beecher G, Dwyer J T, Folts J, et al. 2007. Flavonoids and Heart Health. J. Ntr 137, 718-723. Release. Circulation; 103: 2792-2798.
  4. Han, X., Shen, T., and Lou, H. 2007. Dietary polyphenol and Their Biological significance. Int.J.Mol.Sci, 8: 950-988.
  5. Morris, Brian J. 2007. Climate not cultivars in the NO-ing of red wines. Journal of Hypertension, 25 (3) 501-503.
  6. Suprapta, D.N., dkk 2004. Kajian Aspek Pembibitan, Budidaya dan Pemanfaatan umbi-umbian sebagai sumber pangan alternatif. Laporan Hasil Penelitian. Kerjasama BAPEDA Propinsi Bali dengan Fakultas Pertanian UNUD.
  7. Padda, M.S. 2006. “Phenolic Composition and Antioxidant Activity of sweetpotatoes (Ipomoea batatas, L)â€. (A Dissertation). Submitted to the Graduate Faculty of the louisiana State University and Agricultural and Mechanical College in partial fulfillment of the requirement for the degree of Doctor of Philosphy in The Department of Horticulture.
  8. Lachman J, Hamouz K, Sulc M, Orsak M, Pivec V, Hejtmankova A, Dvorak P, Cepl J. 2009. Cultivar differences of total anthocyanins and anthocyanidins in red and purple-fleshed potatoes and their relation to antioxidant activity. Food Chemistry, 144:836-43.
  9. Jiao, Y., Jiang, Y., Zhai, W., and Yang, Z. 2012. Studies on antioxidant capacity of anthocyanin extract from purple sweet potato (Ipomoea batatas L). African Journal of Biotechnology, 11(27):7046-54.
  10. Kano M, Takayanagi T., Harada, K., Makino, K., and Ishikawa, F. 2005. Antioxidative Activity of Anthocyanins from Purple Sweet Potato, Ipomoea batatas Cultivar Ayamurasaki. Biosci Biotechnol. Biochem,69(5):979-88.
  11. Jawi I M, Suprapta D N, Dwi S U, Wiwiek I. 2008. Ubi Jalar Ungu Menurunkan Kadar MDA dalam Darah dan Hati Mencit setelah Aktivitas Fisik Maksimal. Jurnal Veteriner Jurnal Kedokteran Hewan Indonesia. 9(2):65-72.
  12. Garcia-Alonso M, Minihane A.M, Rimbach, G, Rivas-Gonzalo J.C, de Pascual-Teresa, S. 2009. Red wine anthocyanins are rapidly absorbed in humans and affect monocyte chemoattractant protein 1 levels and antioxidant capacity of plasma. J Nutr Biochem, 20(7):521-9.
  13. Jawi I M, Sutirta-Yasa I W P, Suprapta D N, Mahendra A N. 2012. Antihypertensive effect and eNOS expressions in nacl-induced hypertensive rats treated with purple sweet potato. Universal Journal of Medicine and Dentistry, 1(9):102-107.
  14. Jawi I M, Artini I G A, Mahendra A N and Suprapta D N. 2014a. Purple Sweet Potato Aqueous Extract Lowers Blood Pressure andPrevents Oxidative Stress in Hypertensive Elderly Patients atNyuhkuning Village, Mas, Ubud, Bali. Journal of Biology, Agriculture and Healthcare, Vol.4, No.21.
  15. Jawi I M., Sutirta Yasa I W P. 2014b. Perbandingan Potensi Antihipertensi dan Antioksidan Antara Ekstrak Umbi Ubijalar Ungu dengan Captopril Serta Kombinasinya pada Penderita Hipertensi. (Penelitian tahap 1, 2014b, Belum dipublikasi).
  16. Zhao Z and Li T. 2015. Extraction and Purification of Pigment from Purple Sweet Potato Wine Vinasse. Advance Journal of Food Science and Technology 7(4): 298-301, 2015

How to Cite

Jawi, I. M., Yasa, I. W. P. S., & Mahendra, A. N. (2016). Antihypertensive and Antioxidant Potential of Purple Sweet Potato Tuber Dry Extract in Hypertensive Rats. Bali Medical Journal, 5(2), 252–255.




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